NCT05555979Completed
A Study to Assess Change in Patient Experience in Adult Participants With Chronic Lymphocytic Leukemia (CLL) Receiving Oral Venetoclax Tablets + Intravenous Rituximab or Bruton's Tyrosine Kinase Inhibitors Tablets in the United Kingdom
Qualitative, Cross-sectional Observational Study Exploring the Experience of Patients Prescribed Venetoclax+Rituximab or Bruton's Tyrosine Kinase Inhibitors for Chronic Lymphocytic Leukaemia in Clinical Practice in the UK
Source: ClinicalTrials.gov · Last updated 29 Jun 2025
Brief summary (registry, in English)
Chronic lymphocytic leukemia (CLL), a form of Non-Hodgkin's Lymphoma, is the most common type of leukemia in adults, affecting approximately 3,800 people in the UK each year. This study will evaluate the patient experience of CLL in adult participants who are prescribed venetoclax+rituximab or Bruton's tyrosine kinase inhibitors in the United Kingdom (UK). Venetoclax+rituximab is a drug approved to treat CLL. Study participants will receive venetoclax+rituximab as prescribed by their study doctor in accordance with approved local label. Adult participants prescribed venetoclax+rituximab or Bruton's tyrosine kinase inhibitors will be enrolled. Around 140 participants will be enrolled in the study in approximately 10 sites in the UK. Participants will receive venetoclax tablets to be taken by mouth and rituximab intravenous (IV) injection according to the approved local label. There is expected to be no additional burden for participants in this trial. All study visits will occur during routine clinical practice.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 56 (actual)
- First submitted
- 23 Sept 2022
- Start date
- 14 Dec 2022
- Primary completion date
- 10 Apr 2024
- Lead sponsor
- AbbVie
- Diseases
- Chronic lymphocytic leukaemia
- NCT number
- NCT05555979
What you commit to
- Study type: Observational
- Participants enrolled: 56
- From 14 Dec 2022 to the primary completion date, 10 Apr 2024
- 10 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previously treated with a BTKi, a BCL-2 inhibitor or other investigational agents.
Other illness
- Has any other medical condition or disorder that, in the opinion of the site investigator or study director, could compromise participant's ability to give written informed consent and/or prevent or interfere with his or her ability to comply with study procedures and provide meaningful information about his or her CLL experience.
Who the study is looking for
- Has a confirmed diagnosis of chronic lymphocytic leukemia (CLL) (as defined by 2008 Modified International Workshop for Chronic Lymphocytic Leukemia National Cancer Institute Working Group (IWCLL NCI-WG) Guidelines).
- Has relapsed/refractory (R/R) disease having received only 1 prior line of treatment, which must have been a chemotherapy or chemoimmunotherapy treatment.
- Has treatment experience with venetoclax+rituximab (Ven+R) or bruton's tyrosine kinase inhibitor (BTKi)s that meets the criteria for inclusion described in the protocol, for which recruitment targets have not yet been met.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals of Leicester NHS Trust /ID# 252719 Coordinator of this site? Confirm its status | Leicester | United Kingdom | Unknown status |
| The Royal Marsden NHS Foundation Trust /ID# 252655 Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Barts Health NHS Trust /ID# 252717 Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 252720 Coordinator of this site? Confirm its status | Norwich | United Kingdom | Unknown status |
| Nottingham City Hospital /ID# 252716 Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Unknown status |
| Oxford University Hospitals NHS Foundation Trust /ID# 252715 Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Portsmouth Hospitals University NHS Trust /ID# 252722 Coordinator of this site? Confirm its status | Portsmouth | United Kingdom | Unknown status |
| Sunderland Royal Hospital /ID# 252495 Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Unknown status |
| Taunton and Somerset NHS Foundation Trust /ID# 252721 Coordinator of this site? Confirm its status | Taunton | United Kingdom | Unknown status |
| University Hospitals Sussex NHS Foundation Trust /ID# 252672 Coordinator of this site? Confirm its status | Worthing | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.