NCT05601817Active, not recruiting
Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
This research project is relevant to public health because both heart failure (HF) and mild cognitive impairment (e.g., trouble remembering and concentrating beyond normal aging) are highly prevalent among older adults in the United States. Despite advances in health care, there are no effective interventions for treating cognitive impairment in HF, which if left untreated, leads to suboptimal health, quality of life, and shorter survival. Therefore, the investigators propose to test the effect of a dual-component intervention comprised of a virtual reality-based cognitive restoration intervention and computerized cognitive training on cognitive function and overall health among 172 older adults with HF who experience mild cognitive impairment.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 172 (estimated)
- First submitted
- 24 Oct 2022
- Start date
- 3 Apr 2023
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Indiana University
- Diseases
- Heart failure
- NCT number
- NCT05601817
What you commit to
- Study type: Interventional
- Planned participants: 172
- From 3 Apr 2023 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- major neurological disorder (e.g., previously diagnosed dementia, Parkinson's disease, epilepsy, multiple sclerosis);
Other illness
- major psychiatric disease (e.g., schizophrenia, bipolar disorder);
- life-threatening unstable illness other than HF (e.g., end-stage cancer); and
- users of regular computerized cognitive training or participants in cognitive training trials in the past year.
- Second, we will enroll patients only if they have MCI or normal cognition by not meeting criteria for dementia.
Other
- pre-HF (Stages A and B) or advanced HF (Stage D);
- vision or hearing problems that can interfere with cognitive testing;
Who the study is looking for
- ≥ 55 years;
- chronic HF Stage C validated from echocardiography or comparable measure or B-type natriuretic peptide (BNP) level \> 400 pg/ml \[or equivalent NT-proBNP\] in past 3 years;
- ability to communicate in English;
- capacity to consent according to the Indiana University Institutional Review Board policies, or lacks capacity to consent but has the ability to provide assent from someone who can serve as LAR; and
- Subjectively reported cognitive concern assessed by the question, "Do you have any trouble with your memory or thinking?".
Criteria the registry did not label
- We will use a two-step process to screen and enroll the patients. First, we will screen potentially eligible patients from the Indiana University Health systems using these eligibility criteria.
Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Indiana University Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.