NCT05577481CompletedPhase 2
Neuronavigation Guided iTBS With Personalized Target for Depression
Research on the Efficacy and Brain Network Mechanism of Personalized Targeting Intermittent Theta Burst Stimulation (iTBS) Based on Functional Magnetic Resonance Imaging for the Treatment of Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 27 Apr 2026
Brief summary (registry, in English)
The study will compare the efficacy of intermittent Theta Burst Stimulation (iTBS) with DLPFC-pgACC personalized target for major depressive disorder (MDD) and explore possible brain network mechanisms. The stimulated targets will be located by magnetic resonance imaging (MRI) based on functional MRI based on functional connectivity respectively. This study aims to identify that functional connectivity targeted iTBS protocols on DLPFC-pgACC personalized target have a better antidepressant efficacy compared the sham group and certify that pgACC is an effective potential effector target.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 68 (actual)
- First submitted
- 25 Sept 2022
- Start date
- 10 Jul 2023
- Primary completion date
- 30 Jan 2025
- Lead sponsor
- Xijing Hospital
- Diseases
- Depression
- NCT number
- NCT05577481
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 68
- From 10 Jul 2023 to the primary completion date, 30 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- psychotic symptoms, alcohol or drug abuse
Other illness
- any other current or past psychiatric axis-I or axis-II disorders
- severe physical illnesses
- A history of neurological disorders including seizure, cerebral trauma
Other
- MRI evidence of structural brain abnormalities
- Contraindications to MRI and rTMS
- Acute suicide
- Female that is pregnant or breastfeeding
Who the study is looking for
- 18 to 60 years old
- Meet the criteria of the Diagnostic and Statistical Manual of Mental Disorder- V of MDD, single or recurrent
- Meet the threshold on the total HAMD17 score of \>17 at both screening and baseline visits
- Able to provide informed consent
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| XijingH Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.