NCT05511467Completed
Learning in Stroke
Neural Circuitries of Motor Learning as a Target to Modulate Sensorimotor Recovery After Stroke
Source: ClinicalTrials.gov · Last updated 20 Oct 2025
Brief summary (registry, in English)
After a stroke, plasticity occurs in the brain from microscopic to network level with positive but also negative consequences for functional recovery. Why post-stroke plasticity takes a beneficial or a maladaptive direction is still incompletely understood. Because the biological mechanisms underlying sensorimotor learning parallel those observed during recovery, learning mechanisms could be potential modifiers of post-stroke neuroplasticity and have a discrete mal-/adaptive impact on the recovery of sensorimotor function. This project seeks to further the understanding of the link between brain circuits that control the integration of new information during procedural learning in the injured brain and those circuits that are involved in adaptive plastic changes during recovery of sensorimotor function post-stroke. The project's methodological approach will allow the characterization of procedural learning-related neural network dynamics based on functional magnetic resonance imaging (MRI) in human volunteers with and without neurologically impairment post-stroke. Through multivariate integration of behavioral and biological descriptors of sensorimotor recovery, the project will investigate the association between motor learning-related network dynamics and descriptors of recovery.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 40 (actual)
- First submitted
- 9 Aug 2022
- Start date
- 1 Sept 2022
- Primary completion date
- 31 Mar 2024
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Stroke
- NCT number
- NCT05511467
What you commit to
- Study type: Observational
- Participants enrolled: 40
- From 1 Sept 2022 to the primary completion date, 31 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- other concomitant neurological disorders affecting upper extremity motor function
- intake of tricyclic anti-depressants or neuroleptic medication.
Other illness
- substance use disorder
- psychotic disorders
- Stroke-group specific exclusion criteria:
- subarachnoid hemorrhage
- documented history of dementia before or after stroke
- uncontrolled hypertension despite treatment
Other
- For all participants:
- Presence of any MRI risk factors
- Primary intracerebral hematoma
- bi-hemispheric or cerebellar strokes
- severe aphasia, particularly of receptive nature (NIHSS Language subsection ≥2), affecting their ability to understand the purpose of the study and give informed consent
Who the study is looking for
- For all participants:
- adult volunteers (age ≥18 years)
- right-hand dominance as defined by the Edinburgh Handedness Inventory
- Stroke-specific inclusion criteria:
- ischemic or hemorrhagic lesion
- subcortical or cortical tissue involvement
- chronic phase (\>6 months) after their index lesion
- voluntary whole-hand grip force (MRC, Medical Research Council scale for muscle force ≥2)
- repeated release (standardized as a reduction of 50% of maximum voluntary contraction measured with a dynamometer)
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.