NCT05567796CompletedPhase 3
A research study to see how well CagriSema helps people with excess body weight lose weight
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c.) once-weekly in participants with overweight or obesity
Source: EU CTIS (euclinicaltrials.eu) · Last updated 19 Oct 2026
Brief summary (registry, in English)
To confirm superiority on body weight reduction of CagriSema versus placebo as adjunct to reduced-calorie diet and increased physical activity in participants with overweight or obesity.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 1101 (actual)
- First submitted
- 15 Apr 2024
- Start date
- 17 Oct 2022
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- EU CT number
- 2023-506929-11-00
- EudraCT number
- 2020-005435-75
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 1101
- 79 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of type 1 or type 2 diabetes mellitus
Lab values
- HbA1c ≥ 6.5 % (48 mmol/mol) as measured by the central laboratory at screening
Who the study is looking for
- Male or female
- Age above or equal to 18 years at the time of signing informed consent
- BMI ≥ 30.0 kg/m2 or b) BMI ≥ 27.0 kg/m2 with the presence of at least one obesity-related complication including, but not limited to hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (79)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Imelda Coordinator of this site? Confirm its status | Bonheiden | Belgium | Completed |
| CHU Helora Coordinator of this site? Confirm its status | Boussu | Belgium | Completed |
| Antwerp University Hospital Coordinator of this site? Confirm its status | Edegem | Belgium | Completed |
| Universitair Ziekenhuis Gent Coordinator of this site? Confirm its status | Gent | Belgium | Completed |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Completed |
| Cliniques Universitaires Saint-Luc Coordinator of this site? Confirm its status | Sint-Lambrechts-Woluwe | Belgium | Completed |
| Mnogoprofilna Bolnitsa Za Aktivno Lechenie Puls AD Coordinator of this site? Confirm its status | Blagoevgrad | Bulgaria | Completed |
| Asclepius Medical Center OOD Coordinator of this site? Confirm its status | Dupnitsa | Bulgaria | Completed |
| Outpatient Clinic For Individual Practice For Specialized Outpatient Medical Care Endocrinology Nt EOOD Coordinator of this site? Confirm its status | Montana | Bulgaria | Completed |
| Outpatient Clinic For Specialized Outpatient Medical Care In Endocrinology Dr Albena Dinkova EOOD Coordinator of this site? Confirm its status | Pleven | Bulgaria | Completed |
| Diagnostic And Consulting Center East Ltd. Coordinator of this site? Confirm its status | Plovdiv | Bulgaria | Completed |
| Outpatient Clinic for Specialized Outpatient Medical Care in Endocrinology and Metabolic Diseases Coordinator of this site? Confirm its status | Ruse | Bulgaria | Completed |
| Nader Yabrudi - ambulatory for specialized medical care of internal diseases and endocrinology Coordinator of this site? Confirm its status | Smolyan | Bulgaria | Completed |
| Alexandrovska University Hospital Coordinator of this site? Confirm its status | Sofia | Bulgaria | Completed |
| Diagnostichno-Konsultativen Tsentar XVIII-Sofia OOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Completed |
| Diagnostic Consultation Center XX-Sofia EOOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Completed |
| Uniteversity Muliprofile Hospital For Active Treatment Tsaritsa Yoanna-Isul EAD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Completed |
| University Specialized Hospital For Active Treatment In Endocrinology Akad. Iv. Penchev EAD Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Completed |
| Ambulatory For Individual Practice And Specialized Medical Aid Dr. Artin Magardichian Ltd. Coordinator of this site? Confirm its status | Varna | Bulgaria | Completed |
| Medical Center Berbatov Ltd. Coordinator of this site? Confirm its status | Yambol | Bulgaria | Completed |
| MVZ DiaMedicum Bad Mergentheim GmbH Coordinator of this site? Confirm its status | Bad Mergentheim | Germany | Completed |
| Zentrum fuer klinische Studien Suedbrandenburg GmbH Coordinator of this site? Confirm its status | Elsterwerda | Germany | Completed |
| InnoDiab Forschung Gmbh Coordinator of this site? Confirm its status | Essen | Germany | Completed |
| Wendisch/Dahl Hamburg Coordinator of this site? Confirm its status | Hamburg | Germany | Completed |
| Ambenet GmbH Das Ambulante Behandlungsnetz Coordinator of this site? Confirm its status | Leipzig | Germany | Completed |
| Universitaet Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Completed |
| Institut fuer Diabetesforschung Muenster GmbH Coordinator of this site? Confirm its status | Muenster | Germany | Completed |
| MZM Praxis Drs. Erlinger Coordinator of this site? Confirm its status | Stuttgart | Germany | Completed |
| Zentrum für klinische Forschung Allgäu-Oberschwaben Coordinator of this site? Confirm its status | Wangen | Germany | Completed |
| Aarhus Universitetshospital Coordinator of this site? Confirm its status | Aarhus N | Denmark | Completed |
| Esbjerg Og Grindsted Sygehus Coordinator of this site? Confirm its status | Esbjerg | Denmark | Completed |
| Gentofte Hospital Coordinator of this site? Confirm its status | Hellerup | Denmark | Completed |
| Hvidovre Hospital Coordinator of this site? Confirm its status | Hvidovre | Denmark | Completed |
| Region Sjaelland Coordinator of this site? Confirm its status | Koege | Denmark | Completed |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Completed |
| Hospital Nisa Sevilla Aljarafe Coordinator of this site? Confirm its status | Castilleja De La Cuesta | Spain | Completed |
| Area De Salud De Leon Y El Bierzo Coordinator of this site? Confirm its status | Leon | Spain | Completed |
| Hospital General Universitario Gregorio Marañón Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Completed |
| Hospital Quironsalud Infanta Luisa Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Nuevas Tecnologias En Diabetes Y En Endocrinologia S.L. Profesional Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| HUS-Yhtymae Coordinator of this site? Confirm its status | Helsinki | Finland | Completed |
| Health Step Finland Oy Coordinator of this site? Confirm its status | Kuopio | Finland | Completed |
| Oulu University Hospital Coordinator of this site? Confirm its status | Oulu | Finland | Completed |
| Turku University Hospital Coordinator of this site? Confirm its status | Turku | Finland | Completed |
| Assistance Publique Hopitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Completed |
| Hospices Civils de Lyon Coordinator of this site? Confirm its status | Pierre-Bénite | France | Completed |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Saint-Herblain | France | Completed |
| Les Hopitaux Universitaires De Strasbourg Coordinator of this site? Confirm its status | Strasbourg Cedex 2 | France | Completed |
| Centre de Recherche Clinique Portes Du Sud Coordinator of this site? Confirm its status | Vénissieux | France | Completed |
| Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico Coordinator of this site? Confirm its status | Bologna | Italy | Completed |
| Ospedale Garibaldi Coordinator of this site? Confirm its status | Catania | Italy | Completed |
| Azienda Ospedaliera Universitaria Mater Domini Coordinator of this site? Confirm its status | Catanzaro | Italy | Completed |
| Azienda Ospedale Universita Padova Coordinator of this site? Confirm its status | Padova | Italy | Completed |
| Fondazione Policlinico Universitario Campus Bio-medico In Forma A Bbreviata Fon Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Azienda Ospedaliera Policlinico Universitario Tor Vergata Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Azienda Ospedaliero-Universitaria Policlinico Umberto I Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| IRCCS Policlinico San Donato Coordinator of this site? Confirm its status | San Donato Milanese | Italy | Completed |
| Azienda Ospedaliera Universitaria Senese Coordinator of this site? Confirm its status | Siena | Italy | Completed |
| Academisch Medisch Centrum Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Completed |
| Rijnstate Ziekenhuis Stichting Coordinator of this site? Confirm its status | Arnhem | Netherlands | Completed |
| Spaarne Gasthuis Stichting Coordinator of this site? Confirm its status | Hoofddorp | Netherlands | Completed |
| Bravis Ziekenhuis Coordinator of this site? Confirm its status | Roosendaal | Netherlands | Completed |
| Albert Schweitzer Ziekenhuis Coordinator of this site? Confirm its status | Zwijndrecht | Netherlands | Completed |
| Uniwersytecki Szpital Kliniczny w Bialymstoku Coordinator of this site? Confirm its status | Bialystok | Poland | Completed |
| Gabinet Leczenia Otyłości i Chorób Dietozależnych Coordinator of this site? Confirm its status | Białystok | Poland | Completed |
| Niepubliczny Zakład Opieki Zdrowotnej Vita-Diabetica Małgorzata Buraczyk Coordinator of this site? Confirm its status | Białystok | Poland | Completed |
| Centrum Kardiometaboliczne Gierach-Med Marcin Gierach Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Completed |
| 50BIO.COM sp. z o.o., Przychodnia "Przy Szpitalu" Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Completed |
| Centrum Medyczne Plejady Magdalena Celinska Loewenhoff Michal Zolnowski sp.k. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Klinika Bellamed Coordinator of this site? Confirm its status | Elblag | Poland | Completed |
| Uniwersyteckie Centrum Kliniczne Coordinator of this site? Confirm its status | Gdansk | Poland | Completed |
| Salvia Lekston I Madej Sp. J. Coordinator of this site? Confirm its status | Katowice | Poland | Completed |
| Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j. Coordinator of this site? Confirm its status | Legnica | Poland | Completed |
| Terpa Sp. z o.o. S.K. Coordinator of this site? Confirm its status | Lublin | Poland | Completed |
| Centrum Ginekologii Poloznictwa I Leczenia Nieplodnosci Pastelova Sp z.o.o. Coordinator of this site? Confirm its status | Poznan | Poland | Completed |
| Centrum Zdrowia Metabolicznego Coordinator of this site? Confirm its status | Poznan | Poland | Completed |
| Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego CMKP Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Instytut Diabetologii.sp.z.o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
Related publications
- CagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1.Hypertension · 2026 · PMID 41328546
This page is information, not medical advice. Discuss any trial with your doctor.