NCT05536297CompletedPhase 3
Avacincaptad Pegol Open-Label Extension for Patients With Geographic Atrophy
An Open-label Extension (OLE) Phase 3 Trial to Assess the Safety of Intravitreal Administration of Avacincaptad Pegol (Complement C5 Inhibitor) in Patients With Geographic Atrophy Who Previously Completed Phase 3 Study ISEE2008 (GATHER2)
Source: ClinicalTrials.gov · Last updated 18 May 2026
Brief summary (registry, in English)
The purpose of this study is to assess long-term safety of avacincaptad pegol intravitreal administration for patients with geographic atrophy (GA) who completed Study ISEE2008 (GATHER2) through the Month 23 visit on study treatment (either avacincaptad pegol or Sham).
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 278 (actual)
- First submitted
- 7 Sept 2022
- Start date
- 26 Sept 2022
- Primary completion date
- 10 Apr 2025
- Lead sponsor
- Astellas Pharma Global Development, Inc.
- Diseases
- Macular degeneration
- NCT number
- NCT05536297
- EU CT number
- 2024-515185-13-00
- EudraCT number
- 2022-002860-59
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 278
- From 26 Sept 2022 to the primary completion date, 10 Apr 2025
- 117 sites in 17 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient who had the study drug permanently withdrawn for an AE during ISEE2008 are not eligible.
Other
- Patient did not complete Study ISEE2008 (GATHER2) through the Month 24 visit on study treatment (either avacincaptad pegol or Sham).
- Patient did not enroll into this OLE trial within the 90 day enrollment period.
- Patient who is pregnant or nursing.
Who the study is looking for
- Male or female patients aged 50 years or greater diagnosed with GA inside and/or outside of the fovea who completed Study ISEE2008 (GATHER2) through the Month 24 visit on study treatment.
- Patient must provide new written informed consent for this OLE trial prior to participation.
- Patient must have the ability to return for all trial visits for the duration of the 18-month trial.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (117)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro Oftalmológico Dr. Charles Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Instituto Oftalmologico de Buenos Aires Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Oftar Mendoza Coordinator of this site? Confirm its status | Mendoza | Argentina | Unknown status |
| Oftalmólogos Especialistas Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Microcirugia Ocular Coordinator of this site? Confirm its status | Santa Fe | Argentina | Unknown status |
| Medical University of Graz Coordinator of this site? Confirm its status | Graz | Austria | Completed |
| Medical University of Vienna Coordinator of this site? Confirm its status | Vienna | Austria | Completed |
| Centre for Eye Research Australia Coordinator of this site? Confirm its status | East Melbourne | Australia | Unknown status |
| Sydney Retina Clinic Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| Association Hospitaliere De Bruxelles Et De Schaerbeek Centre Hospitalier Universitaire Brugmann Coordinator of this site? Confirm its status | Brussels | Belgium | Completed |
| Centro de Ensino e Pesquisa do Instituto de Visao Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Unknown status |
| IPEPO Instituto Da Visao Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Universidade Federal de Sao Paulo Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Calgary Retina Consultants Coordinator of this site? Confirm its status | Calgary | Canada | Unknown status |
| St. Joseph's Health Care London Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Retina Centre of Ottawa Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Fundacion Oftalmologica Nacional Coordinator of this site? Confirm its status | Bogotá | Colombia | Unknown status |
| Clinica de Oftalmologia Sandiego Coordinator of this site? Confirm its status | Medellín | Colombia | Unknown status |
| Axon Clinical s.r.o. Coordinator of this site? Confirm its status | Prague 5 | Czechia | Completed |
| Universitaetsklinikum Bonn AöR Coordinator of this site? Confirm its status | Bonn | Germany | Completed |
| University Hospital Cologne AöR Coordinator of this site? Confirm its status | Cologne | Germany | Completed |
| University Medical Center Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Medizinische Hochschule Hannover Coordinator of this site? Confirm its status | Hanover | Germany | Completed |
| Ludwig-Maximilians-Universitaet Muenchen Coordinator of this site? Confirm its status | Munich | Germany | Completed |
| Augenzentrum Am St Franziskus-Hospital Muenster Coordinator of this site? Confirm its status | Munster | Germany | Completed |
| Institut Catala De Retina S.L. Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Centro De Oftalmologia Barraquer S.A. Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Bilboftal S.L. Coordinator of this site? Confirm its status | Bilbao | Spain | Completed |
| Oftalmologia Vistahermosa S.L. Coordinator of this site? Confirm its status | Burjassot | Spain | Completed |
| Metavision Arruzafa S.L. Coordinator of this site? Confirm its status | Cordoba | Spain | Completed |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Completed |
| Valles Ophthalmology Research S.L. Coordinator of this site? Confirm its status | Sant Cugat Del Valles | Spain | Completed |
| Instituto Oftalmologico Gomez-Ulla S.L. Coordinator of this site? Confirm its status | Santiago De Compostela | Spain | Completed |
| Hospital Universitario Rio Hortega Coordinator of this site? Confirm its status | Valladolid | Spain | Completed |
| Hospital Clinico Universitario Lozano Blesa Coordinator of this site? Confirm its status | Zaragoza | Spain | Completed |
| Centre hospitalier Universitaire de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Completed |
| Centre Hospitalier Intercommunal Créteil Coordinator of this site? Confirm its status | Créteil | France | Completed |
| Pole Vision Val d'Ouest Coordinator of this site? Confirm its status | Écully | France | Completed |
| Selarl Centre Ophtalmologique Rabelais Imagerie Laser Et Reeducation De La Basse Vision Coordinator of this site? Confirm its status | Lyon | France | Completed |
| Hospices Civils De Lyon Coordinator of this site? Confirm its status | Lyon Cedex 04 | France | Completed |
| Centre Monticelli Paradis d'Ophtalmologie Coordinator of this site? Confirm its status | Marseille | France | Completed |
| Fondation A. de Rothschild Coordinator of this site? Confirm its status | Paris | France | Completed |
| Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Completed |
| Theorie Etudes Organisation Recherche En Retine Medicale S.A.R.L. Coordinator of this site? Confirm its status | Paris | France | Completed |
| Societe Civile De Moyens Des Docteurs Maury-Francais-Coscas-Favard-Krivosic Coordinator of this site? Confirm its status | Paris | France | Completed |
| Retina Coordinator of this site? Confirm its status | Saint-Cyr-Sur-Loire | France | Completed |
| Klinički bolnički centar Osijek Coordinator of this site? Confirm its status | Osijek | Croatia | Completed |
| Budapesti Bajcsy-Zsilinszky Korhaz Es Rendelointezet Coordinator of this site? Confirm its status | Budapest | Hungary | Completed |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest VIII | Hungary | Completed |
| Budapest Retina Associates Kft. Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Completed |
| Barzilai Medical Center Coordinator of this site? Confirm its status | Ashkelon | Israel | Unknown status |
| Carmel Medical Center Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| Kaplan Medical Center Coordinator of this site? Confirm its status | Rehovot | Israel | Unknown status |
| Shamir Medical Center Coordinator of this site? Confirm its status | Tzrifin | Israel | Unknown status |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Completed |
| Azienda Sanitaria Locale 2 Lanciano Vasto Chieti Coordinator of this site? Confirm its status | Chieti | Italy | Completed |
| University Hospital Of Ferrara Coordinator of this site? Confirm its status | Ferrara | Italy | Completed |
| Careggi University Hospital Coordinator of this site? Confirm its status | Florence | Italy | Completed |
| ASST Fatebenefratelli Sacco Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Ospedale San Raffaele S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Completed |
| Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli Coordinator of this site? Confirm its status | Naples | Italy | Completed |
| Azienda Ospedaliera Policlinico Universitario Tor Vergata Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Pauls Stradins Clinical University Hospital Coordinator of this site? Confirm its status | Riga | Latvia | Completed |
| Retina Research Institute of Texas, LLC Coordinator of this site? Confirm its status | Abilene | United States | Unknown status |
| Retina Consultants of Hawaii, Inc. Coordinator of this site? Confirm its status | ‘Aiea | United States | Unknown status |
| Southwest Retina Specialists Coordinator of this site? Confirm its status | Amarillo | United States | Unknown status |
| Western Carolina Retinal Associates Coordinator of this site? Confirm its status | Asheville | United States | Unknown status |
| Retina & Vitreous Center of Southern Oregon, PC Coordinator of this site? Confirm its status | Ashland | United States | Unknown status |
| Southeast Retina Center, P.C. Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| University of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Austin Retina Associates Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Retina Research of Beaufort Coordinator of this site? Confirm its status | Beaufort | United States | Unknown status |
| Pacific Northwest Retina Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Ophthalmic Consultants of Boston Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Retinal Diagnostic Center Coordinator of this site? Confirm its status | Campbell | United States | Unknown status |
| The Retina Group of Washington Coordinator of this site? Confirm its status | Chevy Chase | United States | Unknown status |
| Retina Consultants of Southern CO Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Retina Foundation of the Southwest Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Rand Eye Institute Coordinator of this site? Confirm its status | Deerfield Beach | United States | Unknown status |
| Retina Group of Florida Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Eye Medical Center of Fresno Coordinator of this site? Confirm its status | Fresno | United States | Unknown status |
| Retina Consultants of Orange County Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Cumberland Valley Retina Consultants Coordinator of this site? Confirm its status | Hagerstown | United States | Unknown status |
| Southeastern Retina Associates, PC Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Jacobs Retina Center at The Shiley Eye Institute USCD Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Colorado Retina Associates, PC Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Retina-Vitreous Surgeons of Central New York Coordinator of this site? Confirm its status | Liverpool | United States | Unknown status |
| Jules Stein Eye Institute/ David Geffen School of Medicine Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Florida Eye Associates Coordinator of this site? Confirm its status | Melbourne | United States | Unknown status |
| Ochsner Clinic Foundation Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Ophthalmic Consultants of Long Island Coordinator of this site? Confirm its status | Oceanside | United States | Unknown status |
| Retina Care Specialists Coordinator of this site? Confirm its status | Palm Beach Gardens | United States | Unknown status |
| Doheny Eye Center UCLA Coordinator of this site? Confirm its status | Pasadena | United States | Unknown status |
| Illinois Eye Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Mid Atlantic Retina - Wills Eye Institute Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Retina Northwest, PC Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Eye Health Northwest Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Black Hills Regional Eye Institute Coordinator of this site? Confirm its status | Rapid City | United States | Unknown status |
| Retina Consultants of Southern California Coordinator of this site? Confirm its status | Redlands | United States | Unknown status |
| Sierra Eye Associates Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Retina Associates of Western NY Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Retina Associates of Utah PC Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Orange County Retinal Med Group Coordinator of this site? Confirm its status | Santa Ana | United States | Unknown status |
| Retina Associates of Sarasota Coordinator of this site? Confirm its status | Sarasota | United States | Unknown status |
| Retina Center of Texas Coordinator of this site? Confirm its status | Southlake | United States | Unknown status |
| Retina Research Institute at New England Retina Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Retina Vitreous Associates of Florida Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| East Florida Eye Institute Coordinator of this site? Confirm its status | Stuart | United States | Unknown status |
| Southern Vitreoretinal Associates Coordinator of this site? Confirm its status | Tallahassee | United States | Unknown status |
| Retina Consultants of Houston Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| Palmetto Retina Center Coordinator of this site? Confirm its status | West Columbia | United States | Unknown status |
| Associates in Ophthalmology Coordinator of this site? Confirm its status | West Mifflin | United States | Unknown status |
| Vitreo Retinal Consultants & Surgeons Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Strategic Clinical Research Group, LLC Coordinator of this site? Confirm its status | Willow Park | United States | Unknown status |
| Center for Retina & Macula Disease Coordinator of this site? Confirm its status | Winter Haven | United States | Unknown status |
| Vitreoretinal Associates PC Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.