NCT05541432Completed
Finding the Optimal Resistance Training Intensity For Your Bones
Finding the Optimal Resistance Training Intensity For Your Bones: A Randomized Controlled Trial (FORTIFY Bones)
Source: ClinicalTrials.gov · Last updated 23 Jul 2026
Brief summary (registry, in English)
Osteoporosis is a bone disease that can result in fractures, disability and an increased risk of premature death. Exercise is recommended for fall and fracture prevention, but health care professionals often recommend walking or lower intensity community exercise classes, which may not be effective for building bone. Further, individuals with osteoporosis are often told to avoid lifting or moving in certain ways, which creates fear and activity avoidance. Conversely, research suggests that to stimulate bone, you need higher loads on bone, with either higher intensity resistance training or impact exercise - the types of things people with low bone mass are told to avoid. Our study will examine different types of exercise intensity and how they translate to building bone in people with low bone mineral density (BMD).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 324 (actual)
- First submitted
- 6 Jul 2022
- Start date
- 13 Sept 2022
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- University of Waterloo
- Diseases
- Osteoporosis
- NCT number
- NCT05541432
What you commit to
- Study type: Interventional
- Participants enrolled: 324
- From 13 Sept 2022 to the primary completion date, 28 Feb 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Takes or has taken medications affecting bone in the last 12 months or longer (as determined by the research team)
- Is receiving palliative care
- Has major surgery planned in the next 12 months
Other illness
- Has conditions affecting bone health
- Has had cancer within the last 2 years (excluding non-melanoma skin cancer)
- Has been diagnosed with dementia
Other
- Is unable to communicate in English
- Has had a clinical or symptomatic spine fracture in the last 12 months, or a lower/upper limb fracture in the last 6 months
- Has had a joint replacement in the last 6 months
- Has planned travel time of greater than 6 weeks
- Is already participating in moderate- or high-intensity progressive resistance training ≥ twice weekly
- Weighs over 450 lbs
- Has contraindications to resistance training
Who the study is looking for
- Age 50 or over
- Has received 2 vaccines for COVID-19
- Has femoral neck, total hip, or lumbar spine BMD T-score of ≤ -1, OR has been or have a FRAX probability of fracture of greater than or equal to 20% for major osteoporotic fracture or 3% or greater for hip fracture.\*
- Individuals at high risk of fracture (i.e., risk in next 10 years is \>20% according to FRAX) should be offered medication for osteoporosis. We will only include individuals at high risk of fracture who have declined medication or who had been on osteoporosis medication and decided to cease taking it in the appropriate timeline (as outlined by PI's and Physician).
- Willing to participate in 2x weekly exercise sessions
- Self-reported as postmenopausal for ≥ 2 years, OR postmenopausal stats confirmed via blood test (female participants only)
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Toronto Coordinator of this site? Confirm its status | Markham | Canada | Unknown status |
| University of Saskatchewan Coordinator of this site? Confirm its status | Saskatoon | Canada | Unknown status |
| University of Waterloo Coordinator of this site? Confirm its status | Waterloo | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.