NCT05521776Recruiting
Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)
Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity : a Multicenter Randomized Trial
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to determine whether first-trimester screening for preeclampsia based on the FMF algorithm (a combination of maternal clinical, sonographic and biochemical parameters), improves maternal or perinatal health.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 14500 (estimated)
- First submitted
- 7 Jul 2022
- Start date
- 6 Mar 2023
- Primary completion date
- Aug 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- NCT number
- NCT05521776
What you commit to
- Study type: Interventional
- Planned participants: 14500
- From 6 Mar 2023 to the primary completion date, Aug 2026
- 22 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of PE in a previous pregnancy
Other illness
- Contra-indication to aspirin (bleeding disorders such as von Willebrand's disease, active peptic ulceration, hypersensitivity to aspirin, active peptic ulceration, NSAID-exacerbated respiratory disease, severe liver or heart dysfunction)
Age
- Gestational age \<11 WG or \>14 WG
- Age \<18 years
Other
- Known ectopic pregnancy
- Known non-ongoing pregnancy
- Known multiple pregnancy
- Pregnancies complicated by major fetal abnormality identified at the first-trimester ultrasound if performed before randomization
- Absence of health insurance
- Women taking low-dose aspirin regularly and started before pregnancy (except ART indication)
- Poor understanding of the French language
Who the study is looking for
- Pregnancy between 11 and 14 WG
- Age ≥18 years
- Affiliated to or beneficiary of a health insurance system (including AME)
- Signed informed consent
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (22)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Angers Coordinator of this site? Confirm its status | Angers | France | Recruiting |
| CHU de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Recruiting |
| Hôpital Femme Mère Enfant Coordinator of this site? Confirm its status | Bron | France | Recruiting |
| Hopital Antoine Beclere Coordinator of this site? Confirm its status | Clamart | France | Recruiting |
| CHU Estaing Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Recruiting |
| Hôpital Intercommunal Créteil Coordinator of this site? Confirm its status | Créteil | France | Recruiting |
| Chu Dijon Bourgogne Coordinator of this site? Confirm its status | Dijon | France | Recruiting |
| CHU Lille Coordinator of this site? Confirm its status | Lille | France | Recruiting |
| Hôpital de la conception et de la Timone Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
| Hôpital Nord Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
| CHRU de Nancy Coordinator of this site? Confirm its status | Nancy | France | Recruiting |
| Hôpital Femme - Maternité Coordinator of this site? Confirm its status | Nantes | France | Recruiting |
| Hôpital Cochin - Site Port-Royal Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| Hôpital Armand-Trousseau Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| Hopital Saint Joseph Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| CHI de Poissy Coordinator of this site? Confirm its status | Poissy | France | Recruiting |
| Hôpital Sud Rennes Coordinator of this site? Confirm its status | Rennes | France | Recruiting |
| CHU Charles Nicolle Coordinator of this site? Confirm its status | Rouen | France | Recruiting |
| Hôpital de Hautepierre Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
| CHU Strasbourg, CMCO Schiltigheim Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
| Hopital Paule de Viguier Coordinator of this site? Confirm its status | Toulouse | France | Recruiting |
| Hopital Bretonneau Coordinator of this site? Confirm its status | Tours | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.