NCT05617898Recruiting
Determining the Role of Social Reward Learning in Social Anhedonia
Determining the Role of Social Reward Learning in Social Anhedonia in First-Episode Psychosis Using Motivational Interviewing in a Perturbation-Based Neuroimaging Approach
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels. Individuals who recently experienced their first-episode psychosis will be recruited. Participants will be randomized 1:1 to motivational interviewing or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. With this design feature, we will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 152 (estimated)
- First submitted
- 31 Oct 2022
- Start date
- 14 Jun 2023
- Primary completion date
- Nov 2027
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Schizophrenia
- NCT number
- NCT05617898
What you commit to
- Study type: Interventional
- Planned participants: 152
- From 14 Jun 2023 to the primary completion date, Nov 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- No medication change 3 weeks prior to enrollment
Other illness
- No evidence of moderate or severe alcohol or substance use disorder in the past 3 months
- No clinically significant disease based on medical history (e.g., epilepsy) or significant head injury
Other
- No evidence that substance use makes the diagnosis ambiguous (rule out substance-induced psychosis)
- For females: no current pregnancy
- No sedatives or anxiolytics on the day of assessment
Who the study is looking for
- Age 18-35 years
- A first episode of a psychotic illness that began within the past three years
- Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
- Taking 2nd generation antipsychotic medications
- Estimated premorbid IQ not less than 70 as assessed with the Wechsler Test of Adult Reading
- Appropriate for scanning (i.e., no pacemaker or metal implants) and expressed willingness to participate in scanning
- Sufficient fluency in English to comprehend testing procedures
- Corrected vision of at least 20/30
Age in the registry: 18 years to 35 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
| University of California, Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.