NCT05572736Completed
Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure
Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure (PhysioSync-HF)
Source: ClinicalTrials.gov · Last updated 8 Jun 2025
Brief summary (registry, in English)
The purpose of this study is to evaluate the efficacy and safety of conduction system pacing versus biventricular pacing in patients with chronic heart failure with reduced ejection fraction and left bundle branch block.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 179 (actual)
- First submitted
- 2 Sept 2022
- Start date
- Nov 2022
- Primary completion date
- Jan 2025
- Lead sponsor
- Hospital Moinhos de Vento
- Diseases
- Heart failure
- NCT number
- NCT05572736
What you commit to
- Study type: Interventional
- Participants enrolled: 179
- From Nov 2022 to the primary completion date, Jan 2025
- 14 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Plan to implant an implantable cardioverter defibrillator (ICD), with or without resynchronization therapy (CRT-D)
Other illness
- Life expectancy \<12 months due to any disease
- Dementia or advanced cerebrovascular disease
- Enrollment in other clinical trials involving cardiac pacing
Other
- NYHA class IV
- Pregnancy or pre-menopausal women who do not use regular contraceptive methods
- Patients unable to understand and sign the consent for participation
Who the study is looking for
- Male or female, age ≥18 years
- Established diagnosis of symptomatic heart failure (New York Heart Association class II-III)
- Left ventricular ejection fraction ≤35% in prior 3 months
- Left bundle branch block (QRS ≥130 ms)
- Clinical indication for cardiac resynchronization therapy
- Patients should be clinically stable
- Patients should receive background standard of care for heart failure with reduced ejection fraction, with the maximum tolerated doses of ACE inhibitor or ARB or ARNI, beta-blocker, and mineralocorticoid receptor antagonist
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Geral Universitário de Cuiabá Coordinator of this site? Confirm its status | Cuiabá | Brazil | Unknown status |
| SOS Cardio Coordinator of this site? Confirm its status | Florianópolis | Brazil | Unknown status |
| Fundação Hospital do Coração Francisca Mendes Coordinator of this site? Confirm its status | Manaus | Brazil | Unknown status |
| Hospital Moinhos de Vento Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Hospital Mae de Deus Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Hospital de Clinicas de Porto Alegre Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Unknown status |
| Instituto de Medicina Integral Professor Fernando Figueira Coordinator of this site? Confirm its status | Recife | Brazil | Unknown status |
| Instituto Nacional de Cardiologia Coordinator of this site? Confirm its status | Rio de Janeiro | Brazil | Unknown status |
| Hospital Ana Nery Coordinator of this site? Confirm its status | Salvador | Brazil | Unknown status |
| Instituto de Cardiologia de Santa Catarina Coordinator of this site? Confirm its status | São José | Brazil | Unknown status |
| Beneficência Portuguesa Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Hospital Alemão Oswaldo Cruz Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
| Hospital Universitário da Universidade Federal do Piauí Coordinator of this site? Confirm its status | Teresina | Brazil | Unknown status |
| Hospital Universitário Cassiano Antônio de Moraes Coordinator of this site? Confirm its status | Vitória | Brazil | Unknown status |
Related publications
- Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial.JAMA Cardiol · 2026 · PMID 41811324
- Conduction System Pacing vs Biventricular Pacing in Chronic Heart Failure: Protocol for the Economic Analysis of the PhysioSync-HF Trial.Arq Bras Cardiol · 2025 · PMID 41779515
This page is information, not medical advice. Discuss any trial with your doctor.