NCT05609578Active, not recruitingPhase 2
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 1 Nov 2022
- Start date
- 22 Nov 2022
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- Mirati Therapeutics Inc.
- Diseases
- Lung cancer
- NCT number
- NCT05609578
- EU CT number
- 2023-503714-77-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 90
- From 22 Nov 2022 to the primary completion date, 30 Sept 2026
- 91 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- All Cohorts: Any prior therapy targeting KRASG12C mutation in any setting
- Cohorts A \& E: Prior systemic therapy for locally advanced or metastatic NSCLC, including chemotherapy, immune checkpoint inhibitor therapy or chemoimmunotherapy (note: prior systemic therapy or chemoradiation given in the adjuvant or neoadjuvant setting are allowed if last dose of prior systemic treatment was \>1 year prior to first dose of study treatment)
- Cohort C: received maintenance therapy (e.g, pembrolizumab and/or pemetrexed following completion of 4-6 cycles of a platinum-based regimen administered in the first-line setting
- Radiation to the lung \> 30 Gy within 6 months prior to first dose of study treatment
Other
- Active brain metastases
Criteria the registry did not label
- Cohort A\* (closed): Has an untreated and unresectable or metastatic NSCLC with histologically confirmed (squamous or nonsquamous) KRASG12C mutation and histologically confirmed PD-L1 TPS ≥1%.
- Cohort C: Has an untreated and unresectable or metastatic NSCLC with histologically confirmed (non-squamous only) KRASG12C mutation and histologically confirmed PD-L1 TPS \< 50% AND previously completed 4 cycles of standard-of-care platinum based induction chemotherapy with pembrolizumab AND experienced stable disease, partial response, or complete response per investigator's assessment after 4 cycles OR if patients received \<4 cycles of a platinum-based induction, was stopped early due to intolerable toxicity
- Cohort E: Has an untreated and unresectable or metastatic NSCLC with histologically confirmed (non-squamous only) KRASG12C mutation and histologically confirmed PD-L1 TPS \< 50%
- Presence of measurable disease per RECIST v1.1
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (91)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Complexo Hospitalario Universitario A Coruña Coordinator of this site? Confirm its status | A Coruña | Spain | Completed |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital General Universitario Gregorio Marañón Coordinator of this site? Confirm its status | Madrid | Spain | Completed |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Completed |
| University Hospital Son Espases Coordinator of this site? Confirm its status | Palma | Spain | Completed |
| Son Llatzer Hospital Coordinator of this site? Confirm its status | Palma De Mallorca | Spain | Completed |
| Hospital Universitario Virgen De La Macarena Coordinator of this site? Confirm its status | Sevilla | Spain | Completed |
| Hospital Clinico Universitario Lozano Blesa Coordinator of this site? Confirm its status | Zaragoza | Spain | Completed |
| Institut de Cancerologie de L'Ouest Coordinator of this site? Confirm its status | Angers | France | Completed |
| Centre Francois Baclesse Coordinator of this site? Confirm its status | Caen Cedex 5 | France | Completed |
| Centre Hospitalier Intercommunal Créteil Coordinator of this site? Confirm its status | Créteil | France | Completed |
| Centr Georges Francois Leclerc Coordinator of this site? Confirm its status | Dijon | France | Completed |
| Centre Hospitalier Universitaire Grenoble Alpes Coordinator of this site? Confirm its status | Grenoble Cedex 9 | France | Completed |
| Institut Paoli-Calmettes Coordinator of this site? Confirm its status | Marseille | France | Completed |
| Hopital Tenon Coordinator of this site? Confirm its status | Paris Cedex 20 | France | Completed |
| Hospital Foch Coordinator of this site? Confirm its status | Suresnes | France | Completed |
| Centre Hospitalier Universitaire de Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Completed |
| Institut Gustave Roussy Coordinator of this site? Confirm its status | Villejuif | France | Completed |
| University General Hospital of Heraklion Coordinator of this site? Confirm its status | Heraklion | Greece | Completed |
| General University Hospital of Larissa Coordinator of this site? Confirm its status | Larissa | Greece | Completed |
| Metropolitan Hospital Coordinator of this site? Confirm its status | Pireas | Greece | Completed |
| Orszagos Onkologiai Intezet Coordinator of this site? Confirm its status | Budapest XII | Hungary | Completed |
| AORN San Giuseppe Moscati Avellino Coordinator of this site? Confirm its status | Avellino | Italy | Completed |
| Azienda Unita Sanitaria Locale Della Romagna Coordinator of this site? Confirm its status | Faenza | Italy | Completed |
| Careggi University Hospital Coordinator of this site? Confirm its status | Florence | Italy | Completed |
| Azienda Unita Sanitaria Locale Della Romagna Coordinator of this site? Confirm its status | Lugo | Italy | Completed |
| Azienda Ospedaliero-Universitaria San Luigi Gonzaga Coordinator of this site? Confirm its status | Orbassano | Italy | Completed |
| Azienda Unità Sanitaria Locale della Romagna Coordinator of this site? Confirm its status | Ravenna | Italy | Completed |
| I.F.O. Istituti Fisioterapici Ospitalieri Coordinator of this site? Confirm its status | Rome | Italy | Completed |
| Instytut MSF Sp. z o.o. Coordinator of this site? Confirm its status | Lodz | Poland | Completed |
| Med Polonia Sp z o.o. Coordinator of this site? Confirm its status | Poznan | Poland | Completed |
| Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| Local Institution - 017-814-A Coordinator of this site? Confirm its status | Arlington | United States | Unknown status |
| Local Institution - 017-872-I Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Local Institution - 017-080 Coordinator of this site? Confirm its status | Babylon | United States | Unknown status |
| Local Institution - 017-909 Coordinator of this site? Confirm its status | Bellingham | United States | Unknown status |
| Local Institution - 017-388 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 017-808 Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Local Institution - 017-872-G Coordinator of this site? Confirm its status | Boulder | United States | Unknown status |
| Local Institution - 017-088 Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| Local Institution - 017-972 Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Local Institution - 017-818 Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Local Institution - 017-872-J Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Local Institution - 017-872-D Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Local Institution - 017-879 Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Local Institution - 017-872-F Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Local Institution - 017-872-B Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Local Institution - 017-587 Coordinator of this site? Confirm its status | East Syracuse | United States | Unknown status |
| Local Institution - 017-814 Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Local Institution - 017-820J Coordinator of this site? Confirm its status | Fairway | United States | Unknown status |
| Local Institution - 017-936 Coordinator of this site? Confirm its status | Fountain Valley | United States | Unknown status |
| Local Institution - 017-936C Coordinator of this site? Confirm its status | Fountain Valley | United States | Unknown status |
| Local Institution - 017-851 Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Local Institution - 017-814-B Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Local Institution - 017-829 Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Local Institution - 017-820C Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Local Institution - 017-820B Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Local Institution - 017-820E Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Local Institution - 017-820A Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Local Institution - 017-820H Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Local Institution - 017-820F Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Local Institution - 017-898 Coordinator of this site? Confirm its status | Lakeland | United States | Unknown status |
| Local Institution - 017-872-A Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Local Institution - 017-820D Coordinator of this site? Confirm its status | Lee's Summit | United States | Unknown status |
| Local Institution - 017-872-C Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| Local Institution - 017-872 Coordinator of this site? Confirm its status | Lone Tree | United States | Unknown status |
| Local Institution - 017-878 Coordinator of this site? Confirm its status | Longview | United States | Unknown status |
| Local Institution - 017-838B Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Local Institution - 017-838C Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Local Institution - 017-087 Coordinator of this site? Confirm its status | New Hyde Park | United States | Unknown status |
| Local Institution - 017-085 Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Local Institution - 017-820G Coordinator of this site? Confirm its status | North Kansas City | United States | Unknown status |
| Local Institution - 017-811 Coordinator of this site? Confirm its status | Novi | United States | Unknown status |
| Local Institution - 017-820I Coordinator of this site? Confirm its status | Overland Park | United States | Unknown status |
| Local Institution - 017-878-B Coordinator of this site? Confirm its status | Palestine | United States | Unknown status |
| Local Institution - 017-878-C Coordinator of this site? Confirm its status | Paris | United States | Unknown status |
| Local Institution - 017-082 Coordinator of this site? Confirm its status | Patchogue | United States | Unknown status |
| Local Institution - 017-086 Coordinator of this site? Confirm its status | Port Jefferson | United States | Unknown status |
| Local Institution - 017-535 Coordinator of this site? Confirm its status | Port Jefferson Station | United States | Unknown status |
| Local Institution - 017-081 Coordinator of this site? Confirm its status | Port Jefferson Station | United States | Unknown status |
| Local Institution - 017-872-E Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| Local Institution - 017-814-C Coordinator of this site? Confirm its status | Reston | United States | Unknown status |
| Local Institution - 017-084 Coordinator of this site? Confirm its status | Riverhead | United States | Unknown status |
| Local Institution - 017-830 Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Local Institution - 017-838A Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Local Institution - 017-838 Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Local Institution - 017-540 Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Local Institution - 017-083 Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Local Institution - 017-872-H Coordinator of this site? Confirm its status | Thornton | United States | Unknown status |
| Local Institution - 017-878-A Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| Local Institution - 017-820 Coordinator of this site? Confirm its status | Westwood | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.