NCT05561205Recruiting
rTMS for Apathy Clinical Trial
Repetitive Transcranial Magnetic Stimulation for Apathy Clinical Trial (REACT)
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in neurocognitive disorders and mild behavioural impairment in individuals receiving methylphenidate and individuals not receiving medication for apathy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 27 Sept 2022
- Start date
- 9 Feb 2023
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Sunnybrook Health Sciences Centre
- Diseases
- Alzheimer disease
- NCT number
- NCT05561205
What you commit to
- Study type: Interventional
- Planned participants: 10
- From 9 Feb 2023 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking an amphetamine product
Other illness
- Central nervous system abnormalities, Tourette's syndrome, or motor tics
Other
- Current major depressive episode
- Agitation, delusions, hallucination
- Medical contraindications to rTMS
- Current participation in another clinical trial
Who the study is looking for
- mild or major neurocognitive disorder OR mild behavioural impairment
- Apathy for at least 4 weeks
- Stable dose of medication (\>4 weeks) that may affect cognition or behaviour
- Care partner who spends at least 10 hours a week with the subject
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sunnybrook Health Sciences Centre Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.