NCT05636748Recruiting
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
Ischaemic stroke is usually due to occlusion of a cerebral artery by thrombus. However, it is often difficult to identify the source of thrombus, or to confirm thrombus as a cause of ischaemic stroke. Moreover, it is debated whether thrombosis plays any role in certain types of stroke such as lacunar stroke. In preliminary studies, the investigators have evaluated a novel clinical grade thrombus-specific radiotracer, 18F-GP1, which has a high specificity for the glycoprotein IIb/IIIa receptor on activated platelets. The investigations have demonstrated that 18F-GP1 is highly sensitive to in vivo thrombus formation and demonstrates avid binding to thrombus associated with myocardial infarction, pulmonary embolism and aortic bioprosthesis. This study will use this imaging approach to define the role and origin of thrombus in patients with ischaemic stroke, cryptogenic stroke and lacunar stroke.The investigators will also assess its added clinical value in assessing patients with ischaemic stroke.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 23 Nov 2022
- Start date
- Feb 2023
- Primary completion date
- Dec 2027
- Lead sponsor
- University of Edinburgh
- Diseases
- Stroke
- NCT number
- NCT05636748
What you commit to
- Study type: Observational
- Planned participants: 120
- From Feb 2023 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in the study would result in a delay to carotid endarterectomy surgery
Other illness
- Known allergy to iodinated contrast or radiotracer
- Haemorrhagic stroke
Other
- Inability or unwillingness to provide informed written consent (ie lack capacity)
- Inability to undergo the scanning protocol including ability to transfer onto the scanner
- Women of child- bearing potential in whom pregnancy cannot be excluded
- Contraindication to PET-CT scanning including estimated glomerular filtration rate \<30 mL/min/1.73 m2
- Severe or significant comorbidity precluding ability to complete study procedures.
- Contra-indication to Magnetic Resonance imaging for those patients requiring a MRI Head
Who the study is looking for
- Males and females ≥18 years old
- Diagnoses of acute ischaemic stroke (within 21 days of symptom onset) as per American Heart and Stroke Association guidelines
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinical Research Facility Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Recruiting |
Related publications
- Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.Circulation · 2026 · PMID 42677492
This page is information, not medical advice. Discuss any trial with your doctor.