NCT05600621Active, not recruiting
Suubi+Adherence4Youth
Suubi+Adherence4Youth: Optimizing the Suubi Intervention for Adherence to HIV Treatment for Youth Living With HIV in Uganda
Source: ClinicalTrials.gov · Last updated 13 Jan 2026
Brief summary (registry, in English)
The study will test four economic empowerment intervention components to identify the combination that best enhance viral suppression. The study design is a 2-to-the 4 factorial experiment. The 2 represents the level of each component:0 (receive) or (don't receive) four components: 1) Financial Literacy Training (FLT); 2) Incentivized Matched Youth Savings Accounts (YSA) with income-generating activities (IGAs); 3) A manualized intervention for ART adherence and stigma reduction (Suubi Cartoon); and 4) Engagement with HIV treatment-experienced role models who share their lived experiences of HIV. Guided by the MOST framework, the study will test each of the four components' performance and their combinations on the primary outcome, viral suppression. Resulting in 16 unique conditions representing all possible combinations of the 4 components. The study will randomize at the level of health clinics (N=48). Clinics will be randomized to provide one of the 16 conditions, with 12 ALHIV (aged 11-17 years) enrolled per clinic, yielding main effects and interaction effects for the 4 components on sustained viral suppression. Sustained viral suppression is defined as an undetectable viral load on all 12-, 24- and 36-month follow-up assessments.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 576 (actual)
- First submitted
- 5 Oct 2022
- Start date
- 26 Jun 2023
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- Washington University School of Medicine
- Diseases
- HIV
- NCT number
- NCT05600621
What you commit to
- Study type: Interventional
- Participants enrolled: 576
- From 26 Jun 2023 to the primary completion date, 31 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Includes an inability to understand study procedures and participant rights as assessed during informed consent/assent process with the adolescent or parent.
- If the adolescent or adult caregiver presents with emergency needs (e.g., hospitalization), needed care will be secured, rather than study participation
Who the study is looking for
- Adolescent:
- living with HIV (confirmed by medical report and aware of status)
- living within a family
- being 11-17 years of age (at enrollment)
- prescribed ART
- enrolled in ART care at one of the 48 health clinics in the study districts.
- Health clinics would be eligible if they:
- have existing procedures tailored to adolescent adherence (including adolescent-specific clinic days and peer counselling)
- Accredited by the Uganda Ministry of Health as a provider of ART within the study districts.
Age in the registry: 11 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| International Center for Child Health and Development Coordinator of this site? Confirm its status | Masaka | Uganda | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.