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NCT05609578Active, not recruitingPhase 2

Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation

Source: ClinicalTrials.gov · Last updated 23 Jun 2026

Brief summary (registry, in English)

Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation

Status (registry)
Active, not recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
90 (estimated)
First submitted
1 Nov 2022
Start date
22 Nov 2022
Primary completion date
30 Sept 2026
Lead sponsor
Mirati Therapeutics Inc.
Diseases
Lung cancer
NCT number
NCT05609578
EU CT number
2023-503714-77-00

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 90
  • From 22 Nov 2022 to the primary completion date, 30 Sept 2026
  • 91 sites in 7 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • All Cohorts: Any prior therapy targeting KRASG12C mutation in any setting
  • Cohorts A \& E: Prior systemic therapy for locally advanced or metastatic NSCLC, including chemotherapy, immune checkpoint inhibitor therapy or chemoimmunotherapy (note: prior systemic therapy or chemoradiation given in the adjuvant or neoadjuvant setting are allowed if last dose of prior systemic treatment was \>1 year prior to first dose of study treatment)
  • Cohort C: received maintenance therapy (e.g, pembrolizumab and/or pemetrexed following completion of 4-6 cycles of a platinum-based regimen administered in the first-line setting
  • Radiation to the lung \> 30 Gy within 6 months prior to first dose of study treatment

Other

  • Active brain metastases

Criteria the registry did not label

  • Cohort A\* (closed): Has an untreated and unresectable or metastatic NSCLC with histologically confirmed (squamous or nonsquamous) KRASG12C mutation and histologically confirmed PD-L1 TPS ≥1%.
  • Cohort C: Has an untreated and unresectable or metastatic NSCLC with histologically confirmed (non-squamous only) KRASG12C mutation and histologically confirmed PD-L1 TPS \< 50% AND previously completed 4 cycles of standard-of-care platinum based induction chemotherapy with pembrolizumab AND experienced stable disease, partial response, or complete response per investigator's assessment after 4 cycles OR if patients received \<4 cycles of a platinum-based induction, was stopped early due to intolerable toxicity
  • Cohort E: Has an untreated and unresectable or metastatic NSCLC with histologically confirmed (non-squamous only) KRASG12C mutation and histologically confirmed PD-L1 TPS \< 50%
  • Presence of measurable disease per RECIST v1.1

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (91)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Complexo Hospitalario Universitario A Coruña
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A CoruñaSpainCompleted
Hospital Universitario La Paz
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MadridSpainCompleted
Hospital General Universitario Gregorio Marañón
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MadridSpainCompleted
Hospital Universitario Puerta de Hierro de Majadahonda
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MajadahondaSpainCompleted
University Hospital Son Espases
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PalmaSpainCompleted
Son Llatzer Hospital
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Palma De MallorcaSpainCompleted
Hospital Universitario Virgen De La Macarena
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SevillaSpainCompleted
Hospital Clinico Universitario Lozano Blesa
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ZaragozaSpainCompleted
Institut de Cancerologie de L'Ouest
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AngersFranceCompleted
Centre Francois Baclesse
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Caen Cedex 5FranceCompleted
Centre Hospitalier Intercommunal Créteil
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CréteilFranceCompleted
Centr Georges Francois Leclerc
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DijonFranceCompleted
Centre Hospitalier Universitaire Grenoble Alpes
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Grenoble Cedex 9FranceCompleted
Institut Paoli-Calmettes
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MarseilleFranceCompleted
Hopital Tenon
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Paris Cedex 20FranceCompleted
Hospital Foch
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SuresnesFranceCompleted
Centre Hospitalier Universitaire de Toulouse
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ToulouseFranceCompleted
Institut Gustave Roussy
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VillejuifFranceCompleted
University General Hospital of Heraklion
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HeraklionGreeceCompleted
General University Hospital of Larissa
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LarissaGreeceCompleted
Metropolitan Hospital
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PireasGreeceCompleted
Orszagos Onkologiai Intezet
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Budapest XIIHungaryCompleted
AORN San Giuseppe Moscati Avellino
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AvellinoItalyCompleted
Azienda Unita Sanitaria Locale Della Romagna
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FaenzaItalyCompleted
Careggi University Hospital
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FlorenceItalyCompleted
Azienda Unita Sanitaria Locale Della Romagna
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LugoItalyCompleted
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
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OrbassanoItalyCompleted
Azienda Unità Sanitaria Locale della Romagna
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RavennaItalyCompleted
I.F.O. Istituti Fisioterapici Ospitalieri
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RomeItalyCompleted
Instytut MSF Sp. z o.o.
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LodzPolandCompleted
Med Polonia Sp z o.o.
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PoznanPolandCompleted
Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy
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WarsawPolandCompleted
Local Institution - 017-814-A
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ArlingtonUnited StatesUnknown status
Local Institution - 017-872-I
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AuroraUnited StatesUnknown status
Local Institution - 017-080
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BabylonUnited StatesUnknown status
Local Institution - 017-909
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BellinghamUnited StatesUnknown status
Local Institution - 017-388
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BostonUnited StatesUnknown status
Local Institution - 017-808
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BostonUnited StatesUnknown status
Local Institution - 017-872-G
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BoulderUnited StatesUnknown status
Local Institution - 017-088
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BrooklynUnited StatesUnknown status
Local Institution - 017-972
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ChicagoUnited StatesUnknown status
Local Institution - 017-818
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ClevelandUnited StatesUnknown status
Local Institution - 017-872-J
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Colorado SpringsUnited StatesUnknown status
Local Institution - 017-872-D
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Colorado SpringsUnited StatesUnknown status
Local Institution - 017-879
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DallasUnited StatesUnknown status
Local Institution - 017-872-F
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DenverUnited StatesUnknown status
Local Institution - 017-872-B
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DenverUnited StatesUnknown status
Local Institution - 017-587
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East SyracuseUnited StatesUnknown status
Local Institution - 017-814
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FairfaxUnited StatesUnknown status
Local Institution - 017-820J
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FairwayUnited StatesUnknown status
Local Institution - 017-936
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Fountain ValleyUnited StatesUnknown status
Local Institution - 017-936C
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Fountain ValleyUnited StatesUnknown status
Local Institution - 017-851
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FullertonUnited StatesUnknown status
Local Institution - 017-814-B
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GainesvilleUnited StatesUnknown status
Local Institution - 017-829
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JacksonvilleUnited StatesUnknown status
Local Institution - 017-820C
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Kansas CityUnited StatesUnknown status
Local Institution - 017-820B
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Kansas CityUnited StatesUnknown status
Local Institution - 017-820E
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Kansas CityUnited StatesUnknown status
Local Institution - 017-820A
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Kansas CityUnited StatesUnknown status
Local Institution - 017-820H
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Kansas CityUnited StatesUnknown status
Local Institution - 017-820F
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Kansas CityUnited StatesUnknown status
Local Institution - 017-898
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LakelandUnited StatesUnknown status
Local Institution - 017-872-A
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LakewoodUnited StatesUnknown status
Local Institution - 017-820D
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Lee's SummitUnited StatesUnknown status
Local Institution - 017-872-C
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LittletonUnited StatesUnknown status
Local Institution - 017-872
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Lone TreeUnited StatesUnknown status
Local Institution - 017-878
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LongviewUnited StatesUnknown status
Local Institution - 017-838B
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MinneapolisUnited StatesUnknown status
Local Institution - 017-838C
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MinneapolisUnited StatesUnknown status
Local Institution - 017-087
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New Hyde ParkUnited StatesUnknown status
Local Institution - 017-085
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New YorkUnited StatesUnknown status
Local Institution - 017-820G
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North Kansas CityUnited StatesUnknown status
Local Institution - 017-811
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NoviUnited StatesUnknown status
Local Institution - 017-820I
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Overland ParkUnited StatesUnknown status
Local Institution - 017-878-B
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PalestineUnited StatesUnknown status
Local Institution - 017-878-C
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ParisUnited StatesUnknown status
Local Institution - 017-082
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PatchogueUnited StatesUnknown status
Local Institution - 017-086
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Port JeffersonUnited StatesUnknown status
Local Institution - 017-535
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Port Jefferson StationUnited StatesUnknown status
Local Institution - 017-081
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Port Jefferson StationUnited StatesUnknown status
Local Institution - 017-872-E
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PuebloUnited StatesUnknown status
Local Institution - 017-814-C
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RestonUnited StatesUnknown status
Local Institution - 017-084
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RiverheadUnited StatesUnknown status
Local Institution - 017-830
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RochesterUnited StatesUnknown status
Local Institution - 017-838A
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Saint Louis ParkUnited StatesUnknown status
Local Institution - 017-838
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Saint Louis ParkUnited StatesUnknown status
Local Institution - 017-540
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San FranciscoUnited StatesUnknown status
Local Institution - 017-083
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The BronxUnited StatesUnknown status
Local Institution - 017-872-H
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ThorntonUnited StatesUnknown status
Local Institution - 017-878-A
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TylerUnited StatesUnknown status
Local Institution - 017-820
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WestwoodUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.