NCT05524012Active, not recruiting
Longitudinal Multimodal Response Assessment During Neoadjuvant Treatment of Rectal Cancer
Planning Adaptive Treatment by Longitudinal Response Assessment Implementing MR Imaging, Liquid Biopsy and Analysis of Microenvironment During Neoadjuvant Treatment of Rectal Cancer (PRIMO)
Source: ClinicalTrials.gov · Last updated 6 Aug 2026
Brief summary (registry, in English)
This pilot study aims to trial multimodal early response assessment to enable therapy adaptions in the context of non-operative therapy strategies of locally advanced rectal cancer (LARC) for development of a non-invasive response prediction model.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 30 Aug 2022
- Start date
- 30 Nov 2022
- Primary completion date
- 31 Jan 2026
- Lead sponsor
- Jena University Hospital
- Diseases
- Colorectal cancer
- NCT number
- NCT05524012
What you commit to
- Study type: Observational
- Planned participants: 40
- From 30 Nov 2022 to the primary completion date, 31 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- locally advanced rectal cancer (LARC): UICC Stage II/III
- no severe cardiac or lung disease
- no severe hepatic disorders (liver enzymes \<2.5 NR) or restrictions of renal function (GFR \> 30ml/min)
- no severe cytopenia (Neutrocytes \>= 3 Gpt/l; Thrombocytes \>= 100 Gpt/l; Hemoglobin \>6mmol/l)
- no homozygotic DPD deficiency
- no other neoplasms requiring therapy
- no earlier radiotherapy of the pelvis or earlier chemotherapy
- no contraindications for MRI
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Radiotherapy and Radiation Oncology, Jena University Hospital Coordinator of this site? Confirm its status | Jena | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.