NCT05612347Recruiting
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 6434 (estimated)
- First submitted
- 4 Nov 2022
- Start date
- 14 Jun 2023
- Primary completion date
- 31 May 2030
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Diseases
- Colorectal cancer
- NCT number
- NCT05612347
What you commit to
- Study type: Interventional
- Planned participants: 6434
- From 14 Jun 2023 to the primary completion date, 31 May 2030
- 24 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Personal history of colorectal cancer
- Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
- Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
- Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
Other
- Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
- Patients unable to provide written informed consent
Who the study is looking for
- English or Spanish speaking
- Personal history of colorectal polyps
- Most recent colonoscopy with ≤2 non-advanced polyps
- Currently due or coming due within 12 months for colonoscopy
- Able to provide written informed consent
Age in the registry: 65 years to 82 years · Sex: All · Does not accept healthy volunteers
Sites (24)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Of Calgary Coordinator of this site? Confirm its status | Calgary | Canada | Recruiting |
| London Health Sciences Centre Research Institute Coordinator of this site? Confirm its status | London | Canada | Recruiting |
| University of British Columbia Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
| University of Manitoba Coordinator of this site? Confirm its status | Winnipeg | Canada | Recruiting |
| University of Michigan Health Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| University of Colorado Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
| University of Alabama Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Active, not recruiting |
| Wake Forest University Health Sciences Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| University of Virginia Health Coordinator of this site? Confirm its status | Charlottesville | United States | Recruiting |
| Northwestern Memorial Hospital Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Henry Ford Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
| Richard L. Roudebush VA Medical Center Coordinator of this site? Confirm its status | Indianapolis | United States | Recruiting |
| Dartmouth Health Coordinator of this site? Confirm its status | Lebanon | United States | Recruiting |
| New York Harbor Health Care System - Dept of Veterans Affairs Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Kaiser Permanente Northwest Coordinator of this site? Confirm its status | Portand | United States | Terminated |
| Oregon Health & Science University, Knight Cancer Institute Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| Jennifer Moreno Department of Veterans Affairs Medical Cneter Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| Intermountain Health Coordinator of this site? Confirm its status | Sandy City | United States | Recruiting |
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| James A. Haley Veterans Hospital Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
| University of Arizona Coordinator of this site? Confirm its status | Tucson | United States | Recruiting |
| Kaiser Permanente Northern California Coordinator of this site? Confirm its status | Walnut Creek | United States | Recruiting |
| MedStar Health Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
Related publications
- Race, ethnicity, and prior colorectal screening test use in CONFIRM colonoscopy vs fecal immunochemical testing trial participants.JNCI Cancer Spectr · 2026 · PMID 42644818
This page is information, not medical advice. Discuss any trial with your doctor.