Study of a Comprehensive Intelligent Hypertension managEment SyStem

Prior treatment

• Intolerance to at least two classes of antihypertensive medications among A, B, C or D;
• Currently taking 3 or more antihypertensive drugs;
• Be unwilling to take antihypertensive drugs, or assumed poor adherence to treatment;

Other illness

• Physician-diagnosed or suspected secondary hypertension (e.g. hypertension caused by renal disease, renal artery stenosis, aortic stenosis, primary aldosteronism, pheochromocytoma/paraganglioma, Cushing's syndrome, thyroid dysfunction, intracranial disease, drug- induced, or rare monogenic genetic disease), or the presence of other structural heart diseases, such as aortic insufficiency, hypertrophic cardiomyopathy, or congenital heart disease;
• Currently at the unstable or terminal stage of any disease (e.g. new- onset cardiovascular and cerebrovascular diseases occurred within 3 months, malignant tumors);
• Have communication or cognitive disorders;

Lab values

• Physician-diagnosed CKD, estimated glomerular filtration rate (eGFR) \<60 mL/min/1.73 m2 (if serum creatinine is available), or currently on dialysis treatment;
• Physician-diagnosed hepatic dysfunction, or ALT≥ 2\*ULN;

Other

• Office or ambulatory SBP≥180 mmHg and/or DBP≥110 mmHg before randomization;
• Physician-diagnosed atrial fibrillation;
• The subject is pregnant or breastfeeding, or planning to become pregnant or breastfeeding during the study period;
• The subject is participating in other clinical trials at the moment.

• An electronic data collection system is routinely used at the clinic for hypertension management in PHC sites, and the distance between sites must be \>2km;
• At least one drug of each of the five classes of recommended antihypertensive medications is available at the clinic:
  • A: Angiotensin-converting enzyme inhibitors (ACEI; e.g., captopril or enalapril);
  • A: Angiotensin receptor blockers (ARB; e.g., losartan or valsartan)
  • B: β-blockers (e.g., atenolol, metoprolol, or bisoprolol)
  • C: Calcium antagonists (e.g., nitrendipine, nifedipine, or amlodipine)
  • D: Diuretics (e.g., hydrochlorothiazide, indapamide, or indapamide SR tablets)
• Has an outpatient clinic for hypertension treatment and staff are willing to take part in the study.
• Age ≥35 years and \<80 years
• Local resident of the community/township who attends the PHC clinic for hypertension management, and will not travel for more than 3 months during the study period;
• Established diagnosis of essential hypertension, with uncontrolled BP before randomization (defined as office BP≥140/90mmHg, and 24-hour ambulatory BP≥130/80mmHg);
• Own and be able to use a smartphone daily;
• Be willing to participate in the study and sign the informed consent.