NCT05575167Active, not recruiting
Single or Repeat Zoledronate Versus Alendronate Following Denosumab (EUROpean Denosumab Effects Consolidation Study)
The Effectiveness of Single or Repeat Zoledronate Infusion Versus Oral Alendronate in Consolidating the Bone Accrual Achieved With Denosumab: a Study Organised by the European Calcified Tissue Society
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
A 24-month prospective, open-label, randomized, multicenter, multinational, non-inferiority pragmatic clinical trial evaluating zoledronate single or double infusion versus oral alendronate following denosumab
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 122 (actual)
- First submitted
- 7 Oct 2022
- Start date
- 28 Nov 2023
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- 424 General Military Hospital
- Diseases
- Osteoporosis
- NCT number
- NCT05575167
What you commit to
- Study type: Observational
- Participants enrolled: 122
- From 28 Nov 2023 to the primary completion date, 31 Jul 2027
- 9 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of medications other than bisphosphonates or SERMS affecting bone metabolism during the last 12 months before entering the study
Other illness
- a bone disease other than postmenopausal osteoporosis
- liver failure
- any type of cancer
- uncontrolled endocrine diseases
Lab values
- creatinine clearance \<60 mL/min/1.73 m2
- serum 25-hydroxy vitamin D (25-OHD) concentrations lower than 20 ng/mL (50 nmol/L)
Who the study is looking for
- Postmenopausal women treated with denosumab for 3 or more years who will reach osteopenia
Age in the registry: 50 years to 85 years · Sex: Female · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Univ. Lille, CHU Lille Coordinator of this site? Confirm its status | Lille | France | Unknown status |
| 251 Hellenic Airforce and VA General Hospital Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| KAT General Hospital Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| 424 General Military Hospital Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Campus Bio-Medico University Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| Department of Medicine, Surgery and Neurosciences, University of Siena Coordinator of this site? Confirm its status | Siena | Italy | Unknown status |
| University-Hospital S. Maria della Misericordia Coordinator of this site? Confirm its status | Udine | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.