NCT05611931Active, not recruitingPhase 3
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
A Phase 3, Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial of Selinexor in Maintenance Therapy After Systemic Therapy for Patients With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 \[RECIST v 1.1\]) after completing at least 12 weeks of platinum-based therapy. A total of 276 participants will be enrolled in the study and randomized in a 1:1 ratio to maintenance therapy with either selinexor or placebo.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 257 (actual)
- First submitted
- 3 Nov 2022
- Start date
- 18 Apr 2023
- Primary completion date
- 22 May 2026
- Lead sponsor
- Karyopharm Therapeutics Inc
- Diseases
- Endometrial cancer
- NCT number
- NCT05611931
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 257
- From 18 Apr 2023 to the primary completion date, 22 May 2026
- 185 sites in 17 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Palliative radiotherapy administered within 14 days of intended C1D1
- Any gastrointestinal dysfunction that could interfere with the absorption of oral study therapy
- Previous treatment with an XPO1 inhibitor
- Known dMMR/MSI-H EC tumors that are medically eligible to receive an immune checkpoint inhibitor
Other illness
- Serious psychiatric or medical conditions that could interfere with study participation or would make study involvement unreasonably hazardous
- Stable disease or disease progression after platinum-based chemotherapy
Other
- Uterine sarcomas, clear cell or small cell carcinoma with neuroendocrine differentiation
- Pregnancy, breastfeeding, or other legal/ethical restrictions to trial participation
Who the study is looking for
- Adults (Aged ≥ 18 years)
- Histologically confirmed endometrial cancer (endometrioid, serous, undifferentiated, or carcinosarcoma sub-types) that is TP53 wild type by central NGS
- Must have completed at least 12 weeks of platinum-based chemotherapy (with or without immune checkpoint inhibitors), with a confirmed partial or complete response according to RECIST v1.1
- Must be able to initiate C1D1 within 3-8 weeks after last platinum dose
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Adequate bone marrow function and organ function
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (185)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Border Medical Oncology & Haematology Coordinator of this site? Confirm its status | Albury | Australia | Unknown status |
| Box Hill Hospital - Eastern Health (Oncology) Coordinator of this site? Confirm its status | Box Hill | Australia | Unknown status |
| Macarthur Cancer Therapy Centre Coordinator of this site? Confirm its status | Campbelltown | Australia | Unknown status |
| Chris O'Brien Lifehouse Coordinator of this site? Confirm its status | Camperdown | Australia | Unknown status |
| Monash Health Coordinator of this site? Confirm its status | Clayton | Australia | Unknown status |
| Frankston Hospital Coordinator of this site? Confirm its status | Frankston | Australia | Unknown status |
| Central Coast LHD - Gosford & Wyong Hospitals Coordinator of this site? Confirm its status | Gosford | Australia | Unknown status |
| Royal Hobart Hospital Coordinator of this site? Confirm its status | Hobart | Australia | Unknown status |
| Cabrini Health Coordinator of this site? Confirm its status | Malvern | Australia | Unknown status |
| Newcastle Private Hospital Coordinator of this site? Confirm its status | New Lambton Heights | Australia | Unknown status |
| Royal North Shore Hospital Coordinator of this site? Confirm its status | Saint Leonards | Australia | Unknown status |
| ICON Cancer Centre - Southport Coordinator of this site? Confirm its status | Southport | Australia | Unknown status |
| The Royal Adelaide Hospital Coordinator of this site? Confirm its status | Southport | Australia | Unknown status |
| Toowoomba Hospital Coordinator of this site? Confirm its status | Toowoomba | Australia | Unknown status |
| Westmead Hospital Coordinator of this site? Confirm its status | Wentworthville | Australia | Unknown status |
| Cliniques Universitaires St-Luc Coordinator of this site? Confirm its status | Brussels | Belgium | Unknown status |
| AZ Sint-Lucas Coordinator of this site? Confirm its status | Ghent | Belgium | Unknown status |
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Unknown status |
| CHU Ambroise Paré Coordinator of this site? Confirm its status | Mons | Belgium | Unknown status |
| CHU UCL Namur / Site Sainte Elisabeth Coordinator of this site? Confirm its status | Namur | Belgium | Unknown status |
| Cross Cancer Institute Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| McGill University Health Centre (MUHC) Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Hospital Maisonneuve-Rosemont Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Centre Hospitalier de l'Université de Montréal Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Sunnybrook Research Institute Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Princess Margaret Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| University Hospital Brno Coordinator of this site? Confirm its status | Brno | Czechia | Unknown status |
| University Hospital Ostrava Coordinator of this site? Confirm its status | Ostrava | Czechia | Unknown status |
| UH Královské Vinohrady Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| General University Hospital in Prague Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Hospital Na Bulovce Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Charite Berlin Universitatsmedizin Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Universitätsklinikum Hamburg-Eppendorf Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| Universitatsklinikum Schleswig-Holstein Coordinator of this site? Confirm its status | Kiel | Germany | Unknown status |
| University Hospital Dresden Coordinator of this site? Confirm its status | Kiel | Germany | Unknown status |
| Helios Klinikum Krefeld Coordinator of this site? Confirm its status | Krefeld | Germany | Unknown status |
| Universitätsklinik Leipzig Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| Universitätsfrauenklinik Mainz Coordinator of this site? Confirm its status | Mainz | Germany | Unknown status |
| Universitätsmedizin Mannheim Coordinator of this site? Confirm its status | Mannheim | Germany | Unknown status |
| Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe GroBhadern Coordinator of this site? Confirm its status | Munich | Germany | Unknown status |
| Klinikum Südstadt Rostock Coordinator of this site? Confirm its status | Rostock | Germany | Unknown status |
| Universitätsfrauenklinik Ulm Coordinator of this site? Confirm its status | Ulm | Germany | Unknown status |
| ICO Badalona Coordinator of this site? Confirm its status | Badalona | Spain | Unknown status |
| Institut Català d'Oncologia Hospitalet Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Unknown status |
| Hospital Universitario Donostia Coordinator of this site? Confirm its status | Donostia / San Sebastian | Spain | Unknown status |
| Institut Català d'Oncologia de Girona. Coordinator of this site? Confirm its status | Girona | Spain | Unknown status |
| Hospital Universitario Virgen de las Nieves Coordinator of this site? Confirm its status | Granada | Spain | Unknown status |
| Hospital Universitario Ramón y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| H. 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| MD Anderson Cancer Center Madrid Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Universitario Clínico San Carlos Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Universitatrio Virgen de la Victoria Coordinator of this site? Confirm its status | Málaga | Spain | Unknown status |
| Virgen de la Arrixaca University Clinical Hospital Coordinator of this site? Confirm its status | Murcia | Spain | Unknown status |
| Hospital Universitario Virgen del Rocio Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| Hospital LaFe Uacenlia Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
| Instituto Valenciano de Oncologia Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
| Hospital Clinico Universitario de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
| Hospital Miguel Servet Coordinator of this site? Confirm its status | Zaragoza | Spain | Unknown status |
| Hospital Clinico Universitario Lozano Blesa Coordinator of this site? Confirm its status | Zaragoza | Spain | Unknown status |
| High Technology Hospital Medcenter Coordinator of this site? Confirm its status | Batumi | Georgia | Unknown status |
| LTD "New Hospitals" Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Tbilisi Cancer Center Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| JSC K. Eristavi National Center of Experimental and Clinical Surgery Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Todua Clinic Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| LTD Innova Medical Center Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Caucasus Medical Centre Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| Multiprofile Clinic Consilium Medulla Coordinator of this site? Confirm its status | Tbilisi | Georgia | Unknown status |
| HYGEIA Hospital Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Alexandra Hospital Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Euromedica General Clinic Coordinator of this site? Confirm its status | Thessaloniki | Greece | Unknown status |
| Unit of Gynecol.Oncol., Dept.Obstet.Gynecol., Clinical Center, University of Debrecen Coordinator of this site? Confirm its status | Debrecen | Hungary | Unknown status |
| Petz Aladár University Teaching Hospital Coordinator of this site? Confirm its status | Győr | Hungary | Unknown status |
| Cork University Hospital Coordinator of this site? Confirm its status | Cork | Ireland | Unknown status |
| St James Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| St Vincent's University Hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| Galway University Coordinator of this site? Confirm its status | Galway | Ireland | Unknown status |
| University Hospital Waterford Coordinator of this site? Confirm its status | Waterford | Ireland | Unknown status |
| Hillel Yaffe Medical Center Coordinator of this site? Confirm its status | Hadera | Israel | Unknown status |
| Wolfson Medical Center Coordinator of this site? Confirm its status | Holon | Israel | Unknown status |
| Hadassah medical Center Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Sheba medical center Coordinator of this site? Confirm its status | Ramat Gan | Israel | Unknown status |
| IRCCS Azienda Ospedaliero-Universitaria di Bologna Coordinator of this site? Confirm its status | Bologna | Italy | Unknown status |
| ASST Spedali Civili di Brescia Coordinator of this site? Confirm its status | Brescia | Italy | Unknown status |
| IRCCS Istituto Romagnolo Per Lo Studio Del Tumori "Dino Amadori" - IRST S.R.L. Coordinator of this site? Confirm its status | Meldola | Italy | Unknown status |
| Humanitas San Pio X Hospital Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| San Raffaele Hospital Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Instituto Europeo di Oncologia Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Istituto Nazionale dei Tumori IRCCS - MILANO S. C. Ginecologia Oncologica Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
| Ospedale San Gerardo - ASST Monza Coordinator of this site? Confirm its status | Monza | Italy | Unknown status |
| "Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" - NAPOLI Struttura Complessa Oncologia Medica Uro-Ginecologica" Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
| Istituto Oncologico Veneto Coordinator of this site? Confirm its status | Padova | Italy | Unknown status |
| Università di Pisa Coordinator of this site? Confirm its status | Pisa | Italy | Unknown status |
| Nuovo Ospedale di Prato Coordinator of this site? Confirm its status | Prato | Italy | Unknown status |
| Fondazione Policlinico Universitario Agostino Gemelli - ROMA Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| Ospedale Ostetrico Ginecologico Sant'Anna Coordinator of this site? Confirm its status | Torino | Italy | Unknown status |
| AO Ordine Mauriziano Coordinator of this site? Confirm its status | Torino | Italy | Unknown status |
| CHA University - Bundang CHA General Hospital Coordinator of this site? Confirm its status | Seongnam-si | South Korea | Unknown status |
| Korea University Anam Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| UH Bratislava Coordinator of this site? Confirm its status | Bratislava | Slovakia | Unknown status |
| St. Elisabeth Cancer Institute Coordinator of this site? Confirm its status | Bratislava | Slovakia | Unknown status |
| National Cancer Institute Coordinator of this site? Confirm its status | Bratislava | Slovakia | Unknown status |
| UH Trenčín Coordinator of this site? Confirm its status | Trenčín | Slovakia | Unknown status |
| Kaohsiung Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Unknown status |
| Taichung Veterans General Hospital Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
| Chi Mei Medical Center Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
| MacKay Memorial Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
| Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Taoyuan City | Taiwan | Unknown status |
| Women's Cancer Care Associates LLC Coordinator of this site? Confirm its status | Albany | United States | Unknown status |
| Illinois Cancer Specialists Coordinator of this site? Confirm its status | Arlington Heights | United States | Unknown status |
| Grady Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Georgia Cancer Center at Augusta University Coordinator of this site? Confirm its status | Augusta | United States | Unknown status |
| USON - Texas Oncology, Austin Central Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Intermountain Health St. Vincent Regional Hospital Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| The University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Tufts Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Atrium Health Levine Cancer Institute Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| University of Virginia Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| MetroHealth Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Zangmeister Cancer Center Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Texas Oncology - Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Parkland Health & Hospital System Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| University of Texas Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| UC DAVIS Coordinator of this site? Confirm its status | Davis | United States | Unknown status |
| Karmanos Cancer Institute Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| City of Hope National Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Duke Cancer Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Northwest Cancer Center Coordinator of this site? Confirm its status | Dyer | United States | Unknown status |
| Oncology Associates of Oregon Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| Northshore University Health System Coordinator of this site? Confirm its status | Evanston | United States | Unknown status |
| Broward Health Medical Center Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Goshen Health Coordinator of this site? Confirm its status | Goshen | United States | Unknown status |
| Houston Methodist Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| St Vincent Hospital Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| University of Iowa Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| City of Hope at Irvine Lennar Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| St. Dominic's Gynecologic Oncology Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Midwest Ventures Group HCA MId America Division Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| University of Tennessee Medical Center Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Alliance Cancer Specialists Coordinator of this site? Confirm its status | Langhorne | United States | Unknown status |
| University of Arkansas for Medical Sciences Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| Cancer and Blood Specialty Clinic Coordinator of this site? Confirm its status | Los Alamitos | United States | Unknown status |
| UCLA Women's Health Clinical Research Unit Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Long Beach Memorial Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of Wisconsin Hospital and Clinics Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| University of Tennessee Health Science Center Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Mount Sinai Comprehensive Cancer Center Coordinator of this site? Confirm its status | Miami Beach | United States | Unknown status |
| NYU Langone Hospital - Long Island Coordinator of this site? Confirm its status | Mineola | United States | Unknown status |
| USON - Minnesota Oncology Hematology Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Northwell Health - Zuckerberg Cancer Center Coordinator of this site? Confirm its status | New Hyde Park | United States | Unknown status |
| LSU Health Sciences Center - New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Perlmutter Cancer Center at NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Lenox Hill Hospital Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Advent Health Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Stanford University Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Honor Health Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Magee - Women's Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Allegheny Health Network - West Penn Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Northwell Health - Queens Cancer Center Coordinator of this site? Confirm its status | Rego Park | United States | Unknown status |
| Center of Hope Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| Texas Oncology - San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| California Pacific Medical Center Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Avera Coordinator of this site? Confirm its status | Sioux Falls | United States | Unknown status |
| ProMedica Flower Hospital Coordinator of this site? Confirm its status | Sylvania | United States | Unknown status |
| Texas Oncology-The Woodlands Coordinator of this site? Confirm its status | The Woodlands | United States | Unknown status |
| Oklahoma Cancer Specialists and Research Institute, LLC Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Texas Oncology, PC, Tyler Coordinator of this site? Confirm its status | Tyler | United States | Unknown status |
| Cukurova University Coordinator of this site? Confirm its status | Adana | Turkey (Türkiye) | Unknown status |
| Adana Baskent Hospital Coordinator of this site? Confirm its status | Adana | Turkey (Türkiye) | Unknown status |
| Hacettepe University Oncology Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Memorial Ankara Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Ankara Baskent Hospital Coordinator of this site? Confirm its status | Çankaya | Turkey (Türkiye) | Unknown status |
| Cerrahpasa University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
| Acibadem Atakent Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.