NCT05613218CompletedPhase 2/3
Oxygen Targets in Acute Heart Failure With Pulmonary Congestion
Restrictive Versus Liberal Oxygenation Targets in Patients With Acute Heart Failure and Pulmonary Congestion - a Randomized Clinical Pilot-trial
Source: ClinicalTrials.gov · Last updated 26 Oct 2026
Brief summary (registry, in English)
REDOX-AHF compared two oxygen saturation targets in adults admitted with acute heart failure and clinical or radiological signs of congestion. Participants were randomly assigned to a restrictive target of 89-91% or a liberal target of 95-97% for 24 hours. An automated oxygen delivery device adjusted oxygen flow while concealing the assigned target from participants and study staff. The main assessment was lung fluid content after 24 hours, measured noninvasively by remote dielectric sensing (ReDS). The trial was conducted at two Danish hospitals. A total of 135 participants were randomized; 134 remained in the modified intention-to-treat population after one participant withdrew consent. The target of 122 participants with complete primary-outcome measurements was reached. Follow-up continued to day 30.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 135 (actual)
- First submitted
- 4 Nov 2022
- Start date
- 1 Feb 2024
- Primary completion date
- 2 Feb 2026
- Lead sponsor
- Copenhagen University Hospital, Hvidovre
- Diseases
- Heart failure
- NCT number
- NCT05613218
What you commit to
- Study type: Interventional · Phase 2/3
- Participants enrolled: 135
- From 1 Feb 2024 to the primary completion date, 2 Feb 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Suspected infection or sepsis
- Known severe pulmonary disease
Other
- More than 4 hours from hospital admission to randomization
- Systolic blood pressure \<90 mmHg
Who the study is looking for
- Age ≥ 18 years
- Acute (within minutes to days) onset or worsening of subjective dyspnea
- Oxygen saturation \<92% (on arterial blood gas) or need of oxygen
- At least one of the following clinical or radiological signs of congestion:
- 1\. Pulmonary rales 2. Chest X-ray or CT with pulmonary congestion 3. Lung ultrasound with multiple B-lines
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Bispebjerg Hospital Coordinator of this site? Confirm its status | Copenhagen | Denmark | Unknown status |
| Amager-Hvidovre Hospital Coordinator of this site? Confirm its status | Hvidovre | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.