CRC Detection Reliable Assessment With Blood

Prior treatment

• Previous personal history of CRC or precancerous lesions
• Positive result from non-invasive screening test within the associated recommended intervals:
  • 2.1 Fecal occult blood test or fecal immunochemical test within the previous 12 months 2.2 Epi proColon test within the previous 12 months 2.3 FIT-DNA (Cologuard) test within the previous 36 months
• Overt rectal bleeding or bleeding hemorrhoids within previous 30 days
• A colonoscopy within the previous 9 years, with the exception of a failed colonoscopy due to poor bowel preparation

Other illness

• Individuals with relevant familial (hereditary) cancer syndrome, such as:
  • 4.1 Hereditary non-polyposis colorectal cancer syndrome (HNPCC or Lynch Syndrome) 4.2 Peutz-Jeghers Syndrome 4.3 MYH-Associated Polyposis (MAP) 4.4 Gardner's syndrome 4.5Turcot's (or Crail's) syndrome 4.6 Cowden's syndrome, 4.7Juvenile Polyposis 4.8 Cronkhite-Canada syndrome 4.9 Neurofibromatosis 4.10 Familial Hyperplastic Polyposis
• Current diagnosis of any cancer, except non-melanoma skin cancer

Age

• Diagnosed with condition associated with higher risk for colorectal cancer, such as:
  • 3.1 Inflammatory bowel disease (IBD) 3.2 Chronic ulcerative colitis (CUC) 3.3 Crohn's disease 3.4 Familial adenomatous polyposis (FAP) 3.5 Familial history for colorectal cancer 3.5.1 One or more first-degree relatives diagnosed with CRC or adenomatous polyps before 60 years of age 3.5.2 Two or more first degree relatives diagnosed at any age with CRC

Other

• Diagnosed with chronic gastritis or cirrhosis
• Pregnancy

• Participant is 45 years of age or older at time of enrollment.
• Participant is at average risk for development of colorectal cancer (as defined by inclusion and exclusion criteria)
• Participant is able and willing to undergo a screening colonoscopy
• Participant is able and willing to sign informed consent and adhere to study requirements
• Participant is able to provide blood sample prior to colonoscopy (within 90 days of scheduled colonoscopy).