PEARLDIFER - A Phase II study of pemigatinib after curative local therapy in locally advanced intrahepatic cholangiocarcinoma (iCCA) harboring FGFR2 fusions/rearrangements

Prior treatment

• Presence of tumors other than biliary tract cancer or a secondary tumor other than squamous or basal cell carcinomas of the skin or in situ carcinomas of the cervix which have been effectively treated. The Sponsor decides to include patients who have received curative treatment and have been disease-free for at least 3 years.
• History of hypovitaminosis D requiring supraphysiologic doses (eg, 50,000 UI/weekly) to replenish the deficiency. NOTE: Participants receiving vitamin D supplements are eligible.
• Use of any potent CYP3A4 inhibitors or inducers or moderate CYP3A4 inducers within 14 days or 5 half-lives (whichever is longer) before the first dose of study treatment. NOTE: Moderate CYP3A4 inhibitors are not prohibited (refer to section 24.3 Appendix 3 for a list of CYP3A4 inhibitors and inducers).
• Any other serious concomitant or medical condition that, in the opinion of the investigator, presents a high risk of complications to the patient or reduces the likelihood of clinical effect.
• On-treatment participation in another interventional clinical study in the period 30 days prior to inclusion and during the study.
• Simultaneous, ongoing systemic immunotherapy, chemotherapy, or hormone therapy not described in the study protocol.
• Simultaneous treatment with a different anti-cancer therapy other than that provided in the study (excluding palliative radiotherapy only for symptom control).
• Previous therapy with an FGFR-inhibitor.
• Other serious illnesses or medical ailments within the last 12 months prior to the start of the study.

Other illness

• Current evidence of clinically significant corneal (including but not limited to bullous/band keratopathy, corneal abrasion, inflammation/ulceration, and keratoconjunctivitis) or retinal disorder (including but not limited to central serous retinopathy, macular/retinal degeneration, diabetic retinopathy, retinal detachment) as confirmed by ophthalmologic examination.
• Presence of an active, uncontrollable infection.
• Has active infection with SARS-CoV-2 (positive antigen test in routine testing at site).
• Chronic inflammatory bowel disease.
• Metastatic biliary tract cancer (intrahepatic, hilar, or distal CCA as well as gallbladder carcinoma) disease.
• Pretreatment with any systemic anti-cancer therapy. NOTE: initiation of conventional adjuvant systemic therapy without signs of PD for bridging the time gap to achieve FGFR2-results might be permitted - only after consultation with the LKP.
• Stage B cirrhosis according to Child-Pugh criteria (or worse) or cirrhosis (of any grade) with a history of hepatic encephalopathy or clinically significant ascites resulting from cirrhosis. Clinically significant ascites is defined as ascites resulting from cirrhosis requiring diuretics or paracentesis.
• Known allergic / hypersensitive reactions to at least one of the treatment components.

Lab values

• History of calcium and phosphate hemostasis disorder or systemic mineral imbalance with ectopic calcification of soft tissues (exception: commonly observed calcifications in soft tissues, such as the skin, kidney, tendons or vessels due to injury, disease, and aging, in the absence of systemic mineral imbalance).

Other

• Active disseminated intravascular coagulation.
• Patient pregnant or breast feeding, or planning to become pregnant
• Patient in a closed institution according to an authority or court decision.
• Subjects that are depending on the Sponsor/CRO or investigational site as well as on the investigator.

• Signed informed consent form (ICF).
• Appropriate hematological, hepatic and renal function: (a) Absolute number of neutrophils ≥ 1.5 x 10^9/L; (b) Platelets ≥ 100 x 10^9/L; (c) Hemoglobin ≥ 9 g/dL (5.58 mmol/L); (d) Total bilirubin ≤ 1.5 times the upper limit of normal (ULN); (e) AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN; AP ≤ 5 x ULN.
• Serum creatinine ≤ 1.5 x ULN or creatinine clearance (measured by 24h urine) ≥ 40 mL/min (i.e., if the serum creatinine level is > 1.5 x ULN, then a 24-h urine test must be performed to check the creatinine clearance to be determined).
• Adequate coagulability, as determined by the International Normalized Ratio (INR) ≤ 1.5 and partial thromboplastin time (PTT) ≤ 5 s above the ULN (unless anti-coagulation therapy has been given). Patients receiving warfarin / Phenoprocoumon must be switched to low molecular weight heparin before starting any study-specific procedures.
• Patients infected with human immunodeficiency virus (HIV) are eligible if they meet all the following criteria: (a) CD4 count is ≥350 cells/uL, viral load is undetectable, and not taking prohibited cytochrome (CYP)-interacting medications; (b) Probable long-term survival with HIV if cancer were not present; (c) Stable on a highly active antiretroviral therapy (HAART) regimen for ≥4 weeks and willing to adhere to their HAART regimen with minimal overlapping toxicity and drug-drug interactions with the experimental agents in this study; (d) HIV is not multi-drug resistant; (e) Taking medication and/or receiving antiretroviral therapy that does not interact or have overlapping toxicities with the study medication
• Subject is willing and able to comply with the protocol (including contraceptive measures) for the duration of the study including undergoing treatment, and scheduled visits and examinations including follow up.
• For patients with active hepatitis B virus (HBV): HBV DNA ≤ 500 IU/mL obtained within 28 days prior to initiation of study treatment, AND Anti-HBV treatment (per local standard of care e.g. entecavir) prior to study entry and willingness to continue treatment for the length of the study.
• For patients with active hepatitis C virus (HCV): Patients positive for HCV antibody are eligible, also if polymerase chain reaction testing is positive for HCV RNA; however, anti-viral therapy against HCV is only allowed prior to trial but not during the trial.
• Patients infected with human immunodeficiency virus (HIV) are eligible if they meet all the following criteria: (a) CD4 count is ≥350 cells/uL, viral load is undetectable, and not taking prohibited cytochrome (CYP)-interacting medications; (b) Probable long-term survival with HIV if cancer were not present; (c) Stable on a highly active antiretroviral therapy (HAART) regimen for ≥4 weeks and willing to adhere to their HAART regimen with minimal overlapping toxicity and drug-drug interactions with the experimental agents in this study; (d) HIV is not multi-drug resistant; (e) Taking medication and/or receiving antiretroviral therapy that does not interact or have overlapping toxicities with the study medication
• Patients*, age ≥ 18 years at the time of signing the informed consent form. (*There are no data that indicate special gender distribution. Therefore, patients will be enrolled in the study gender-independently.)
• Histologically proven and curatively treatable localized intrahepatic biliary tract cancer (iCCA only), without signs of metastatic disease, and proven FGRF2-fusions/rearrangements, identified by routine FISH or by NGS testing. NOTE: Only CE-IVD marked NGS-tests are applicable which cover FGFR2 fusions and rearrangements.
• Patients previously received local therapy for iCCA in form of curative surgery/ SBRT/ ablation or other local curative therapy up to 12 weeks prior to enrollment (initiation of conventional adjuvant systemic therapy without signs of PD might be permitted for bridging the time gap to achieve FGFR2-results - only after consultation with the LKP).
• Female patients who are considered as woman of childbearing potential (WOCBP) as well as male patients who are sexually active with WOCBP must use any contraceptive method with a failure rate of less than 1% per year during the treatment as well as up to 1 week after the last dose of pemigatinib. Female patients who are not of childbearing potential (i.e., who are postmenopausal or surgically sterile, see section 13.5) as well as azoospermic male patients do not require contraception. Female patients considered as WOCBP must have a negative pregnancy test within the last 7 days prior to the start of study therapy.
• ECOG performance status 0-1.