NCT05579470Recruiting
Expanding Medication-Assisted Therapies in Central Asia
Source: ClinicalTrials.gov · Last updated 14 Oct 2026
Brief summary (registry, in English)
Central Asia (CA) represents the most rapidly growing HIV epidemic region worldwide, concentrated in people who inject drugs (PWID) and their sexual partners, and scaling up opioid agonist therapies (OAT) in this region is the most cost-effective strategy to prevent new HIV infections, and more effective when combined with antiretroviral therapy (ART). The investigators propose to use the Network for the Improvement of Addiction Treatment (NIATx) implementation strategy to scale-up OAT in three diverse Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan) and guided by the Exploration-Planning-Implementation-Sustainment (EPIS) framework. Understanding the trajectories of implementation and scale-up in this context may emerge through creating communities of practice, especially when cohesion and competence evolves, and may guide other healthcare delivery challenges in the region (e.g., HIV, TB); as well as build important regional expertise and understanding implementation trajectories should help support OAT program sustainability.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 900 (estimated)
- First submitted
- 10 Oct 2022
- Start date
- 7 Aug 2023
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Yale University
- NCT number
- NCT05579470
What you commit to
- Study type: Interventional
- Planned participants: 900
- From 7 Aug 2023 to the primary completion date, 31 Dec 2027
- 4 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Not willing to provide consent
Who the study is looking for
- Aim 1: The inclusion criteria for Aim 1 Consists of:
- Quantitative surveys for PWID
- 18 years or older
- Meeting DSM-V criteria for opioid dependence
- Be either treatment naïve and seeking OAT or be on OAT for \< 90 days
- Organizational Assessments for OAT Delivery Staff
- 18 years or older
- Currently working as an OAT delivery professional at an OAT delivery site
- Focus Groups (PWID on OAT)
- 18 years or older
- Meeting DSM-V criteria for opioid dependence
- Be either treatment naïve and seeking OAT or be on OAT for \< 90 days
- Focus Groups (PWID not on OAT)
- 18 years or older
- Meeting Diagnostic and Statistical Manual of Mental Disorders(DSM)-V criteria for opioid dependence
- Be OAT naïve (defined as never having been on OAT or having not received treatment for \> 1 year)
- Focus Groups (OAT delivery staff)
- 18 years or older
- Currently working as an OAT delivery professional at an OAT delivery site
- Aim 2: The inclusion criteria for Aim 2 consists of:
- 18 years or older
- Currently assigned as a Chief Narcologist for an Oblast
- Aim 3: The inclusion criteria for Aim 3 consists of:
- 18 years or older
- Authorized as a professional to work at an OAT delivery site
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Den Sooluk Nuru Coordinator of this site? Confirm its status | Bishkek | Kyrgyzstan | Recruiting |
| Columbia University Global Health Research Center of Central Asia Coordinator of this site? Confirm its status | Almaty | Kazakhstan | Recruiting |
| Institute for International Health and Education Coordinator of this site? Confirm its status | Dushanbe | Tajikistan | Recruiting |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.