NCT05529706Completed
Community-based Brain Health Program to Address Dementia Risk
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
This is a validation study to evaluate the acceptability, feasibility and preliminary efficacy of the Brain Health Program, a multimodal curriculum covering dementia risk factors and evidence-based change interventions. The goal of this study is to evaluate the Brain Health Program in individuals with identified risk factors for the onset of dementia and to prepare for a large-scale efficacy trial in this population.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 86 (actual)
- First submitted
- 2 Sept 2022
- Start date
- 24 Apr 2023
- Primary completion date
- 18 Oct 2024
- Lead sponsor
- Posit Science Corporation
- Diseases
- Alzheimer disease
- NCT number
- NCT05529706
What you commit to
- Study type: Interventional
- Participants enrolled: 86
- From 24 Apr 2023 to the primary completion date, 18 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants enrolled in a concurrent clinical trial involving an investigational pharmaceutical, nutraceutical, medical device, or behavioral treatment that could affect the outcome of this study. However, participation in standard treatments (e.g., occupational therapy) or use of prescribed medications (e.g., anti-depressants) is allowable.
Other illness
- Cognitive Abilities Screening Instrument - Short (CASI-Short) scores ≤ 25 (suggestive of cognitive impairment)
- Participants with untreated psychiatric conditions, including substance abuse/dependence disorders.
- Participants presently attending classes or courses like this program that is focused on dementia risk and behavior management.
Other
- Inability to provide informed consent
Who the study is looking for
- Participants who are 65 years of age or older.
- Participants who meet criteria for one or more ADRD dementia risk factors
- Family history of Alzheimer's dementia (1st degree relative)
- Genetic marker (APOE4++)
- Subjective or objective cognitive decline (neuropsychological testing; or self-reported "yes" to the following question: "In the past two years, have you experienced a decline in your memory or thinking?"
- Poorly controlled hypertension or diabetes
- Physical inactivity \<150min/week per Surgeon General guidelines
- Social isolation, in which participant rarely or never gets social and emotional support when needed
- Participants who are fluent English or Spanish speakers, per self-report, to ensure reasonable neuropsychological results on key assessments.
- Participants have access to an internet accessible device (eg. laptop, desktop computer, tablet or smartphone)
- Participants are able to attend all 12 classes (once a week for 12 weeks) and make up missed classes, as needed
- Participants are able to travel to/from YMCA location, if they choose to be a part of the in-person group
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| YMCA of San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.