NCT05493904Active, not recruiting
PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX)
Impact of Optical Coherence Tomography-guided Versus Angiography-guided Stent Optimization on Post-Interventional Fractional Flow Reserve in Patients With Complex Coronary Artery Lesions
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
The aim of the study is to compare post-interventional fractional flow reserve (FFR) value between optical coherence tomography(OCT)-guided and angiography-guided strategy for treatment of complex coronary lesion.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 320 (actual)
- First submitted
- 7 Aug 2022
- Start date
- 1 Nov 2022
- Primary completion date
- 5 Dec 2024
- Lead sponsor
- Chonnam National University Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT05493904
What you commit to
- Study type: Interventional
- Participants enrolled: 320
- From 1 Nov 2022 to the primary completion date, 5 Dec 2024
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known true anaphylaxis to contrast medium (not allergic reaction but anaphylactic shock)
- Renal insufficiency such that an additional contrast medium would be harmful for patient
- Recent ST-segment elevation myocardial infarction (STEMI)
- Non-cardiac co-morbid conditions are present with life expectancy \<2 year or that may result in protocol non-compliance (per site investigator's medical judgment)
Other
- Target lesions not amenable for PCI by operators' decision
- Cardiogenic shock (Killip class IV) at presentation
- Less than TIMI 3 flow of target vessel after index procedure
- Intolerance to Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Heparin, Everolimus, Zotarolimus, Biolimus, or Sirolimus
- Inability to receive adenosine or nicorandil injection
- Pregnancy or breast feeding
- Unwillingness or inability to comply with the procedures described in this protocol
Who the study is looking for
- Patients \>18 years old
- Patients with stable or unstable angina and complex coronary lesions\*
- Patients who were indicated revascularization
- Diameter stenosis \>90% by angiography
- Diameter stenosis with 50\~90% with pre-interventional FFR ≤0.80
- Patients who underwent implantation of 2nd generation drug-eluting stent
- Definitions of complex coronary lesions
- True bifurcation lesion (Medina 1,1,1/1,0,1/0,1,1) with side branch ≥2.5mm size
- Chronic total occlusion (≥3 months) as target lesion
- PCI for unprotected left main (LM) disease (LM os, body, distal LM bifurcation including non-true bifurcation)
- Long coronary lesions (implanted stent ≥38 mm in length)
- Multi-vessel PCI (≥2 major epicardial coronary arteries treated at one PCI session)
- Multiple stents needed (≥3 more stent per patient)
- In-stent restenosis lesion as target lesion
- Severely calcified lesion (encircling calcium in angiography)
- Left anterior descending (LAD), left circumflex artery (LCX), and right coronary artery (RCA) ostial lesion
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chonnam National University Hospital Coordinator of this site? Confirm its status | Gwangju | South Korea | Unknown status |
| Chung-Ang University Gwangmyeong Hospital Coordinator of this site? Confirm its status | Gwangmyeong | South Korea | Unknown status |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.