NCT05604989CompletedPhase 3
Associations Between the Oral and Intestinal Microbiome and Neovascular Age-related Macular Degeneration
Associations Between the Oral and Intestinal Microbiome and Neovascular Age-related Macular Degeneration and the Investigation on the Effect of Oral Probiotics as a Treatment - A Pilot Study
Source: ClinicalTrials.gov · Last updated 16 May 2025
Brief summary (registry, in English)
A pilot study for Associations between the oral and intestinal microbiome and neovascular age-related macular degeneration and the investigation on the effect of oral probiotics as a treatment The investigators recruit the neovascular AMD patients and control patients. 1. 15 neovascular AMD patients with anti-VEGF treatment and oral probiotics supplement 2. 15 neovascular AMD patients with anti-VEGF treatment and no oral probiotics supplement 3. 15 control patients and no oral probiotics supplement The investigators will collect stool, blood, and saliva sample at the baseline and 6 months, and analyze the oral and intestinal microbiome changes.
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 45 (actual)
- First submitted
- 17 Oct 2022
- Start date
- 1 Jan 2023
- Primary completion date
- 31 Aug 2024
- Lead sponsor
- Seoul National University Bundang Hospital
- Diseases
- Macular degeneration
- NCT number
- NCT05604989
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 45
- From 1 Jan 2023 to the primary completion date, 31 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous oral antibiotic treatment before 1 week at the baseline enroll
- Previous oral probiotics supplement
- Previous ophthalmic retinal diseases except neovascular AMD
Other illness
- Past surgical history involving intestinal diseases
Other
- Obese (BMI \> 30)
Who the study is looking for
- Normal BMI patients
- Diagnosed as neovascular AMD (experimental \& sham group)
- Normal patients (control group)
Age in the registry: 40 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Seoul National University Bundang Hospital Coordinator of this site? Confirm its status | Seongnam-si | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.