NCT05577247Recruiting
Belief Updating in Treatment Resistant Depression
How the Brain Encodes Beliefs: A Functional Magnetic Resonance Imaging Study of the Belief Updating in Treatment Resistant Depression.
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Major depressive disorder (MDD) is characterized by a cognitive triad of negative beliefs about oneself, the future and the world. For example, depressed patients hold persistently negative expectations about the future, despite contradictory evidence, and these strong negative beliefs are thought to play an important role in the maintenance of depressive symptoms and potentially in treatment resistance. Indeed, one out of three patients with major depressive disorder does not respond to conventional, monoaminergic treatments, which has led to the concept of treatment resistant depression (TRD). It is unknown how the brain encodes the strong negative beliefs that are insensitive to positive disconfirming information in TRD patients, and how these neural underpinnings of maladaptive belief updating are altered by antidepressant treatment. The principal objective of this study is to gain insight into the brain mechanisms of belief updating about the future in TRD patients before and after starting ketamine treatment. The results of this study are expected to provide a better understanding of the neurocognitive mechanisms of belief-updating in depressed patients, and how these mechanisms contribute to clinical improvement following ketamine antidepressant treatment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 20 Sept 2022
- Start date
- 13 May 2024
- Primary completion date
- 13 Dec 2026
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Depression
- NCT number
- NCT05577247
What you commit to
- Study type: Observational
- Planned participants: 60
- From 13 May 2024 to the primary completion date, 13 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antidepressant treatment involving dopaminergic agonists, and Monoamine oxidase inhibitors (MAOI)
Other illness
- Mental disorder other than MDD: personality disorder type borderline, schizophrenia
- Neurological comorbidities : epilepsy, brain tumor, non-corrected visual and/or auditory deficit
- Criteria associated with contraindications/procedures/interventions added by the research:
- o Contra-indications for an MRI exam (metallic implant, pacemaker, artificial heart valve, brain vascular malformation, aneurysm clips, exposed by metallic fragments, artificial implants, peripheral or neuronal stimulator, insulin pump, intravenous catheter, epilepsy, metallic contraceptive device, claustrophobia, unwillingness to be informed in case of abnormal MRI (with a significant medical anomaly))
- Criteria relating to vulnerable populations:
Other
- Criteria relating to associated pathologies carrying specific risks:
- Inability to understand the task instructions and to perform the behavioral task
- Mini Mental Score (MMS) ≤ 25
- Pregnancy
- Patient on AME (state medical aid)
- Patient under guardianship, curators or legal protection
Who the study is looking for
- Demographic criteria:
- Age: 18 to 70 years
- Male et female
- Diagnostic criteria, severity and clinical course:
- Major depressive disorder (MDD) according to the DSM5 criteria
- MADRS≥20,
- Treatment resistant depression (TRD) defined by failure to respond to at least two trials of different antidepressant treatments
- affiliation of a social security regime
- Treatments/strategies/procedures:
- o At the start of new antidepressant treatment involving glutamate receptor modulators.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gh Pitie Salpetriere Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.