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NCT05615610Recruiting

Effects of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke

A Randomized Controlled Clinical Trial of Transcutaneous Electrical Nerve Stimulation on Cognitive Function and Upper Limb Motor Function in People With Chronic Stroke

Source: ClinicalTrials.gov · Last updated 16 Oct 2026

Brief summary (registry, in English)

Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke. Previous study also revealed that 53.4% of people after stroke experienced cognitive impairment. Different cognitive domains might be affected following stroke, such as attention, memory, language, and orientation, and the problems with memory are often prominent. Yet, there is no effective treatment for the post-stroke cognitive impairment. Transcutaneous spinal cord stimulation (tSCS) and transcutaneous vagus nerve stimulation (tVNS) are simple and non-invasive treatment to improve upper limb motor function and cognitive function. However, no existing studies have explored on the effects of tSCS and tVNS on cognitive function in people with stroke. Therefore, the purpose of this study is to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) on improving upper limb function and cognitive function in people with chronic stroke.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
90 (estimated)
First submitted
7 Nov 2022
Start date
1 Nov 2023
Primary completion date
15 Dec 2026
Lead sponsor
The Hong Kong Polytechnic University
Diseases
Stroke
NCT number
NCT05615610

What you commit to

  • Study type: Interventional
  • Planned participants: 90
  • From 1 Nov 2023 to the primary completion date, 15 Dec 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • are taking medication that may affect measured outcomes;
  • are participating in other drug/treatment programs.

Other illness

  • have cardiac pacemaker or cochlear implant;
  • have other neurological diseases;
  • have skin lesions, infection, or inflammation near selected position;

Who the study is looking for

  • aged between 50 and 80;
  • have suffered from a single stroke at least 6 months;
  • had volitional control of the non-paretic arm and at least minimal antigravity movement in the paretic shoulder;

Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
The Hong Kong Polytechnic University
Coordinator of this site? Confirm its status		Hong KongHong Kong SAR ChinaRecruiting

Related publications

This page is information, not medical advice. Discuss any trial with your doctor.