NCT05553704CompletedPhase 2
Metformin in Patients With Ulcerative Colitis Treated With Mesalamine
Clinical Study to Compare the Possible Efficacy of Metformin in Patients With Ulcerative Colitis Treated With Mesalamine
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease characterized by diffused inflammation of the colon and rectum mucosa, however, the exact underlying mechanisms of UC remain poorly understood.UC is strongly dependent on cellular immune reaction and exaggerated inflammatory response due to genetic, immune and environmental factors.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 20 Sept 2022
- Start date
- 1 Nov 2022
- Primary completion date
- 1 Dec 2023
- Lead sponsor
- Tanta University
- Diseases
- Ulcerative colitis
- NCT number
- NCT05553704
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 60
- From 1 Nov 2022 to the primary completion date, 1 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- •
- Breast feeding
- Significant liver and kidney function abnormalities
- Diabetic patients
- Colorectal cancer patients
- Patients with severe UC
- Patients taking rectal or systemic steroids
- Patients taking immunosuppressives or biological therapies
- Addiction to alcohol and / or drugs
- Known allergy to the studied medications
Who the study is looking for
- Age ≥ 18 years
- Both males and females will be included
- Negative pregnancy test and effective contraception
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine, Mansoura University Coordinator of this site? Confirm its status | Al Mansurah | Egypt | Unknown status |
Related publications
- The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study.Front Pharmacol · 2025 · PMID 40191419
- Repurposing metformin as adjuvant therapy in patients with ulcerative colitis treated with mesalamine: A randomized controlled double-blinded study.Int Immunopharmacol · 2024 · PMID 38917525
This page is information, not medical advice. Discuss any trial with your doctor.