NCT05577143Recruiting
Blood Screening for Adult Colorectal Cancer
Evaluation of the Discriminatory Role of Blood TFPI-1 and TFPI-2 in Adult Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
Multicenter, inter-regional, case-control study with the primary objective of evaluating the discriminative power of the blood biomarker TFPI-1 to separate patients with histologically proven CRC from an asymptomatic control population between 50 and 75 years of age with normal colonoscopy.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 303 (estimated)
- First submitted
- 10 Oct 2022
- Start date
- 23 Mar 2023
- Primary completion date
- Mar 2027
- Lead sponsor
- University Hospital, Lille
- Diseases
- Colorectal cancer
- NCT number
- NCT05577143
What you commit to
- Study type: Observational
- Planned participants: 303
- From 23 Mar 2023 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Endoscopic polypectomy without prior histological confirmation.
Other illness
- All clinical situations outside of CRC that could increase TFPI-1 or 2 blood levels: acute coronary syndrome (unstable angina, acute myocardial infarction), severe sepsis, decompensated cirrhosis, pregnancy, chronic inflammatory bowel disease (Crohn's or ulcerative colitis), colitis or radiation rectitis.
Age
- Persons of full age under legal protection or unable to express their consent
Other
- Emergency (occlusion or peritonitis)
- Minor patients.
- Persons not affiliated to a social security system or beneficiaries of such a system.
- Pregnant women, women in labor or nursing mothers.
Who the study is looking for
- Patients with suspected colorectal cancer for which colonoscopy is indicated.
- Patients between 50 and 75 years old, asymptomatic from the digestive point of view (for example referred for colonoscopy as part of a pre-operative check-up of an inguinal hernia or 3 months after an episode of complicated sigmoiditis), for whom a follow-up colonoscopy is indicated.
- Note.
- If the post-inclusion colonoscopy is normal, no biopsy will be performed and patients will be assigned to the control group.
- If the colonoscopy performed after inclusion is abnormal (presence of at least one mucosal lesion), patients will be assigned to the "colorectal cancer" group or to the "polyps" group depending on the results of the anatomopathological analysis of the lesion(s)
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital HURIEZ - Chirurgie digestive et transplantation Coordinator of this site? Confirm its status | Lille | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.