NCT05585502Completed
Impact of Muscle and Tendon Dysfunction in People With Type 2 Diabetes Mellitus
Impact of Muscle and Tendon Dysfunction on the Mechanics of Muscle Contraction and Locomotion Capacity in People With Type 2 Diabetes Mellitus, and Efficacy of a Passive Stretching Training Program to Counteract These Alterations
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
Diabetes is a chronic-degenerative metabolic disorder that has reached pandemic proportions mainly because of the increasing incidence and prevalence of type 2 diabetes mellitus (T2D). Diabetes hurts cardiovascular function due to chronic hyperinsulinemia and hyperglycemia, along with increased advanced glycation end products (AGEs) causing nonenzymatic glycation of soft tissues, including muscle and tendon, and leading to an increase in muscle and tendon stiffness. In turn, the stiffening of the muscle-tendon complex reduces its capability to change in shape, affecting its potential for modulating the mechanical request during contraction (and locomotion), also increasing the metabolic demands during walking. The present, multi-disciplinary, project combines several experimental methods and procedures to investigate the impact of muscle and tendon alterations on the mechanics of muscle contraction and locomotion capacity in T2D patients. In this project, we also propose a new training approach (minute oscillation stretching) to counteract these possible alterations (e.g. to decrease muscle and tendon stiffness).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 46 (actual)
- First submitted
- 6 Oct 2022
- Start date
- 10 Dec 2022
- Primary completion date
- 30 Oct 2023
- Lead sponsor
- Universita di Verona
- Diseases
- Type 2 diabetes
- NCT number
- NCT05585502
What you commit to
- Study type: Interventional
- Participants enrolled: 46
- From 10 Dec 2022 to the primary completion date, 30 Oct 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- previous foot/knee surgery
- previous Achille tendon rupture
- previous Charcot foot
- insulin therapy
Other illness
- arterial insufficiency
Other
- neuropathy of nondiabetic origin
- severe neuropathy
- foot ulcers
- arthritis of the ankle/foot
- cardiovascular and respiratory deficits that would impede the performance of the locomotion test
Who the study is looking for
- body mass index between 23 and 30 kg/m2
- moderate level of physical activity in the everyday life (assessed by means of the International Physical Activity Questionnaires, IPAQ)
Age in the registry: 50 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sezione di Scienze Motorie Coordinator of this site? Confirm its status | Verona | Italy | Unknown status |
Related publications
- Impact of controlled type 2 diabetes on muscle-tendon mechanics.Acta Diabetol · 2026 · PMID 42089958
This page is information, not medical advice. Discuss any trial with your doctor.