NCT05585411Recruiting
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 5 Jan 2026
Brief summary (registry, in English)
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period. The purpose of this study to compare the clinical outcomes of Left Bundle Branch Area Pacing (LBBAP) compared to Right Ventricular Pacing (RVP) in bradyarrhythmia patients who require high burden of ventricular pacing (\>40%).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 450 (estimated)
- First submitted
- 14 Oct 2022
- Start date
- 1 Nov 2022
- Primary completion date
- 1 Nov 2026
- Lead sponsor
- Yonsei University
- Diseases
- Heart failure
- NCT number
- NCT05585411
What you commit to
- Study type: Interventional
- Planned participants: 450
- From 1 Nov 2022 to the primary completion date, 1 Nov 2026
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior myocardial infarction including ventricular septum
- Prior Heart transplant surgery
Other illness
- History of prosthetic valve surgery on tricuspid valve
- Life expectancy \< 12 months due to any condition
Other
- Incapacitated or unable to read or write
- Patient who is an indication of ICD or CRT
- Unavailable for at least 24 months of follow-up visits
- Pregnant or breastfeeding at the time of signing consent
- Persistent Left Superior Vena Cava (PLSVC)
Who the study is looking for
- At least 19 years old and willing and capable to give informed consent
- Patients who is willing and able to comply with the prescribed follow-up tests and schedule of evaluations.
- 3 Scheduled to receive a pacemaker implant 4. Substantial percentage of V pacing rate (\>40%) is anticipated
Age in the registry: 19 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bucheon Sejong Hospital Coordinator of this site? Confirm its status | Bucheon-si | South Korea | Recruiting |
| Gyeongsang National University Changwon hospital Coordinator of this site? Confirm its status | Changwon | South Korea | Recruiting |
| Chungbuk National University Hospital Coordinator of this site? Confirm its status | Chungju | South Korea | Recruiting |
| Yonsei University Health System, Severance Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Not yet recruiting |
| Kyunghee university hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Seoul saint Mary's Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Asan Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.