NCT05626907Completed
Does What You Eat Affect Your Brain
Assessing the Effect of Diet on Hypothalamic Gliosis in Humans
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to use magnetic resonance imaging (MRI) to evaluate the human hypothalamus for signs of inflammation in response to specific diets. This research may lead to a better understanding of how poor nutritional quality may lead to obesity through effects on regions of the brain known to regulate body weight.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 36 (actual)
- First submitted
- 23 Sept 2022
- Start date
- 13 Jan 2023
- Primary completion date
- 28 Jan 2025
- Lead sponsor
- University of Washington
- Diseases
- Obesity
- NCT number
- NCT05626907
What you commit to
- Study type: Interventional
- Participants enrolled: 36
- From 13 Jan 2023 to the primary completion date, 28 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of orlistat or other weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics)
Other illness
- History of bariatric surgery or active participation in weight-loss program
- Major medical or neurological disorder (e.g., diabetes, multiple sclerosis)
- Known gallbladder disease or gallstones
- Lifetime eating disorder
Lab values
- Hypertriglyceridemia (\>350 mg/dl)
Other
- Anemia or impaired kidney or liver function
- More than moderate level of physical activity (\>1000 met-min/wk)
- Pregnancy, menopause, or breastfeeding
- MRI contraindication (e.g., implanted metal, claustrophobia)
- Current smoking or heavy alcohol use (≥ 2 drinks per day for females and ≥ 3 drinks per day for males)
- Weight \> 350 pounds (MRI limit)
- Dietary restrictions (e.g., vegan) incompatible with controlled diets
Who the study is looking for
- Age 20-40 years
- Overweight: BMI 25-29.9 kg/m2
- Willing to undergo randomly assigned 14-day diet modification
Age in the registry: 20 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Washington Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.