The Effectiveness and Safety of XELOX and Tislelizumab + PLD for Resectable Gastric Cancer (LidingStudy)

Prior treatment

• Received chemotherapy, radiotherapy or immunotherapy for this gastric cancer.
• Women of childbearing age who had a positive pregnancy test at baseline or who did not have a pregnancy test. Menopausal women must have menopause for at least 12 months before they can become pregnant.
• Organ transplantation requires immunosuppressive therapy.
• Severe uncontrolled repeated infections, or other serious uncontrolled concomitant diseases.
• Participating in other trials within 4 weeks before enrollment.

Other illness

• Patients with mass ascites and positive abdominal free cancer cells.
• With a history of other malignancies in the last 5 years, except for cured non-melanoma skin cancer and cervical carcinoma in situ.
• With a history of epilepsy, central nervous system disease, or mental disorder may be judged by the investigator that their clinical severity may hinder the signing of informed consent or affect the patient's oral medication compliance.
• Clinically severe (i.e. active) heart disease, such as symptomatic coronary heart disease, New York Heart Association (NYHA) grade II or more severe congestive heart failure, or severe arrhythmia requiring medical intervention, or the last 12 There was a history of myocardial infarction within months.
• Peripheral nerve disease ≥ NCI CTC AE grade 2. However, the patients only with deep tendon reflex (DTR) disappears do not need to be excluded.
• Acute or chronic active hepatitis B, hepatitis C infection, hepatitis B virus (HBV) DNA\>2000IU/ml or 10\^4 copies/ml, hepatitis C virus (HCV) RNA\>10\^3 copies/ml, hepatitis B surface antigen (HbsAg) is positive at the same time as anti-HCV antibody.
• Allergic to any research drug ingredients.

Lab values

• Moderate or severe renal damage \[creatinine clearance ≤50ml/min (calculated according to Cockroft and Gault equation), or serum creatinine\> ULN\].

Other

• Pregnant or breastfeeding women.
• Men and women who are sexually active (possible to have children) are unwilling to use contraception during the study period.
• Patients deficiency of dihydropyrimidine dehydrogenase (DPD).
• Not suitable to participate in this trial for any reason judged by the investigator.

• Age: 18\~75 years old.
• Karnofsky Performance Status Score ≥70.
• Histological or cytological diagnosed as gastric adenocarcinoma, HER2-, PD-1/L1+.
• Clinical stage stage III (8th edition of the AJCC Cancer Staging Manual).
• Physical condition and organ function allow for larger abdominal surgery.
• Subject baseline blood routine and biochemical indicators meet the following standards: hemoglobin ≥90g/L; absolute neutrophil count (ANC) ≥1.5×10\^9g/L; platelets counts (PLT) ≥100×10\^9/L; alanine aminotransferase (ALT), aspartate aminotransferase (AST) ≤2.5 times the upper limit of normal (ULN); serum total bilirubin \<1.5 ULN; serum creatinine \<1 ULN; serum albumin ≥30g/L.
• Heart function:
  • Left ventricular ejection fraction (LVEF) ≥50%;
  • 12-ECG indicates no myocardial ischemia;
  • No history of arrhythmia requiring drug intervention before enrollment;
• No serious concomitant diseases that make the survival time \< 5 years.
• Agree and be able to comply with the protocol during the study period.
• Provide written informed consent before entering the study.