NCT05549102Recruiting
CBT and the Neural Circuits of Anxiety
The Impact of CBT on Shock-Potentiated Neural Circuity
Source: ClinicalTrials.gov · Last updated 29 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions. This study aims to provide a theoretical model of the neurobiological mechanisms of CBT's therapeutic effect, where there currently is none, and potentially allow for more targeted/specific approaches to anxiety disorders following the identification of key CBT mechanisms. The ultimate aim is to improve the efficacy of CBT, and more generally, psychological interventions for anxiety disorders.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 174 (estimated)
- First submitted
- 7 Sept 2022
- Start date
- 2 Feb 2020
- Primary completion date
- 1 Dec 2025
- Lead sponsor
- UCLH/UCL Joint Research Office
- NCT number
- NCT05549102
What you commit to
- Study type: Observational
- Planned participants: 174
- From 2 Feb 2020 to the primary completion date, 1 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- MRI contraindications such as pacemaker, aneurysm clip, cochlear implant, neurostimulator, IUD, shrapnel, metal fragments in eye, weight of above 250lbs or claustrophobia
Other illness
- Past/present psychotic disorder, bipolar disorder/mania or alcohol/substance use disorder (outside a comorbid psychiatric episode)
- History of medical illness that may impair cognitive function (e.g. serious head injury, endocrine disorder)
Other
- Score above 22 on the GAD-7
- Current psychotropic pharmacological intervention (e.g. SSRIs) or use within 3 months
- Females who are pregnant, planning pregnancy, or breastfeeding
Who the study is looking for
- Enrolled in IAPT Step 3 (high intensity service)
- Score of or above 8 on the GAD-7 (indicating moderate anxiety on a standard scale of anxiety; Spitzer et al., 2006)
- Willing and able to provide written consent
Age in the registry: 18 years to 64 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institute of Cognitive Neuroscience, University College London Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.