NCT05574634Recruiting
The Role of the Locus Coeruleus in Age-related Distractibility
Losing Specificity: the Role of the Locus Coeruleus in Age-related Distractibility
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 13 Sept 2022
- Start date
- 11 Apr 2023
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Virginia Polytechnic Institute and State University
- Diseases
- Alzheimer disease
- NCT number
- NCT05574634
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 11 Apr 2023 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion:
- Healthy adult participants
- No younger than 18 and no older than 75 yrs of age
- Ability to provide written informed consent
- Exclusion:
- History of surgery involving metal implants
- Possible metal fragments in the eyes
- Pacemaker
- A history of claustrophobia
- Braces
- Weighing over 250 pounds
- Pregnant or possibility of being pregnant.
- Severe medical or psychiatric conditions (e.g., blind or deaf, head trauma)
- Learning disabilities or developmental disabilities
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Virginia Polytechnic Institute and State University Coordinator of this site? Confirm its status | Blacksburg | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.