NCT05598008Completed
Effects of Glucagon-like-Peptide-1 Analogues on Sexuality
The Desire PLUS Study - Effects of Glucagon-like-Peptide-1 Analogues on Sexuality: a Prospective Open-label Study
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
This study is to investigate the effects of GLP-1 analogues (combined with lifestyle interventions in comparison to lifestyle interventions only) on sexual desire, mood, quality of life, the reproductive axis, retinal vessel diameters, physical fitness (and semen, for men only) in overweight or obese men and women.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 85 (actual)
- First submitted
- 19 Oct 2022
- Start date
- 25 Nov 2022
- Primary completion date
- 24 Oct 2025
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Obesity
- NCT number
- NCT05598008
What you commit to
- Study type: Observational
- Participants enrolled: 85
- From 25 Nov 2022 to the primary completion date, 24 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous use of GLP-1 analogues during last 2 months.
- Current illicit drug abuse
Lab values
- Diabetes mellitus, HbA1c ≥ 6,5 %
Other
- Exogenous testosterone substitution
- Pregnancy
Who the study is looking for
- BMI ≥ 27 kg/m2
- Willingness to lose weight by lifestyle changes only or by lifestyle changes plus GLP-1 analogue treatment as agreed in a routine clinical appointment
- Active sex life (sex with partner or masturbation ≥2x/month)
- Eugonadism:
- Men: morning total testosterone ≥12mmol/l or free testosterone ≥ 0.198 nmol/l if\< 50 years old and ≥ 0.163 if \> 50 years old
- Women: no primary or secondary amenorrhea (inclusive menopause) \*Secondary amenorrhea is defined as "absence of menses for more than three months in women who previously had regular menstrual cycles or six months in women who had irregular menses".
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Basel, Endocrinology, Diabetes and Metabolism Coordinator of this site? Confirm its status | Basel | Switzerland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.