NCT05564403Active, not recruitingPhase 2
Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)
FOLFOX in Combination With Binimetinib as 2nd Line Therapy for Patients With Advanced Biliary Tract Cancers With MAPK Pathway Alterations: A ComboMATCH Treatment Trial
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
This phase II ComboMATCH treatment trial compares the usual treatment of modified leucovorin, fluorouracil and oxaliplatin (mFOLFOX6) chemotherapy to using binimetinib plus mFOLFOX6 chemotherapy to shrink tumors in patients with biliary tract cancers that have spread to other places in the body (advanced) and had progression of cancer after previous treatments (2nd line setting). Fluorouracil is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in the body. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It works by killing tumor cells. Leucovorin may help the other drugs in the mFOLFOX6 chemotherapy regimen work better by making tumor cells more sensitive to the drugs. Binimetinib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals tumor cells to multiply. This helps to stop or slow the spread of tumor cells. Giving binimetinib in combination with mFOLFOX6 chemotherapy may be effective in shrinking or stabilizing advanced biliary tract cancers in the 2nd line setting.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 17 (actual)
- First submitted
- 27 Sept 2022
- Start date
- 9 Feb 2024
- Primary completion date
- 8 Aug 2026
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT05564403
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 17
- From 9 Feb 2024 to the primary completion date, 8 Aug 2026
- 207 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patient must have enrolled onto EAY191 and must have been given a treatment assignment to ComboMATCH to EAY191-A6 based on the presence of an actionable mutation as defined in EAY191
- GENERAL COMBOMATCH EAY191:
- Patients must be registered to the ComboMATCH Registration Protocol (EAY191)
- Patients must have RAS/RAF/MEK/ERK mutations as determined by the ComboMATCH screening assessment
- Patients must not have BRAF V600E as determined by the ComboMATCH screening assessment
- Patients must have disease that can be safely biopsied and agree to a pre-treatment biopsy or have archival tissue available from within 12 months prior to registration on the ComboMATCH Registration Trial (EAY191).
- Please note the current actionable marker of interest (aMOI)/actionable alteration list for this treatment trial can be found on the Cancer Trials Support Unit (CTSU) website
- Please note novel/Dynamic aMOI can be submitted for review per the process described in the ComboMATCH Registration Protocol
- EAY191-A6 REGISTRATION:
- Participants must have histologically confirmed BTC (intrahepatic cholangiocarcinoma \[IHC\], extrahepatic cholangiocarcinoma \[EHC\] or gallbladder cancer \[GBC\]) that is unresectable or recurrent with a confirmed RAS/RAF/MEK/ERK pathway mutation via any Clinical Laboratory Improvement Act (CLIA)-certified method. BRAFV600E mutations are not eligible due to other ongoing/upcoming studies in this disease cohort
- Tumor tissue must be available:
- Adequate archival tumor specimen (obtained within 12 months of EAY191 registration which has not had a Response Evaluation Criteria in Solid Tumors (RECIST) response, complete response (CR) or partial response (PR), to any intervening therapy after collection of the tissue) must be available with formalin-fixed paraffin-embedded tumor tissue (blocks or slides) OR
- Consent to a new tumor tissue biopsy which is not a representative target lesion. This lesion must be amenable to a minimal risk image-guided or direct vision biopsy
- A new biopsy is preferred but is not required for enrollment in EAY191-A6 if sufficient archival tissue is available as described above.
- Measurable disease per RECIST 1.1 Of note, in the case when a baseline biopsy is done after scans are obtained, a lesion separate from one that is biopsied needs to be measurable per RECIST 1.1. All radiologic studies must be performed within 28 days prior to registration
- Progression of disease on gemcitabine based first-line regimen (i.e. only one prior line of therapy is permitted)
- No systemic anti-cancer therapy within 4 weeks of registration to EAY191-A6
- No prior MEK inhibitor therapy
- No prior history of treatment with a direct and specific inhibitor of KRAS
- Patients who only received radio-sensitizing chemotherapy with fluorouracil (5-FU) or capecitabine are eligible, but need to have received and failed first-line systemic chemotherapy upon recurrence. Peri-operative systemic 5-FU/capecitabine and/or oxaliplatin, is allowed if it's been more than 12 months of registration to EAY191-A6
- No major surgery within 4 weeks (excluding placement of vascular access) of registration to EAY191-A6
- No minor surgery within 2 weeks of registration to EAY191-A6
- No palliative radiotherapy within 1 week of registration to EAY191-A6
- Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown
- Therefore, for women of childbearing potential only, a negative pregnancy test done =\< 14 days prior to registration is required
- Adequate contraception is needed for at least 30 days after the last dose of binimetinib and breastfeeding should be discontinued for at least 3 days after the last dose of binimetinib. For FOLFOX regimen, 9 months is recommended for contraception after last dose of oxaliplatin for females of childbearing potential and 6 months for males
- Age \>= 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 (Karnofsky \>= 60%)
- Absolute neutrophil count (ANC) \>= 1,000/mm\^3, no growth factor within 14 days of 1st dose
- Platelet count \>= 75,000/mm\^3
- Creatinine \< 1.6 x upper limit of normal (ULN) OR
- Calculated (Calc.) creatinine clearance \>= 50 mL/min, as calculated by the Cockcroft-Gault formula
- Total bilirubin =\< 2.0 x upper limit of normal (ULN); Patients with Gilbert syndrome may enroll if \< 3.0 x ULN
- Aspartate aminotransferase (AST) /alanine aminotransferase (ALT) =\< 5.0 x upper limit of normal (ULN)
- Hemoglobin \>= 8 g/dL, no transfusion within 7 days of 1st dose
- Creatine phosphokinase =\< 2.5 x ULN
- High blood pressure more than 160/90 despite treatment are ineligible
- No history of interstitial lung disease. No history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan
- Patients should not have history of bowel perforation or intestinal fistulas in the last 6 months
- Patients with the inability to swallow oral medications or impaired gastrointestinal absorption due to gastrectomy or active inflammatory bowel disease are ineligible
- Must have adequate cardiac function with left ventricular ejection fraction \>= 50% by echocardiography (ECHO) or multiple-gated acquisition (MUGA) scan. Patients with congenital long QT syndrome are not permitted
- No history of prolonged QTc or at risk for prolonged QTc due to any reason (for example, concomitant medications during or before chemotherapy that may increase the risk of prolonged QTc), uncontrolled congestive heart failure, prior history of class III/ IV cardiac disease (New York Heart Association \[NYHA\]), myocardial infarction within the last 6 months, unstable arrhythmias, unstable angina or severe obstructive pulmonary disease
- No active skin disorder that has required systemic therapy within the past 1 year
- No history of rhabdomyolysis
- No concurrent ocular disorders, including:
- Patients with history of glaucoma, history of retinal vein occlusion (RVO), predisposing factors for RVO, including but not limited to uncontrolled hypertension, uncontrolled diabetes
- Patients with history of retinal pathology or evidence of visible retinal pathology that is considered a risk factor for RVO, intraocular pressure \> 21 mm Hg as measured by tonometry, or other significant ocular pathology, such as anatomical abnormalities that increase the risk for RVO
- Patients with a history of corneal erosion (instability of corneal epithelium), corneal degeneration, active or recurrent keratitis, and other forms of serious ocular surface inflammatory conditions
- Patients with known or at risk for retinopathies, uveitis or retinal vein occlusion
- No patients with a history of hypersensitivity to any of the inactive ingredients in binimetinib, nor known severe allergic reactions or hypersensitivity of 5-FU, leucovorin (LV) or oxaliplatin will be allowed to participate in this study for safety concerns
- No other medical condition (e.g. cardiac, gastrointestinal, pulmonary, psychiatric, neurological, genetic, etc.) that in the opinion of the investigator would places the subject at unacceptably high risk for toxicity
- No prior allogeneic stem cell or solid organ transplantation
- Central nervous system (CNS) metastases must have been treated with local therapy (surgery, radiation, ablation) with systemic steroids tapered to a physiologic dose (10 mg or prednisone equivalent or less)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
- Patients must not have grade 2 neuropathy or greater, within 14 days prior to registration
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (207)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hawaii Cancer Care - Westridge Coordinator of this site? Confirm its status | ‘Aiea | United States | Unknown status |
| University of New Mexico Cancer Center Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Lehigh Valley Hospital-Cedar Crest Coordinator of this site? Confirm its status | Allentown | United States | Unknown status |
| UPMC Altoona Coordinator of this site? Confirm its status | Altoona | United States | Unknown status |
| Community Hospital of Anaconda Coordinator of this site? Confirm its status | Anaconda | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Coordinator of this site? Confirm its status | Ankeny | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| University of Michigan Rogel Cancer Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| ThedaCare Regional Cancer Center Coordinator of this site? Confirm its status | Appleton | United States | Unknown status |
| Duluth Clinic Ashland Coordinator of this site? Confirm its status | Ashland | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Aventura Coordinator of this site? Confirm its status | Aventura | United States | Unknown status |
| University of Maryland/Greenebaum Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Advocate Good Shepherd Hospital Coordinator of this site? Confirm its status | Barrington | United States | Unknown status |
| Nebraska Medicine-Bellevue Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Sanford Joe Lueken Cancer Center Coordinator of this site? Confirm its status | Bemidji | United States | Unknown status |
| ThedaCare Cancer Care - Berlin Coordinator of this site? Confirm its status | Berlin | United States | Unknown status |
| National Institutes of Health Clinical Center Coordinator of this site? Confirm its status | Bethesda | United States | Unknown status |
| Walter Reed National Military Medical Center Coordinator of this site? Confirm its status | Bethesda | United States | Unknown status |
| Lehigh Valley Hospital - Muhlenberg Coordinator of this site? Confirm its status | Bethlehem | United States | Unknown status |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| University of Alabama at Birmingham Cancer Center Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Sanford Bismarck Medical Center Coordinator of this site? Confirm its status | Bismarck | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Saint Luke's Cancer Institute - Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Bozeman Health Deaconess Hospital Coordinator of this site? Confirm its status | Bozeman | United States | Unknown status |
| Lafayette Family Cancer Center-EMMC Coordinator of this site? Confirm its status | Brewer | United States | Unknown status |
| University of Michigan - Brighton Center for Specialty Care Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Trinity Health Medical Center - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| Aurora Cancer Care-Southern Lakes VLCC Coordinator of this site? Confirm its status | Burlington | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Caldwell Coordinator of this site? Confirm its status | Caldwell | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Trinity Health Medical Center - Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Miami Valley Hospital South Coordinator of this site? Confirm its status | Centerville | United States | Unknown status |
| University of Virginia Cancer Center Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Unknown status |
| Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Unknown status |
| Advocate Illinois Masonic Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| John H Stroger Jr Hospital of Cook County Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Chicago Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Siteman Cancer Center at Saint Peters Hospital Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Collierville Coordinator of this site? Confirm its status | Collierville | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Golden Triangle Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| UT MD Anderson - The Woodlands Coordinator of this site? Confirm its status | Conroe | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Coral Gables Coordinator of this site? Confirm its status | Coral Gables | United States | Unknown status |
| Siteman Cancer Center at West County Hospital Coordinator of this site? Confirm its status | Creve Coeur | United States | Unknown status |
| AMG Crystal Lake - Oncology Coordinator of this site? Confirm its status | Crystal Lake | United States | Unknown status |
| Aurora Saint Luke's South Shore Coordinator of this site? Confirm its status | Cudahy | United States | Unknown status |
| UPMC Western Maryland Coordinator of this site? Confirm its status | Cumberland | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Miami Valley Hospital Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Dayton Physician LLC - Englewood Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital North Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Premier Blood and Cancer Center Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Corewell Health Dearborn Hospital Coordinator of this site? Confirm its status | Dearborn | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach Coordinator of this site? Confirm its status | Deerfield Beach | United States | Unknown status |
| Essentia Health - Deer River Clinic Coordinator of this site? Confirm its status | Deer River | United States | Unknown status |
| Northwestern Medicine Cancer Center Kishwaukee Coordinator of this site? Confirm its status | DeKalb | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Advocate Good Samaritan Hospital Coordinator of this site? Confirm its status | Downers Grove | United States | Unknown status |
| Essentia Health Cancer Center Coordinator of this site? Confirm its status | Duluth | United States | Unknown status |
| Pocono Medical Center Coordinator of this site? Confirm its status | East Stroudsburg | United States | Unknown status |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Unknown status |
| Swedish Cancer Institute-Edmonds Coordinator of this site? Confirm its status | Edmonds | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Advocate Sherman Hospital Coordinator of this site? Confirm its status | Elgin | United States | Unknown status |
| UPMC Hillman Cancer Center Erie Coordinator of this site? Confirm its status | Erie | United States | Unknown status |
| The Queen's Medical Center - West Oahu Coordinator of this site? Confirm its status | ‘Ewa Beach | United States | Unknown status |
| Inova Schar Cancer Institute Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Inova Fairfax Hospital Coordinator of this site? Confirm its status | Falls Church | United States | Unknown status |
| Sanford Roger Maris Cancer Center Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Sanford Broadway Medical Center Coordinator of this site? Confirm its status | Fargo | United States | Unknown status |
| Parkland Health Center - Farmington Coordinator of this site? Confirm its status | Farmington | United States | Unknown status |
| Corewell Health Farmington Hills Hospital Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Cancer Hematology Centers - Flint Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Genesee Hematology Oncology PC Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Atrium Medical Center-Middletown Regional Hospital Coordinator of this site? Confirm its status | Franklin | United States | Unknown status |
| Saint Luke's Cancer Institute - Fruitland Coordinator of this site? Confirm its status | Fruitland | United States | Unknown status |
| UF Health Cancer Institute - Gainesville Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Northwestern Medicine Cancer Center Delnor Coordinator of this site? Confirm its status | Geneva | United States | Unknown status |
| Aurora Health Care Germantown Health Center Coordinator of this site? Confirm its status | Germantown | United States | Unknown status |
| Northwestern Medicine Glenview Outpatient Center Coordinator of this site? Confirm its status | Glenview | United States | Unknown status |
| Aurora Cancer Care-Grafton Coordinator of this site? Confirm its status | Grafton | United States | Unknown status |
| Northwestern Medicine Grayslake Outpatient Center Coordinator of this site? Confirm its status | Grayslake | United States | Unknown status |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Aurora BayCare Medical Center Coordinator of this site? Confirm its status | Green Bay | United States | Unknown status |
| UPMC Cancer Centers - Arnold Palmer Pavilion Coordinator of this site? Confirm its status | Greensburg | United States | Unknown status |
| Miami Valley Cancer Care and Infusion Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Baptist Cancer Center-Grenada Coordinator of this site? Confirm its status | Grenada | United States | Unknown status |
| Advocate South Suburban Hospital Coordinator of this site? Confirm its status | Hazel Crest | United States | Unknown status |
| Lehigh Valley Hospital-Hazleton Coordinator of this site? Confirm its status | Hazleton | United States | Unknown status |
| Essentia Health Hibbing Clinic Coordinator of this site? Confirm its status | Hibbing | United States | Unknown status |
| Hawaii Cancer Care Inc - Waterfront Plaza Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Queen's Medical Center Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Queen's Cancer Center - Kuakini Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| Queen's Cancer Cenrer - POB I Coordinator of this site? Confirm its status | Honolulu | United States | Unknown status |
| UT MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| UT MD Anderson - West Houston Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Swedish Cancer Institute-Issaquah Coordinator of this site? Confirm its status | Issaquah | United States | Unknown status |
| Mayo Clinic in Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Coordinator of this site? Confirm its status | Jonesboro | United States | Unknown status |
| Logan Health Medical Center Coordinator of this site? Confirm its status | Kalispell | United States | Unknown status |
| Aurora Cancer Care-Kenosha South Coordinator of this site? Confirm its status | Kenosha | United States | Unknown status |
| Kettering Medical Center Coordinator of this site? Confirm its status | Kettering | United States | Unknown status |
| UC San Diego Moores Cancer Center Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| University of Michigan Health - Sparrow Lansing Coordinator of this site? Confirm its status | Lansing | United States | Unknown status |
| OptumCare Cancer Care at Charleston Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| UT MD Anderson - League City Coordinator of this site? Confirm its status | League City | United States | Unknown status |
| University of Kentucky/Markey Cancer Center Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Condell Memorial Hospital Coordinator of this site? Confirm its status | Libertyville | United States | Unknown status |
| AMG Libertyville - Oncology Coordinator of this site? Confirm its status | Libertyville | United States | Unknown status |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Unknown status |
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Henry Ford Saint John Hospital - Macomb Medical Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| Saint John's Hospital - Healtheast Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Aurora Bay Area Medical Group-Marinette Coordinator of this site? Confirm its status | Marinette | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Coordinator of this site? Confirm its status | Mechanicsburg | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Memphis Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Saint Luke's Cancer Institute - Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Kendall Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| University of Miami Miller School of Medicine-Sylvester Cancer Center Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Aurora Cancer Care-Milwaukee Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Aurora Sinai Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Aurora Saint Luke's Medical Center Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| University of South Alabama Mitchell Cancer Institute Coordinator of this site? Confirm its status | Mobile | United States | Unknown status |
| UPMC Hillman Cancer Center - Monroeville Coordinator of this site? Confirm its status | Monroeville | United States | Unknown status |
| West Virginia University Healthcare Coordinator of this site? Confirm its status | Morgantown | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Saint Luke's Cancer Institute - Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| ThedaCare Regional Medical Center - Neenah Coordinator of this site? Confirm its status | Neenah | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Union County Coordinator of this site? Confirm its status | New Albany | United States | Unknown status |
| UC Comprehensive Cancer Center at Silver Cross Coordinator of this site? Confirm its status | New Lenox | United States | Unknown status |
| Advocate Christ Medical Center Coordinator of this site? Confirm its status | Oak Lawn | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Nebraska Medicine-Village Pointe Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Ontario Coordinator of this site? Confirm its status | Ontario | United States | Unknown status |
| Northwestern Medicine Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Unknown status |
| University of Chicago Medicine-Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Unknown status |
| Vince Lombardi Cancer Clinic - Oshkosh Coordinator of this site? Confirm its status | Oshkosh | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Oxford Coordinator of this site? Confirm its status | Oxford | United States | Unknown status |
| Advocate Lutheran General Hospital Coordinator of this site? Confirm its status | Park Ridge | United States | Unknown status |
| Mayo Clinic Hospital in Arizona Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UPMC-Passavant Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UM Sylvester Comprehensive Cancer Center at Plantation Coordinator of this site? Confirm its status | Plantation | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Unknown status |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Unknown status |
| Aurora Cancer Care-Racine Coordinator of this site? Confirm its status | Racine | United States | Unknown status |
| Renown Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Valley Medical Center Coordinator of this site? Confirm its status | Renton | United States | Unknown status |
| Virginia Cancer Institute Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| VCU Massey Cancer Center at Stony Point Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| VCU Massey Comprehensive Cancer Center Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Corewell Health William Beaumont University Hospital Coordinator of this site? Confirm its status | Royal Oak | United States | Unknown status |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Unknown status |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Kootenai Clinic Cancer Services - Sandpoint Coordinator of this site? Confirm its status | Sandpoint | United States | Unknown status |
| Essentia Health Sandstone Coordinator of this site? Confirm its status | Sandstone | United States | Unknown status |
| Swedish Medical Center-First Hill Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Vince Lombardi Cancer Clinic-Sheboygan Coordinator of this site? Confirm its status | Sheboygan | United States | Unknown status |
| Memorial Hospital East Coordinator of this site? Confirm its status | Shiloh | United States | Unknown status |
| Sanford USD Medical Center - Sioux Falls Coordinator of this site? Confirm its status | Sioux Falls | United States | Unknown status |
| Sanford Cancer Center Oncology Clinic Coordinator of this site? Confirm its status | Sioux Falls | United States | Unknown status |
| Baptist Memorial Hospital and Cancer Center-Desoto Coordinator of this site? Confirm its status | Southhaven | United States | Unknown status |
| VCU Community Memorial Health Center Coordinator of this site? Confirm its status | South Hill | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Siteman Cancer Center-South County Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Siteman Cancer Center at Christian Hospital Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| UT MD Anderson - Sugar Land Coordinator of this site? Confirm its status | Sugar Land | United States | Unknown status |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Unknown status |
| Aurora Medical Center in Summit Coordinator of this site? Confirm its status | Summit | United States | Unknown status |
| Corewell Health Beaumont Troy Hospital Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Upper Valley Medical Center Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Vince Lombardi Cancer Clinic-Two Rivers Coordinator of this site? Confirm its status | Two Rivers | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Essentia Health Virginia Clinic Coordinator of this site? Confirm its status | Virginia | United States | Unknown status |
| Northwestern Medicine Cancer Center Warrenville Coordinator of this site? Confirm its status | Warrenville | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Coordinator of this site? Confirm its status | Waukee | United States | Unknown status |
| Aurora Cancer Care-Milwaukee West Coordinator of this site? Confirm its status | Wauwatosa | United States | Unknown status |
| Aurora West Allis Medical Center Coordinator of this site? Confirm its status | West Allis | United States | Unknown status |
| Presbyterian Intercommunity Hospital Coordinator of this site? Confirm its status | Whittier | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Coordinator of this site? Confirm its status | Ypsilanti | United States | Unknown status |
| Huron Gastroenterology PC Coordinator of this site? Confirm its status | Ypsilanti | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.