NCT05608525Completed
Upper Limb tDCS in Chronic Stroke Patients (NOURISH)
Effects of Transcranial Direct Current Stimulation on Upper Limb Motor Rehabilitation in Chronic Stroke Patients
Source: ClinicalTrials.gov · Last updated 23 Feb 2026
Brief summary (registry, in English)
This study is a randomized double-blinded trial investigating the effect of Transcranial Direct Current stimulation (tDCS) on upper limb motor function rehabilitation in chronic stroke patients. 51 subjects will be recruited from National University Hospital (NUH) and be randomized to receive one of the followings: * Group 1 will receive 1 mA anodal tDCS stimulation to the ipsilesional M1 of cortical representation of the affected upper limb; * Group 2 to receive 1mA anodal tDCS to the contralesional premotor cortex; * Group 3 to receive sham tDCS stimulation with anode placed over the scalp area corresponding to ipsilesional M1. tDCS will be performed once a day together with standardized occupational therapy (GRASP) for 20 sessions within 30 days. Group 1 and Group 2 will receive tDCS for 20 minutes during each session, while Group 3 only receives the current stimulation for 20 seconds. GRASP will be performed daily together with tDCS, either concurrently with or immediately after tDCS stimulation. The outcome measures will be measured at baseline, after intervention and 1 month after intervention, including: 1. TMS measurement of corticospinal excitability; 2. functional MRI scan; 3. High density EEG (HD-EEG) evaluation; 4. Clinical measures on upper limb motor function; 5. Cognitive tests.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 1 Nov 2022
- Start date
- 16 Feb 2023
- Primary completion date
- 31 Jul 2025
- Lead sponsor
- National University Hospital, Singapore
- Diseases
- Stroke
- NCT number
- NCT05608525
What you commit to
- Study type: Interventional
- Participants enrolled: 11
- From 16 Feb 2023 to the primary completion date, 31 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any metal implants inside the body that are contraindications of MRI scan;
Other illness
- cardiac pacemakers;
- History of epilepsy;
- Sensorimotor disturbance due to other causes other than stroke;
- Uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina;
- Major depression and a history of psychotic disorders;
- Terminal diagnosis with life expectancy \<=1 year. Any metal implants inside the body that are contraindications of MRI scan;
- 3\. cardiac pacemakers; 4. History of epilepsy; 5. Sensorimotor disturbance due to other causes other than stroke; 6. Claustrophobia; 7. Uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina; 8. Major depression and a history of psychotic disorders; 9. Terminal diagnosis with life expectancy \<=1 year.
Other
- Pregnancy;
- Claustrophobia;
Who the study is looking for
- Age 21-80 years old;
- First ever stroke, 6 months to 2 years after stroke onset;
- ARAT≤42
Age in the registry: 21 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National University Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.