NCT05580666RecruitingPhase 3
Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
Reducing Mortality in Adults With Advanced HIV Disease, a Double Blinded Randomized Trial
Source: ClinicalTrials.gov · Last updated 3 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 8000 (estimated)
- First submitted
- 11 Oct 2022
- Start date
- 8 May 2023
- Primary completion date
- 30 Nov 2028
- Lead sponsor
- Population Health Research Institute
- Diseases
- HIV
- NCT number
- NCT05580666
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 8000
- From 8 May 2023 to the primary completion date, 30 Nov 2028
- 52 sites in 11 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Off-label azithromycin prophylaxis or requirement for prolonged (\> 7 days) azithromycin (or macrolide) therapy
Other illness
- Severe illness requiring immediate or continued hospitalization (this will be in the judgment of site investigators)
Lab values
- Contraindications to azithromycin:
- Hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic; or
- Personal or family history of QT-prolongation
Who the study is looking for
- Age ≥ 18 years
- Documented HIV infection
- CD4 count criteria:
- CD4 count ≤ 100 cells/mm3 within past 4 weeks; or
- Documented CD4 nadir ≤ 100 cells/mm3 and complete interruption of ART for ≥ 6 months; or
- Documented CD4 count ≤ 100 cells/mm3 if ART-naive
- Ability to initiate or re-initiate ART, or switch to an effective ART regimen if failing current therapy, within 4 weeks of enrolment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (52)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Unité de Soins Ambulatoires et de conseils (USAC) Coordinator of this site? Confirm its status | Abidjan | Côte d’Ivoire | Not yet recruiting |
| Centre médical de suivi des donneurs de sang (CMSDS) Coordinator of this site? Confirm its status | Abidjan | Côte d’Ivoire | Not yet recruiting |
| Centre Intégré de Recherches Biocliniques d'Abidjan (CIRBA) Coordinator of this site? Confirm its status | Abidjan | Côte d’Ivoire | Not yet recruiting |
| Adama Hospital Medical College Coordinator of this site? Confirm its status | Ādama | Ethiopia | Recruiting |
| Asella Referral and Teaching Hospital Coordinator of this site? Confirm its status | Āsela | Ethiopia | Recruiting |
| Jimma University Hospital Coordinator of this site? Confirm its status | Jimma | Ethiopia | Recruiting |
| Tigray health research institute (THRI) Coordinator of this site? Confirm its status | Mek'ele | Ethiopia | Not yet recruiting |
| Kumasi South Hospital Coordinator of this site? Confirm its status | Kumasi | Ghana | Recruiting |
| Komfo Anokye Teaching Hospital Coordinator of this site? Confirm its status | Kumasi | Ghana | Not yet recruiting |
| Suntreso Government Hospital Coordinator of this site? Confirm its status | Kumasi | Ghana | Recruiting |
| Lilongwe Medical Relief Fund/UNC Project Coordinator of this site? Confirm its status | Lilongwe | Malawi | Not yet recruiting |
| Faculty of Medicine, Eduardo Mondlane University Coordinator of this site? Confirm its status | Maputo | Mozambique | Not yet recruiting |
| University of Abuja Teaching Hospital Coordinator of this site? Confirm its status | Abuja | Nigeria | Not yet recruiting |
| University of Calabar Teaching Hospital Coordinator of this site? Confirm its status | Calabar | Nigeria | Not yet recruiting |
| University of Nigeria Teaching Hospital Coordinator of this site? Confirm its status | Enugu | Nigeria | Recruiting |
| University College Hospital Coordinator of this site? Confirm its status | Ibadan | Nigeria | Recruiting |
| Jos University Teaching Hospital Coordinator of this site? Confirm its status | Jos | Nigeria | Active, not recruiting |
| Aminu Kano Teaching Hospital Coordinator of this site? Confirm its status | Kano | Nigeria | Not yet recruiting |
| Lagos University Teaching Hospital Coordinator of this site? Confirm its status | Lago | Nigeria | Recruiting |
| Usmanu Danfodiyo University Teaching Hos Coordinator of this site? Confirm its status | Sokoto | Nigeria | Active, not recruiting |
| Federal Medical Center Coordinator of this site? Confirm its status | Umuahia | Nigeria | Not yet recruiting |
| University of Uyo Teaching Hospital Coordinator of this site? Confirm its status | Uyo | Nigeria | Active, not recruiting |
| Niger Delta University Teaching Hospital Coordinator of this site? Confirm its status | Yenagoa | Nigeria | Not yet recruiting |
| Centre Hospitalier Universitaire de Kigali (CHUK) Coordinator of this site? Confirm its status | Kigali | Rwanda | Not yet recruiting |
| 34 Military Hospital Coordinator of this site? Confirm its status | Freetown | Sierra Leone | Recruiting |
| College of Medicine and Allied Health Sciences, University of Sierra Leone Coordinator of this site? Confirm its status | Freetown | Sierra Leone | Recruiting |
| Kenema Regional Hospital Coordinator of this site? Confirm its status | Kenema | Sierra Leone | Recruiting |
| Koidu Government Hospital Coordinator of this site? Confirm its status | Koidu | Sierra Leone | Recruiting |
| Makeni Regional Hospital Coordinator of this site? Confirm its status | Makeni | Sierra Leone | Recruiting |
| SICRA Kampala Coordinator of this site? Confirm its status | Kampala | Uganda | Recruiting |
| MUJHU Coordinator of this site? Confirm its status | Kampala | Uganda | Recruiting |
| SICRA Lira Coordinator of this site? Confirm its status | Lira | Uganda | Recruiting |
| Mbarara Regional Referral Hospital Coordinator of this site? Confirm its status | Mbarara | Uganda | Recruiting |
| Ubuntu Clinic, Site B, Khayelitsha, Wellcome Centre Coordinator of this site? Confirm its status | Cape Town | South Africa | Recruiting |
| New Somerset Hospital Coordinator of this site? Confirm its status | Cape Town | South Africa | Recruiting |
| Groote Schuur Hospital -New main building, Infectious Disease Clinic G26 Coordinator of this site? Confirm its status | Cape Town | South Africa | Not yet recruiting |
| Desmond Tutu Health Foundation Coordinator of this site? Confirm its status | Cape Town | South Africa | Not yet recruiting |
| Africa Health Research Institute (AHRI)- Nkundusi Clinic Coordinator of this site? Confirm its status | Hlabisa | South Africa | Not yet recruiting |
| Africa Health Research Institute (AHRI)- Hluhluwe Clinic Coordinator of this site? Confirm its status | Hluhluwe | South Africa | Not yet recruiting |
| Wits Health Consortium (Pty) Ltd Coordinator of this site? Confirm its status | Johannesburg | South Africa | Recruiting |
| The Aurum Institute Coordinator of this site? Confirm its status | Klerksdorp | South Africa | Not yet recruiting |
| Africa Health Research Institute (AHRI)- Mtubatuba Clinic Coordinator of this site? Confirm its status | Mtubatuba | South Africa | Not yet recruiting |
| Africa Health Research Institute (AHRI)- KwaMsane Clinic Coordinator of this site? Confirm its status | Mtubatuba | South Africa | Not yet recruiting |
| Africa Health Research Institute (AHRI)- Mpukunyoni Clinic Coordinator of this site? Confirm its status | Mtubatuba | South Africa | Not yet recruiting |
| Africa Health Research Institute (AHRI)- Somkhele Clinic Coordinator of this site? Confirm its status | Mtubatuba | South Africa | Not yet recruiting |
| Livingstone hospital Coordinator of this site? Confirm its status | Port Elizabeth | South Africa | Recruiting |
| Steve Biko Academic Hospital, University of Pretoria Coordinator of this site? Confirm its status | Pretoria | South Africa | Recruiting |
| Right to Care NPC, Esizayo Division Coordinator of this site? Confirm its status | Randburg | South Africa | Completed |
| The Aurum Institute Coordinator of this site? Confirm its status | Rustenburg | South Africa | Not yet recruiting |
| The Center for Infectious Disease Research in Zambia (CIDRZ)- George Clinical Research Site Coordinator of this site? Confirm its status | Lusaka | Zambia | Not yet recruiting |
| The Center for Infectious Disease Research in Zambia (CIDRZ)-Chawama Clinical Research Site (CRS) Coordinator of this site? Confirm its status | Lusaka | Zambia | Not yet recruiting |
| The Center for Infectious Disease Research in Zambia (CIDRZ)- Matero Clinical Research Site Coordinator of this site? Confirm its status | Lusaka | Zambia | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.