NCT05543915Completed
Cognitive Markers in Prodromal MS
Intra-Individual Variability in Cognitive Performance as a Marker of Prodromal Disability in MS
Source: ClinicalTrials.gov · Last updated 14 Jul 2025
Brief summary (registry, in English)
The focus of this work is the evaluation of a measure of cognitive functioning- intra-individual variability (IIV) - derived from a computer-based continuous reaction time (RT) task (Cogstate) as an early marker of prodromal MS.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 13 Sept 2022
- Start date
- 9 Feb 2022
- Primary completion date
- 20 Jun 2024
- Lead sponsor
- NYU Langone Health
- Diseases
- Multiple sclerosis
- NCT number
- NCT05543915
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 9 Feb 2022 to the primary completion date, 20 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have any irremovable piercings, metallic based-tattoos, or MRI-contraindicated implants (e.g. pacemakers and defibrillators)
Other illness
- Primary psychiatric disorder that would influence ability to participate.
- Current uncontrolled seizure disorder.
- Current substance abuse disorder.
- History of head trauma in the past year (e.g., head injury, brain surgery) or medical device implanted in the head (such as Deep Brain Stimulator) or in the neck (such as a Vagus Nerve Stimulator).
- Any skin disorder/sensitive skin (e.g., eczema, severe rashes), blisters, open wounds, burn including sunburns, cuts or irritation, or other skin defects which compromise the integrity of the skin at or near stimulation locations (where electrodes are placed)
- Treatment for a communicable skin disorder currently or over the past 12 months
Age
- Presence of severe cognitive impairment (based on SDMT age normative z-score \<-3.0).
Other
- Below average estimated premorbid cognitive functioning (based on WRAT-4 reading recognition standard z-score \< 85).
- Pregnant or breastfeeding
- Additional Exclusion Criteria for tDCS-MRI Participants
- Extreme claustrophobia
Who the study is looking for
- Ages 23-59 years old (inclusive)
- Prodromal MS (defined by radiologically isolated syndrome ≤ 6 months from first MRI or clinically isolated syndrome ≤ 3 months from first clinical event)
Age in the registry: 23 years to 59 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.