NCT05524493Recruiting
High-field MR Imaging in Migraine, Visual Snow and Epilepsy
Source: ClinicalTrials.gov · Last updated 8 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
In this project, the aim is to recruit patients with drug resistant epilepsy and those suffering from migraine. Interestingly, patients suffering from epilepsy are also more often reporting to suffer from migraine. The pathobiology is understudied, but it is believed that both etiologies results from brain networks changes. A clinical certified 7T Terra Siemens scanner will be employed to assess in all participants (including healthy controls) how the microstructure differs in disease specific areas. Patients will further be clinically assessed as well as undergo questionnaires. Migraine is also a common comorbidity to visual snow syndrom and has been shown to impact similar brain regions. However, the pathophysiology is still understudied and a better understanding of the two diseases is needed.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 18 Aug 2022
- Start date
- 1 Mar 2025
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- University of Zurich
- NCT number
- NCT05524493
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Mar 2025 to the primary completion date, 30 Jun 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment of migraine disease with Botox within \< 4 months before baseline and during the study period
- Known or suspected noncompliance with the protocol, drug or alcohol abuse,
- Prior participation in the clinical trial
- Metallic objects in the body (e.g., splinters, MR incompatible implants).
Other illness
- Other clinically significant comorbidities (e.g., renal insufficiency, hepatic dysfunction, cardiovascular disease, etc.),
- Patient's inability to follow trial procedures, e.g., due to language problems, mental illness, dementia, etc.,
Age
- Women with bilateral ovariectomy, with or without hysterectomy, and postmenopausal women (\>2 years of age) are not considered childbearing.
Other
- Pregnant or breastfeeding women
- Intention during the course of the trial to become pregnant
- Enrolment of the investigator, his/ her family members, employees and other dependent persons of the test personnel
- Pacemaker
- Claustrophobia
- Obesity (body mass index \> 35 kg/m2)
Who the study is looking for
- Patients:
- Patient must be able to read and sign the informed consent form
- Stable prophylactic medication for 2 months prior to MRI
- At leat one of the two criteria applies:
- Patients diagnosed with migraine (with or without aura, episodic or chronic). Diagnosis is ensured by clinical interview (at least 8 weeks prior to MRI). Also, patients complete a migraine questionnaire (HARDSHIP) (at least 8 weeks before MRI). Migraine frequency ≥ 2 migraine attacks/month.
- Patients with drug resistent epilepsy accroding to ILAE crtieria
- Patients with diagnoses of Visual snow syndrome
- Healthy participants;
- No migraine (validated by questionnaire) or epilepsy
- Participants must be able to read and sign the informed consent form
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Klinik Lengg Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
| University Hospital Zurich Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.