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NCT05635786Completed

Early Recanalization After Intravenous Thrombolysis With Tenecteplase Versus Alteplase in Distal Vessel Occlusion Strokes

Early Successful Recanalization After Intravenous Thrombolysis With Tenecteplase Versus Alteplase in Distal Vessel Occlusion Strokes

Source: ClinicalTrials.gov · Last updated 13 Mar 2025

Brief summary (registry, in English)

The purpose of this monocentric retrospective study is to compare, in patients with acute distal vessel occlusion stroke, the early rates of successful recanalization in patients treated with Alteplase (ALT) versus Tenecteplase (TNK), based on a retrospective analysis of magnetic resonance imaging (MRI) performed early after IVT.

Status (registry)
Completed
Study type
Observational
Enrollment
319 (actual)
First submitted
23 Nov 2022
Start date
2 Jan 2023
Primary completion date
21 Nov 2024
Lead sponsor
Centre Hospitalier Sud Francilien
Diseases
Stroke
NCT number
NCT05635786

What you commit to

  • Study type: Observational
  • Participants enrolled: 319
  • From 2 Jan 2023 to the primary completion date, 21 Nov 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • \- Patients informed of the study who objected to the collection of their data.

Who the study is looking for

  • Age≥ 18 years.
  • Acute ischemic stroke (visible on DWI, but not visible on FLAIR) on initial MRI associated with distal arterial occlusion as defined below:
    • A distal occlusion of the M2 segment of the middle cerebral artery (MCA)
    • Occlusion (regardless of location) of a non-dominant M2 branch of the MCA
    • Occlusion of the M3 segment of the MCA.
    • Occlusion of the A2 or A3 segment of the anterior cerebral artery (ACA)
    • Occlusion of the P2 or P3 branch of the posterior cerebral artery (PCA).
    • A proximal M2-MCA or proximal P1-PCA occlusion may also be included if not eligible for mechanical thrombectomy, especially if the initial NIHSS score is low (\<5).
    • Distal arterial occlusion is identified by MRI either on the TOF (Time of Flight)-ARM sequence and/or on the presence of a thrombus (Susceptibility Vessel sign, SVS) on the SWAN sequence,
  • IVT by ALT or TNK within 4H30 after onset of symptoms,
  • Early brain MRI performed 1 to 2 hours after IVT (MRI n°2),
  • Good quality MRI (absence of motion artifact interfering with interpretation) with availability of DWI, FLAIR, TOF-MRA and SWAN sequences.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Centre Hospitalier Sud Francilien
Coordinator of this site? Confirm its status		Corbeil-EssonnesFranceUnknown status

Related publications

This page is information, not medical advice. Discuss any trial with your doctor.