NCT05595954Recruiting
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery (PRECISION)
Source: ClinicalTrials.gov · Last updated 30 Jun 2026
Brief summary (registry, in English)
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 18 Oct 2022
- Start date
- 23 Jan 2023
- Primary completion date
- 4 May 2026
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Stroke
- NCT number
- NCT05595954
What you commit to
- Study type: Observational
- Planned participants: 500
- From 23 Jan 2023 to the primary completion date, 4 May 2026
- 4 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Surgery requiring moderate (28-31.9ºC) or deep (\<28ºC) hypothermic circulatory arrest;
- Urgent (within 24 hours) and emergency surgery;
Other illness
- Heart and/or lung transplantation;
- Inability to give consent.
- Participants who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded.
Other
- Inability to follow procedures or insufficient knowledge in English, German or French;
Who the study is looking for
- Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass.
Age in the registry: 65 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Completed |
| Inselspital, Bern University Hospital Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Cambridge University Hospitals and Brain Physics Lab Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Completed |
| Royal Papworth Hospital, Department of Anaesthesia and Intensive Care Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Completed |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.