NCT05571878Completed
Is Brain Insulin Resistance a Feature of the Biology of Depression in Adolescents
Is Brain Insulin Resistance a Feature of the Biology of Depression: A Pilot Multi-modality Neuroimaging Study in Adolescents
Source: ClinicalTrials.gov · Last updated 31 Mar 2026
Brief summary (registry, in English)
This study will examine if brain insulin resistance is a feature of depression in humans using magnetic resonance imaging (MRI) measures sensitive to brain insulin action. This study will examine adolescents, as depression onset commonly occurs during this age, and the impacts of cumulative medication exposure and other lifestyle-related confounds are also lower in this age group, improving our ability to understand the underlying biology.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 24 (actual)
- First submitted
- 30 Sept 2022
- Start date
- 1 Sept 2021
- Primary completion date
- 13 May 2025
- Lead sponsor
- Centre for Addiction and Mental Health
- Diseases
- Depression, Type 2 diabetes
- NCT number
- NCT05571878
What you commit to
- Study type: Interventional
- Participants enrolled: 24
- From 1 Sept 2021 to the primary completion date, 13 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Positive result on urine drug screen (participants with positive cannabis and alcohol urine drug screens may still be eligible for the study; positive drug screens for other substances will be exclusionary)
Other illness
- History of primary psychotic illness
- History of current substance use disorder (moderate to severe)
- History of kidney disease
- Allergic to exogenous insulin
Lab values
- Pre-diabetes or diabetes (fasting glucose ≥6.0 mmol/l or use of anti-diabetic drug)
- Evidence of impaired glucose tolerance on screening oral glucose tolerance test (OGTT)
- History of liver disease or AST\>2 times upper limit of normal
Other
- Use of antipsychotics or mood stabilizers
- Use of weight, lipids, or blood pressure reducing agents
- MRI contraindications
- Positive pregnancy test
Who the study is looking for
- Age 14- 18
- One of the following: Diagnosis of Major Depressive Disorder (MDD) or Persistent Depressive Disorder (PDD); or score ≥22 on the Mood and Feeling Questionnaire and confirmation of depression with the Mini International Neuropsychiatric Interview Kid (MINI Kid)
- BMI between 5-95th population percentile and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) ≤2.5 calculated using fasting blood work values (glucose and insulin)
Age in the registry: 14 years to 18 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre for Addiction and Mental Health Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.