NCT05491031Recruiting
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
Evaluation of MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
The transition from relapsing-remitting multiple sclerosis to secondarily progressive multiple sclerosis (SPMS) is difficult to identify. Typically, SPMS is diagnosed retrospectively, with a significant delay, on the basis of a clinical history of progressive worsening, independent of relapses. Thus, SPMS is often associated with a considerable period of diagnostic uncertainty. The use of ultra-high field imaging can shed light on the mechanisms of disability progression thanks to its better spatial resolution and advanced imaging techniques. The new morphological imaging techniques make it possible to visualize chronic inflammatory lesions and to evaluate their evolution. It also allows for the precise measurement of brain atrophy, a reference in the evaluation of neurodegeneration. Metabolic imaging via proton spectroscopy allows the analysis of several promising cerebral metabolites that can provide information on cellular energy metabolism, mitochondrial function, or oxidative stress, and can help identify tissues at risk of neurodegeneration. Sodium imaging can provide information on axonal energy metabolism before the occurrence of stable and irreversible axonal damage. This technique is promising as an early marker of neurodegeneration.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 5 Apr 2022
- Start date
- 25 Apr 2023
- Primary completion date
- 1 May 2030
- Lead sponsor
- Poitiers University Hospital
- Diseases
- Multiple sclerosis
- NCT number
- NCT05491031
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 25 Apr 2023 to the primary completion date, 1 May 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A course of corticosteroids (oral or intravenous) for less than one month,
Other illness
- Other progressive neurological disease,
- Isolated radiologic syndrome (RIS),
- Severe psychiatric pathology not in balance,
- Patient with a contraindication to MRI: pregnancy, metallic ocular foreign body (accidental splinters or others), pacemaker, implantable defibrillator, neurostimulator not compatible with MRI 7.0 T, cochlear implants and in general any electronic medical equipment implanted in an irremovable way: metallic cardiac valve, vascular clips (formerly implanted on cranial aneurysm), metallic prosthesis...),
Age
- Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
Other
- Change in dosage, discontinuation or initiation of a psychotropic treatment within the last month,
- Change in background MS treatment for less than 3 months,
- Illiterate and non-French speaking patient: patient who is partially or completely unable to read and write French.
- Patient benefiting from reinforced protection, i.e. minor, subject deprived of liberty by a judicial or administrative decision, subject staying in a health or social establishment, adult under legal protection and finally patient in emergency situation,
Who the study is looking for
- Age ≥ 18 years,
- Duration of disease ≤ 25 years,
- Irreversible disability ≤ 7 (permanent wheelchair use) on the EDSS scale
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| PoitiersUH Coordinator of this site? Confirm its status | Poitiers | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.