NCT05556096Active, not recruitingPhase 3
Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis
Source: ClinicalTrials.gov · Last updated 17 Jun 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the safety and efficacy of ALXN1720 for the treatment of generalized MG (gMG) in adults with autoantibodies against acetylcholine receptor (AChR).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 260 (actual)
- First submitted
- 23 Sept 2022
- Start date
- 21 Nov 2022
- Primary completion date
- 27 May 2025
- Lead sponsor
- Alexion Pharmaceuticals, Inc.
- Diseases
- Myasthenia gravis
- NCT number
- NCT05556096
- EU CT number
- 2023-508284-77-00
- EudraCT number
- 2022-000460-21
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 260
- From 21 Nov 2022 to the primary completion date, 27 May 2025
- 124 sites in 22 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of thymectomy, or any other thymic surgery within 12 months prior to Screening
Other illness
- Untreated thymic malignancy, carcinoma, or thymoma
- History of Neisseria meningitidis infection
Other
- Pregnancy, breastfeeding, or intention to conceive during the course of the study
Who the study is looking for
- Diagnosis of MG with generalized muscle weakness meeting the clinical criteria defined by Myasthenia Gravis Foundation of America (MGFA) Class II, III or IV
- Positive serological test for autoantibodies against AChR
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (124)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| - Coordinator of this site? Confirm its status | CABA | Argentina | Unknown status |
| - Coordinator of this site? Confirm its status | Ciudad de Buenos Aires | Argentina | Unknown status |
| - Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Medizinische Universitaet Innsbruck Coordinator of this site? Confirm its status | Innsbruck | Austria | Active, not recruiting |
| Allgemeines Krankenhaus Der Stadt Wien Universitatskliniken Coordinator of this site? Confirm its status | Vienna | Austria | Active, not recruiting |
| Klinikum Wels-Grieskirchen GmbH Coordinator of this site? Confirm its status | Wels | Austria | Active, not recruiting |
| - Coordinator of this site? Confirm its status | Barretos | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | Joinville | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | Ribeirão Preto | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | Salvador | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | São José do Rio Preto | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| - Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| - Coordinator of this site? Confirm its status | Québec | Canada | Unknown status |
| - Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| - Coordinator of this site? Confirm its status | Sankt Gallen | Switzerland | Unknown status |
| - Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| - Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
| - Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| - Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| - Coordinator of this site? Confirm its status | Fuzhou | China | Unknown status |
| - Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| - Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| - Coordinator of this site? Confirm its status | Qingdao | China | Unknown status |
| - Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| - Coordinator of this site? Confirm its status | Suzhou | China | Unknown status |
| - Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| - Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Active, not recruiting |
| Universitaetsklinikum Duesseldorf AöR Coordinator of this site? Confirm its status | Duesseldorf | Germany | Active, not recruiting |
| Klinikum rechts der Isar der TU Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Active, not recruiting |
| Klinikum Wuerzburg Mitte gGmbH Coordinator of this site? Confirm its status | Wuerzburg | Germany | Active, not recruiting |
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen Oe | Denmark | Active, not recruiting |
| Region Nordjylland Coordinator of this site? Confirm its status | Gistrup | Denmark | Active, not recruiting |
| Hospital Germans Trias i Pujol Coordinator of this site? Confirm its status | Badalona | Spain | Active, not recruiting |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Active, not recruiting |
| Bellvitge University Hospital Coordinator of this site? Confirm its status | L'hospitalet De Llobregat | Spain | Active, not recruiting |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Ramón y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Clínico San Carlos Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Hospital Universitario Regional de Málaga Coordinator of this site? Confirm its status | Málaga | Spain | Active, not recruiting |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Active, not recruiting |
| Hospital Universitario Infanta Sofia Coordinator of this site? Confirm its status | San Sebastián de los Reyes | Spain | Active, not recruiting |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Active, not recruiting |
| Raymond-Poincare Hospital Coordinator of this site? Confirm its status | Garches | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Lille Coordinator of this site? Confirm its status | Lille Cedex | France | Active, not recruiting |
| Centre Hospitalier Regional De Marseille Coordinator of this site? Confirm its status | Marseille | France | Active, not recruiting |
| Centre Hospitalier Universitaire De Montpellier Coordinator of this site? Confirm its status | Montpellier Cedex 5 | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Nice Coordinator of this site? Confirm its status | Nice | France | Active, not recruiting |
| Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Active, not recruiting |
| Les Hopitaux Universitaires De Strasbourg Coordinator of this site? Confirm its status | Strasbourg Cedex 2 | France | Active, not recruiting |
| - Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Unknown status |
| - Coordinator of this site? Confirm its status | Hadera | Israel | Unknown status |
| - Coordinator of this site? Confirm its status | Haifa | Israel | Unknown status |
| - Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Azienda Ospedaliera Papa Giovanni XXIII Coordinator of this site? Confirm its status | Bergamo | Italy | Active, not recruiting |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Coordinator of this site? Confirm its status | Brescia | Italy | Active, not recruiting |
| Careggi University Hospital Coordinator of this site? Confirm its status | Florence | Italy | Active, not recruiting |
| Università degli studi di Napoli Federico II Coordinator of this site? Confirm its status | Naples | Italy | Active, not recruiting |
| Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Coordinator of this site? Confirm its status | Palermo | Italy | Active, not recruiting |
| Azienda Ospedaliero Universitaria Pisana Coordinator of this site? Confirm its status | Pisa | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Azienda Ospedaliero-Universitaria Sant Andre Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| - Coordinator of this site? Confirm its status | Chiba | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Fukushima | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Higashimatsuyama-shi | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Isehara-shi | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Kawasaki-shi | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Morioka | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Nagasaki | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Nagoya | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Shinjuku-ku | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Suita-shi | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | tabashi City | Japan | Unknown status |
| - Coordinator of this site? Confirm its status | Busan | South Korea | Unknown status |
| - Coordinator of this site? Confirm its status | Daegu | South Korea | Unknown status |
| - Coordinator of this site? Confirm its status | Gwangju | South Korea | Unknown status |
| - Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Amsterdam UMC Stichting Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Completed |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Active, not recruiting |
| Krakowska Akademia Neurologii Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Krakowski Szpital Specjalistyczny Im. Sw. Jana Pawla II Coordinator of this site? Confirm its status | Cracow | Poland | Active, not recruiting |
| Neurologia Śląska Centrum Medyczne Coordinator of this site? Confirm its status | Katowice | Poland | Active, not recruiting |
| Niepubliczny Zaklad Opieki Zdrowotnej Neuromed M. I M. Nastaj. sp.p. Coordinator of this site? Confirm its status | Lublin | Poland | Active, not recruiting |
| Clinical Research Center Sp z o o Medic R Sp k Coordinator of this site? Confirm its status | Poznan | Poland | Active, not recruiting |
| Unidade Local De Saude De Almada-Seixal E.P.E. Coordinator of this site? Confirm its status | Almada | Portugal | Active, not recruiting |
| Unidade Local De Saude De Santo Antonio E.P.E. Coordinator of this site? Confirm its status | Porto | Portugal | Active, not recruiting |
| - Coordinator of this site? Confirm its status | Belgrade | Serbia | Unknown status |
| - Coordinator of this site? Confirm its status | Niš | Serbia | Unknown status |
| - Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Unknown status |
| - Coordinator of this site? Confirm its status | New Taipei City | Taiwan | Unknown status |
| - Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| - Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| - Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Bradenton | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| - Coordinator of this site? Confirm its status | East Lansing | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Fort Collins | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Maitland | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Morgantown | United States | Unknown status |
| - Coordinator of this site? Confirm its status | North Charleston | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Patchogue | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Savannah | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Syracuse | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| - Coordinator of this site? Confirm its status | Bursa | Turkey (Türkiye) | Unknown status |
| - Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
| - Coordinator of this site? Confirm its status | Kocaeli | Turkey (Türkiye) | Unknown status |
| - Coordinator of this site? Confirm its status | Samsun | Turkey (Türkiye) | Unknown status |
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This page is information, not medical advice. Discuss any trial with your doctor.