NCT05625724RecruitingPhase 3
Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology
Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes in Nulliparous Women After Assisted Reproductive Technology. APPART
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
This study seeks to validate the hypothesis that nulliparous pregnant women after Assisted Reproductive Technology (ART) are at high risk of preeclampsia and perinatal complications and represent a subgroup for which aspirin prophylaxis during pregnancy may be effective in the prevention of preterm preeclampsia and other perinatal adverse outcomes.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 1164 (estimated)
- First submitted
- 14 Nov 2022
- Start date
- 2 Aug 2023
- Primary completion date
- Aug 2028
- Lead sponsor
- University Hospital, Toulouse
- NCT number
- NCT05625724
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 1164
- From 2 Aug 2023 to the primary completion date, Aug 2028
- 21 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Regular treatment with aspirin (including antiphospholipid syndrome)
Other illness
- Aspirin contraindications (allergy, von Willebrand disease, peptic ulceration, hemophilia)
Other
- Major fetal abnormality
- Women protected by law.
- Women included in another interventional study.
Who the study is looking for
- Nulliparous women aged 18 years or more
- Pregnancy following ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), oocyte donation or intrauterine insemination with sperm donor
- Singleton pregnancy
- Evolutive pregnancy between 9 and 14 weeks of gestation
- Women affiliated to a French Social Security Insurance or equivalent social protection
- Written informed consent
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (21)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Angers Coordinator of this site? Confirm its status | Angers | France | Recruiting |
| CHU Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Recruiting |
| CHU Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Recruiting |
| Chu Dijon Bourgogne Coordinator of this site? Confirm its status | Dijon | France | Recruiting |
| CHU Lille Coordinator of this site? Confirm its status | Lille | France | Recruiting |
| HCL - Groupement Hospitalier Est, Hôpital Femme Mère Enfant Coordinator of this site? Confirm its status | Lyon | France | Recruiting |
| AP-HM Hôpital Nord Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
| AP-HM Hôpital de la Conception Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
| CHU Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Recruiting |
| CHRU Nancy Coordinator of this site? Confirm its status | Nancy | France | Recruiting |
| CHU Nantes Coordinator of this site? Confirm its status | Nantes | France | Recruiting |
| CHU Nîmes Coordinator of this site? Confirm its status | Nîmes | France | Recruiting |
| Hôpital Armand-Trousseau Coordinator of this site? Confirm its status | Paris | France | Not yet recruiting |
| Groupe hospitalier St Joseph Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| Hôpital Cochin Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| CHI Poissy-Saint-Germain en Laye Coordinator of this site? Confirm its status | Poissy | France | Recruiting |
| CHU Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Not yet recruiting |
| CHU Rennes Coordinator of this site? Confirm its status | Rennes | France | Recruiting |
| CHU Saint Etienne Hôpital Nord Coordinator of this site? Confirm its status | Saint-Etienne | France | Recruiting |
| CHU Strasbourg Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
| CHU Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.