Fact CheckerSign in

NCT05536297CompletedPhase 3

Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy

An Open-label Extension (OLE) Phase 3 Trial to Assess the Safety of Intravitreal Administration of Avacincaptad Pegol (Complement C5 Inhibitor) in Patients With Geographic Atrophy Who Previously Completed Phase 3 Study ISEE2008 (GATHER2)

Source: ClinicalTrials.gov · Last updated 18 May 2026

Brief summary (registry, in English)

The purpose of this study is to assess long-term safety of avacincaptad pegol intravitreal administration for patients with geographic atrophy (GA) who completed Study ISEE2008 (GATHER2) through the Month 23 visit on study treatment (either avacincaptad pegol or Sham).

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
278 (actual)
First submitted
7 Sept 2022
Start date
26 Sept 2022
Primary completion date
10 Apr 2025
Lead sponsor
Astellas Pharma Global Development, Inc.
NCT number
NCT05536297
EU CT number
2024-515185-13-00
EudraCT number
2022-002860-59

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 278
  • From 26 Sept 2022 to the primary completion date, 10 Apr 2025
  • 117 sites in 17 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patient who had the study drug permanently withdrawn for an AE during ISEE2008 are not eligible.

Other

  • Patient did not complete Study ISEE2008 (GATHER2) through the Month 24 visit on study treatment (either avacincaptad pegol or Sham).
  • Patient did not enroll into this OLE trial within the 90 day enrollment period.
  • Patient who is pregnant or nursing.

Who the study is looking for

  • Male or female patients aged 50 years or greater diagnosed with GA inside and/or outside of the fovea who completed Study ISEE2008 (GATHER2) through the Month 24 visit on study treatment.
  • Patient must provide new written informed consent for this OLE trial prior to participation.
  • Patient must have the ability to return for all trial visits for the duration of the 18-month trial.

Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (117)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Centro Oftalmológico Dr. Charles
Coordinator of this site? Confirm its status
Buenos AiresArgentinaUnknown status
Instituto Oftalmologico de Buenos Aires
Coordinator of this site? Confirm its status
Buenos AiresArgentinaUnknown status
Oftar Mendoza
Coordinator of this site? Confirm its status
MendozaArgentinaUnknown status
Oftalmólogos Especialistas
Coordinator of this site? Confirm its status
RosarioArgentinaUnknown status
Microcirugia Ocular
Coordinator of this site? Confirm its status
Santa FeArgentinaUnknown status
Medical University of Graz
Coordinator of this site? Confirm its status
GrazAustriaCompleted
Medical University of Vienna
Coordinator of this site? Confirm its status
ViennaAustriaCompleted
Centre for Eye Research Australia
Coordinator of this site? Confirm its status
East MelbourneAustraliaUnknown status
Sydney Retina Clinic
Coordinator of this site? Confirm its status
SydneyAustraliaUnknown status
Association Hospitaliere De Bruxelles Et De Schaerbeek Centre Hospitalier Universitaire Brugmann
Coordinator of this site? Confirm its status
BrusselsBelgiumCompleted
Centro de Ensino e Pesquisa do Instituto de Visao
Coordinator of this site? Confirm its status
Belo HorizonteBrazilUnknown status
IPEPO Instituto Da Visao
Coordinator of this site? Confirm its status
São PauloBrazilUnknown status
Universidade Federal de Sao Paulo
Coordinator of this site? Confirm its status
São PauloBrazilUnknown status
Calgary Retina Consultants
Coordinator of this site? Confirm its status
CalgaryCanadaUnknown status
St. Joseph's Health Care London
Coordinator of this site? Confirm its status
LondonCanadaUnknown status
Retina Centre of Ottawa
Coordinator of this site? Confirm its status
OttawaCanadaUnknown status
Fundacion Oftalmologica Nacional
Coordinator of this site? Confirm its status
BogotáColombiaUnknown status
Clinica de Oftalmologia Sandiego
Coordinator of this site? Confirm its status
MedellínColombiaUnknown status
Axon Clinical s.r.o.
Coordinator of this site? Confirm its status
Prague 5CzechiaCompleted
Universitaetsklinikum Bonn AöR
Coordinator of this site? Confirm its status
BonnGermanyCompleted
University Hospital Cologne AöR
Coordinator of this site? Confirm its status
CologneGermanyCompleted
University Medical Center Hamburg-Eppendorf
Coordinator of this site? Confirm its status
HamburgGermanyCompleted
Medizinische Hochschule Hannover
Coordinator of this site? Confirm its status
HanoverGermanyCompleted
Ludwig-Maximilians-Universitaet Muenchen
Coordinator of this site? Confirm its status
MunichGermanyCompleted
Augenzentrum Am St Franziskus-Hospital Muenster
Coordinator of this site? Confirm its status
MunsterGermanyCompleted
Institut Catala De Retina S.L.
Coordinator of this site? Confirm its status
BarcelonaSpainCompleted
Centro De Oftalmologia Barraquer S.A.
Coordinator of this site? Confirm its status
BarcelonaSpainCompleted
Bilboftal S.L.
Coordinator of this site? Confirm its status
BilbaoSpainCompleted
Oftalmologia Vistahermosa S.L.
Coordinator of this site? Confirm its status
BurjassotSpainCompleted
Metavision Arruzafa S.L.
Coordinator of this site? Confirm its status
CordobaSpainCompleted
Hospital Universitario Puerta de Hierro de Majadahonda
Coordinator of this site? Confirm its status
MajadahondaSpainCompleted
Valles Ophthalmology Research S.L.
Coordinator of this site? Confirm its status
Sant Cugat Del VallesSpainCompleted
Instituto Oftalmologico Gomez-Ulla S.L.
Coordinator of this site? Confirm its status
Santiago De CompostelaSpainCompleted
Hospital Universitario Rio Hortega
Coordinator of this site? Confirm its status
ValladolidSpainCompleted
Hospital Clinico Universitario Lozano Blesa
Coordinator of this site? Confirm its status
ZaragozaSpainCompleted
Centre hospitalier Universitaire de Bordeaux
Coordinator of this site? Confirm its status
BordeauxFranceCompleted
Centre Hospitalier Intercommunal Créteil
Coordinator of this site? Confirm its status
CréteilFranceCompleted
Pole Vision Val d'Ouest
Coordinator of this site? Confirm its status
ÉcullyFranceCompleted
Selarl Centre Ophtalmologique Rabelais Imagerie Laser Et Reeducation De La Basse Vision
Coordinator of this site? Confirm its status
LyonFranceCompleted
Hospices Civils De Lyon
Coordinator of this site? Confirm its status
Lyon Cedex 04FranceCompleted
Centre Monticelli Paradis d'Ophtalmologie
Coordinator of this site? Confirm its status
MarseilleFranceCompleted
Fondation A. de Rothschild
Coordinator of this site? Confirm its status
ParisFranceCompleted
Assistance Publique Hopitaux de Paris
Coordinator of this site? Confirm its status
ParisFranceCompleted
Theorie Etudes Organisation Recherche En Retine Medicale S.A.R.L.
Coordinator of this site? Confirm its status
ParisFranceCompleted
Societe Civile De Moyens Des Docteurs Maury-Francais-Coscas-Favard-Krivosic
Coordinator of this site? Confirm its status
ParisFranceCompleted
Retina
Coordinator of this site? Confirm its status
Saint-Cyr-Sur-LoireFranceCompleted
Klinički bolnički centar Osijek
Coordinator of this site? Confirm its status
OsijekCroatiaCompleted
Budapesti Bajcsy-Zsilinszky Korhaz Es Rendelointezet
Coordinator of this site? Confirm its status
BudapestHungaryCompleted
Semmelweis University
Coordinator of this site? Confirm its status
Budapest VIIIHungaryCompleted
Budapest Retina Associates Kft.
Coordinator of this site? Confirm its status
Budapest XIIIHungaryCompleted
Barzilai Medical Center
Coordinator of this site? Confirm its status
AshkelonIsraelUnknown status
Carmel Medical Center
Coordinator of this site? Confirm its status
HaifaIsraelUnknown status
Kaplan Medical Center
Coordinator of this site? Confirm its status
RehovotIsraelUnknown status
Shamir Medical Center
Coordinator of this site? Confirm its status
TzrifinIsraelUnknown status
Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico
Coordinator of this site? Confirm its status
BolognaItalyCompleted
Azienda Sanitaria Locale 2 Lanciano Vasto Chieti
Coordinator of this site? Confirm its status
ChietiItalyCompleted
University Hospital Of Ferrara
Coordinator of this site? Confirm its status
FerraraItalyCompleted
Careggi University Hospital
Coordinator of this site? Confirm its status
FlorenceItalyCompleted
ASST Fatebenefratelli Sacco
Coordinator of this site? Confirm its status
MilanItalyCompleted
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Coordinator of this site? Confirm its status
MilanItalyCompleted
Ospedale San Raffaele S.r.l.
Coordinator of this site? Confirm its status
MilanItalyCompleted
Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli
Coordinator of this site? Confirm its status
NaplesItalyCompleted
Azienda Ospedaliera Policlinico Universitario Tor Vergata
Coordinator of this site? Confirm its status
RomeItalyCompleted
Pauls Stradins Clinical University Hospital
Coordinator of this site? Confirm its status
RigaLatviaCompleted
Retina Research Institute of Texas, LLC
Coordinator of this site? Confirm its status
AbileneUnited StatesUnknown status
Retina Consultants of Hawaii, Inc.
Coordinator of this site? Confirm its status
‘AieaUnited StatesUnknown status
Southwest Retina Specialists
Coordinator of this site? Confirm its status
AmarilloUnited StatesUnknown status
Western Carolina Retinal Associates
Coordinator of this site? Confirm its status
AshevilleUnited StatesUnknown status
Retina & Vitreous Center of Southern Oregon, PC
Coordinator of this site? Confirm its status
AshlandUnited StatesUnknown status
Southeast Retina Center, P.C.
Coordinator of this site? Confirm its status
AugustaUnited StatesUnknown status
University of Colorado
Coordinator of this site? Confirm its status
AuroraUnited StatesUnknown status
Austin Retina Associates
Coordinator of this site? Confirm its status
AustinUnited StatesUnknown status
Retina Research of Beaufort
Coordinator of this site? Confirm its status
BeaufortUnited StatesUnknown status
Pacific Northwest Retina
Coordinator of this site? Confirm its status
BellevueUnited StatesUnknown status
Ophthalmic Consultants of Boston
Coordinator of this site? Confirm its status
BostonUnited StatesUnknown status
Retinal Diagnostic Center
Coordinator of this site? Confirm its status
CampbellUnited StatesUnknown status
The Retina Group of Washington
Coordinator of this site? Confirm its status
Chevy ChaseUnited StatesUnknown status
Retina Consultants of Southern CO
Coordinator of this site? Confirm its status
Colorado SpringsUnited StatesUnknown status
Retina Foundation of the Southwest
Coordinator of this site? Confirm its status
DallasUnited StatesUnknown status
Rand Eye Institute
Coordinator of this site? Confirm its status
Deerfield BeachUnited StatesUnknown status
Retina Group of Florida
Coordinator of this site? Confirm its status
Fort LauderdaleUnited StatesUnknown status
Eye Medical Center of Fresno
Coordinator of this site? Confirm its status
FresnoUnited StatesUnknown status
Retina Consultants of Orange County
Coordinator of this site? Confirm its status
FullertonUnited StatesUnknown status
Cumberland Valley Retina Consultants
Coordinator of this site? Confirm its status
HagerstownUnited StatesUnknown status
Southeastern Retina Associates, PC
Coordinator of this site? Confirm its status
KnoxvilleUnited StatesUnknown status
Jacobs Retina Center at The Shiley Eye Institute USCD
Coordinator of this site? Confirm its status
La JollaUnited StatesUnknown status
Colorado Retina Associates, PC
Coordinator of this site? Confirm its status
LakewoodUnited StatesUnknown status
Retina-Vitreous Surgeons of Central New York
Coordinator of this site? Confirm its status
LiverpoolUnited StatesUnknown status
Jules Stein Eye Institute/ David Geffen School of Medicine
Coordinator of this site? Confirm its status
Los AngelesUnited StatesUnknown status
Florida Eye Associates
Coordinator of this site? Confirm its status
MelbourneUnited StatesUnknown status
Ochsner Clinic Foundation
Coordinator of this site? Confirm its status
New OrleansUnited StatesUnknown status
Ophthalmic Consultants of Long Island
Coordinator of this site? Confirm its status
OceansideUnited StatesUnknown status
Retina Care Specialists
Coordinator of this site? Confirm its status
Palm Beach GardensUnited StatesUnknown status
Doheny Eye Center UCLA
Coordinator of this site? Confirm its status
PasadenaUnited StatesUnknown status
Illinois Eye Center
Coordinator of this site? Confirm its status
PeoriaUnited StatesUnknown status
Mid Atlantic Retina - Wills Eye Institute
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesUnknown status
Retina Northwest, PC
Coordinator of this site? Confirm its status
PortlandUnited StatesUnknown status
Eye Health Northwest
Coordinator of this site? Confirm its status
PortlandUnited StatesUnknown status
Black Hills Regional Eye Institute
Coordinator of this site? Confirm its status
Rapid CityUnited StatesUnknown status
Retina Consultants of Southern California
Coordinator of this site? Confirm its status
RedlandsUnited StatesUnknown status
Sierra Eye Associates
Coordinator of this site? Confirm its status
RenoUnited StatesUnknown status
Retina Associates of Western NY
Coordinator of this site? Confirm its status
RochesterUnited StatesUnknown status
Retina Associates of Utah PC
Coordinator of this site? Confirm its status
Salt Lake CityUnited StatesUnknown status
Orange County Retinal Med Group
Coordinator of this site? Confirm its status
Santa AnaUnited StatesUnknown status
Retina Associates of Sarasota
Coordinator of this site? Confirm its status
SarasotaUnited StatesUnknown status
Retina Center of Texas
Coordinator of this site? Confirm its status
SouthlakeUnited StatesUnknown status
Retina Research Institute at New England Retina
Coordinator of this site? Confirm its status
SpringfieldUnited StatesUnknown status
Retina Vitreous Associates of Florida
Coordinator of this site? Confirm its status
St. PetersburgUnited StatesUnknown status
East Florida Eye Institute
Coordinator of this site? Confirm its status
StuartUnited StatesUnknown status
Southern Vitreoretinal Associates
Coordinator of this site? Confirm its status
TallahasseeUnited StatesUnknown status
Retina Consultants of Houston
Coordinator of this site? Confirm its status
The WoodlandsUnited StatesUnknown status
Palmetto Retina Center
Coordinator of this site? Confirm its status
West ColumbiaUnited StatesUnknown status
Associates in Ophthalmology
Coordinator of this site? Confirm its status
West MifflinUnited StatesUnknown status
Vitreo Retinal Consultants & Surgeons
Coordinator of this site? Confirm its status
WichitaUnited StatesUnknown status
Strategic Clinical Research Group, LLC
Coordinator of this site? Confirm its status
Willow ParkUnited StatesUnknown status
Center for Retina & Macula Disease
Coordinator of this site? Confirm its status
Winter HavenUnited StatesUnknown status
Vitreoretinal Associates PC
Coordinator of this site? Confirm its status
WorcesterUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.