NCT05528718Completed
SMILE Trial - Imaging Sub-Study
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial - Sub-Study Protocol to Include Neuroimaging
Source: ClinicalTrials.gov · Last updated 27 Mar 2026
Brief summary (registry, in English)
This is a pilot sub-study of an ongoing trial comparing N2O to midazolam in MDD and will examine neuroimaging correlates of treatment response.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 11 (actual)
- First submitted
- 2 Sept 2022
- Start date
- 7 Mar 2023
- Primary completion date
- 30 Mar 2024
- Lead sponsor
- Unity Health Toronto
- Diseases
- Depression
- NCT number
- NCT05528718
What you commit to
- Study type: Observational
- Participants enrolled: 11
- From 7 Mar 2023 to the primary completion date, 30 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Contraindication for undergoing MRI scans (e.g., hip circumference \< 180 cm or metal in the body)
Who the study is looking for
- Eligible for main nitrous oxide (SMILE) study
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Michael's Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.