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NCT05555979Completed

A Study to Assess Change in Patient Experience in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Venetoclax Tablets + Intravenous Rituximab or Bruton's Tyrosine Kinase Inhibitors Tablets in the United Kingdom

Qualitative, Cross-sectional Observational Study Exploring the Experience of Patients Prescribed Venetoclax+Rituximab or Bruton's Tyrosine Kinase Inhibitors for Chronic Lymphocytic Leukaemia in Clinical Practice in the UK

Source: ClinicalTrials.gov · Last updated 29 Jun 2025

Brief summary (registry, in English)

Chronic lymphocytic leukemia (CLL), a form of Non-Hodgkin's Lymphoma, is the most common type of leukemia in adults, affecting approximately 3,800 people in the UK each year. This study will evaluate the patient experience of CLL in adult participants who are prescribed venetoclax+rituximab or Bruton's tyrosine kinase inhibitors in the United Kingdom (UK). Venetoclax+rituximab is a drug approved to treat CLL. Study participants will receive venetoclax+rituximab as prescribed by their study doctor in accordance with approved local label. Adult participants prescribed venetoclax+rituximab or Bruton's tyrosine kinase inhibitors will be enrolled. Around 140 participants will be enrolled in the study in approximately 10 sites in the UK. Participants will receive venetoclax tablets to be taken by mouth and rituximab intravenous (IV) injection according to the approved local label. There is expected to be no additional burden for participants in this trial. All study visits will occur during routine clinical practice.

Status (registry)
Completed
Study type
Observational
Enrollment
56 (actual)
First submitted
23 Sept 2022
Start date
14 Dec 2022
Primary completion date
10 Apr 2024
Lead sponsor
AbbVie
NCT number
NCT05555979

What you commit to

  • Study type: Observational
  • Participants enrolled: 56
  • From 14 Dec 2022 to the primary completion date, 10 Apr 2024
  • 10 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previously treated with a BTKi, a BCL-2 inhibitor or other investigational agents.

Other illness

  • Has any other medical condition or disorder that, in the opinion of the site investigator or study director, could compromise participant's ability to give written informed consent and/or prevent or interfere with his or her ability to comply with study procedures and provide meaningful information about his or her CLL experience.

Who the study is looking for

  • Has a confirmed diagnosis of chronic lymphocytic leukemia (CLL) (as defined by 2008 Modified International Workshop for Chronic Lymphocytic Leukemia National Cancer Institute Working Group (IWCLL NCI-WG) Guidelines).
  • Has relapsed/refractory (R/R) disease having received only 1 prior line of treatment, which must have been a chemotherapy or chemoimmunotherapy treatment.
  • Has treatment experience with venetoclax+rituximab (Ven+R) or bruton's tyrosine kinase inhibitor (BTKi)s that meets the criteria for inclusion described in the protocol, for which recruitment targets have not yet been met.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (10)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
University Hospitals of Leicester NHS Trust /ID# 252719
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LeicesterUnited KingdomUnknown status
The Royal Marsden NHS Foundation Trust /ID# 252655
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LondonUnited KingdomUnknown status
Barts Health NHS Trust /ID# 252717
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LondonUnited KingdomUnknown status
Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 252720
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NorwichUnited KingdomUnknown status
Nottingham City Hospital /ID# 252716
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NottinghamUnited KingdomUnknown status
Oxford University Hospitals NHS Foundation Trust /ID# 252715
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OxfordUnited KingdomUnknown status
Portsmouth Hospitals University NHS Trust /ID# 252722
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PortsmouthUnited KingdomUnknown status
Sunderland Royal Hospital /ID# 252495
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SunderlandUnited KingdomUnknown status
Taunton and Somerset NHS Foundation Trust /ID# 252721
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TauntonUnited KingdomUnknown status
University Hospitals Sussex NHS Foundation Trust /ID# 252672
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WorthingUnited KingdomUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.