NCT05507905Active, not recruiting
Effects of Dance and Music Appreciation on Brain Health and Fitness in People at Risk for Alzheimer's Disease
Establishing the Optimal Frequency of Dance Movement for Neurocognitive and Physical Outcomes in People at Risk of Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 17 Mar 2026
Brief summary (registry, in English)
The purpose of this research study is to study the effects of dance movement and music on memory and cardiorespiratory fitness in older adults who are concerned about memory loss. The study aims to determine the optimal number of movement or music appreciation classes a week to support brain health and fitness. Participants will be people 62 years or older who are concerned about their memory, but do not yet have a diagnosis of cognitive impairment. If a participant is deemed qualified to participate, he/she will be placed into one of four groups and will attend 1, 2, or 3 group or music appreciation classes per week for 24 weeks (6 months). In addition to attending the group classes, participants will be asked to complete at least four study visits at Wake Forest Baptist Medical Center to complete various clinical assessments, including a brain MRI.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 165 (actual)
- First submitted
- 17 Aug 2022
- Start date
- 24 Apr 2023
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Wake Forest University Health Sciences
- Diseases
- Alzheimer disease
- NCT number
- NCT05507905
What you commit to
- Study type: Interventional
- Participants enrolled: 165
- From 24 Apr 2023 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking medication during the intervention times that could negatively influence safety
- Enrolled in another interventional research study ≤3 months prior to beginning this study.
- Hip fracture, hip or knee replacement, or spinal surgery in past 6 months.
- Self-reports regularly drinking \> 14 alcoholic beverages a week or current illicit drug use.
Other illness
- Current diagnosis of a major neurological disorder (Alzheimer's disease, Lewy body dementia, Frontotemporal dementia, Parkinson's disease, amyotrophic lateral sclerosis, etc.)
- Currently symptomatic or cortical stroke or stroke deemed exclusionary by the study physician. Reported or observed evidence of strokes on MRI will be reviewed on a case-by-case basis by the study physician to assess factors such as location, size, time since stroke, and residual symptoms.
- Current cancer treatment or other major medical problems that might independently affect cognition or movement or interfere with ability to attend intervention or study visits.
Lab values
- Health contraindications for completing a graded exercise test and movement intervention, including uncontrolled hypertension (BP\>200/110 mmHg), hypertriglyceridemia (TG\>400 mg/dl), uncontrolled diabetes (HbA1c \> 7.5), clinical evidence of anemia.
Other
- Unable or unwilling to attend intervention classes 1-3x/week
- Unwilling or unable to provide consent for study participation.
- Chronic vertigo.
- Unable or unwilling to understand study procedures and comply with them for the duration of the study.
Who the study is looking for
- Cognitive Change Index score ≥16
- Montreal Cognitive Assessment (MoCA) score ≥21
- Cognitively normal
- Low-active for past 6 months (\<30 min, 3 days/week of exercise, including walking for exercise)
- MRI compatible
- Willing and able to complete exercise testing.
- Has reliable transportation or is able to use transportation provided by the study.
- English speaking (needed for group class participation)
Age in the registry: 62 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wake Forest School of Medicine Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.